Elena P. Bulgac, Ph.D.

Elena P. Bulgac, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Office: (585) 275-6710
Fax: (585) 271-2683

Research Bio

Chromosomes instability of human fungal pathogen Candida albicans. Survival due to specific chromosome rearrangements.

Candida albicans is a unicellular budding fungus that forms part of normal gut or genitalia microflora. In immunocompromized humans, however, C. albicans becomes an important opportunistic pathogen that can cause mortality. C. albicans is unique among other fungal pathogens by having an ability to infect divers sites of human body, including skin, nails, mucosal surfaces, as well as any other tissues or inner organs. In the laboratory, this fungus demonstrates an impressive ability to flourish under extreme pH and temperatures, as well as in other extreme environments. C. albicans possesses an acute ability to counter act the environmental stresses and to mount adequate phenotypic responses.

Recent Journal Articles

Showing the 5 most recent journal articles. 41 available »

2016 Dec
Suwunnakorn S, Wakabayashi H, Rustchenko E. "Chromosome 5 of Human Pathogen Candida albicans Carries Multiple Genes for Negative Control of Caspofungin and Anidulafungin Susceptibility." Antimicrobial agents and chemotherapy. 2016 Dec; 60(12):7457-7467. Epub 2016 Nov 21.
Xiao J, Moon Y, Li L, Rustchenko E, Wakabayashi H, Zhao X, Feng C, Gill SR, McLaren S, Malmstrom H, Ren Y, Quivey R, Koo H, Kopycka-Kedzierawski DT. "Candida albicans Carriage in Children with Severe Early Childhood Caries (S-ECC) and Maternal Relatedness." PloS one. 2016 11(10):e0164242. Epub 2016 Oct 14.
2014 Aug
Kravets A, Yang F, Bethlendy G, Sherman F, Rustchenko E. "Adaptation of Candida albicans to growth on sorbose via monosomy of chromosome 5 accompanied by duplication of another chromosome carrying a gene responsible for sorbose utilization." FEMS yeast research. 2014 Aug; 14(5):708-13. Epub 2014 May 13.
2013 Oct
Yang F, Kravets A, Bethlendy G, Welle S, Rustchenko E. "Chromosome 5 monosomy of Candida albicans controls susceptibility to various toxic agents, including major antifungals." Antimicrobial agents and chemotherapy. 2013 Oct; 57(10):5026-36. Epub 2013 Jul 29.
2012 Feb
Ahmad A, Kravets A, Rustchenko E. "Transcriptional regulatory circuitries in the human pathogen Candida albicans involving sense--antisense interactions." Genetics. 2012 Feb; 190(2):537-47. Epub 2011 Nov 30.

Current Appointments

Research Associate Professor - Department of Biochemistry and Biophysics (SMD) - Primary


PhD | Genetics | USSR - Non-Medical School1974
MS | Genetics | USSR - Non-Medical School1971