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Elena P. Bulgac, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-6710

Fax: (585) 271-2683

Research Labs

Biography

Research

Chromosomes instability of human fungal pathogen Candida albicans. Survival due to specific chromosome rearrangements.

Candida albicans is a unicellular budding fungus that forms part of normal gut or genitalia microflora. In immunocompromized humans, however, C. albicans becomes an important opportunistic pathogen that can cause mortality. C. albicans is unique among other fungal pathogens by having an ability to infect divers sites of human body, including skin, nails, mucosal surfaces, as well as any other tissues or inner organs. In the laboratory, this fungus demonstrates an impressive ability to flourish under extreme pH and temperatures, as well as in other extreme environments. C. albicans possesses an acute ability to counter act the environmental stresses and to mount adequate phenotypic responses.

Credentials

Education

1971
MS | USSR - Non-Medical School
Genetics

1974
PhD | USSR - Non-Medical School
Genetics

Publications

Journal Articles

5/2017
Yang F, Zhang L, Wakabayashi H, Myers J, Jiang Y, Cao Y, Jimenez-Ortigosa C, Perlin DS, Rustchenko E. "Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall Remodeling." Antimicrobial agents and chemotherapy.. 2017 May 0; 61(5)Epub 2017 Apr 24.

12/2016
Suwunnakorn S, Wakabayashi H, Rustchenko E. "Chromosome 5 of Human Pathogen Candida albicans Carries Multiple Genes for Negative Control of Caspofungin and Anidulafungin Susceptibility." Antimicrobial agents and chemotherapy.. 2016 Dec 0; 60(12):7457-7467. Epub 2016 Nov 21.

2016
Xiao J, Moon Y, Li L, Rustchenko E, Wakabayashi H, Zhao X, Feng C, Gill SR, McLaren S, Malmstrom H, Ren Y, Quivey R, Koo H, Kopycka-Kedzierawski DT. "Candida albicans Carriage in Children with Severe Early Childhood Caries (S-ECC) and Maternal Relatedness." PloS one. 2016 11(10):e0164242. Epub 2016 Oct 14.

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