Mark David Noble, Ph.D.

Mark David Noble, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 633
Rochester, NY 14642

Office: (585) 273-1448
Lab: (585) 273-2416
Administrative: (585) 273-1440
Fax: (585) 273-1450

Journal Articles

Showing all 66 journal articles available.

2016 Feb
Campbell A, Bushman J, Munger J, Noble M, Pröschel C, Mayer-Pröschel M. "Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia." Glia. 2016 Feb; 64(2):227-39. Epub 2015 Oct 15.
2015 Nov 15
Campbell A, Krupp B, Bushman J, Noble M, Pröschel C, Mayer-Pröschel M. "A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioral defect and a low incidence of lymphoma but no increased oxidative burden." Human molecular genetics. 2015 Nov 15; 24(22):6331-49. Epub 2015 Aug 26.
2015 Sep
Tanner DC, Campbell A, O'Banion KM, Noble M, Mayer-Pröschel M. "cFLIP is critical for oligodendrocyte protection from inflammation." Cell death and differentiation. 2015 Sep; 22(9):1489-501. Epub 2015 Jan 30.
2015 Feb
Noble M, Mayer-Pröschel M, Li Z, Dong T, Cui W, Pröschel C, Ambeskovic I, Dietrich J, Han R, Miranda Yang Y, Folts C, Stripay J, Chen HY, Stevens BM. "Redox biology in normal cells and cancer: restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment." Free radical biology & medicine. 2015 Feb; 79:300-23. Epub 2014 Dec 04.
2014 May
Stevens BM, Folts CJ, Cui W, Bardin AL, Walter K, Carson-Walter E, Vescovi A, Noble M. "Cool-1-mediated inhibition of c-Cbl modulates multiple critical properties of glioblastomas, including the ability to generate tumors in vivo." Stem cells. 2014 May; 32(5):1124-35.
2014 Apr
Proschel C, Stripay JL, Shih CH, Munger JC, Noble MD. "Delayed transplantation of precursor cell-derived astrocytes provides multiple benefits in a rat model of Parkinsons." EMBO molecular medicine. 2014 Apr; 6(4):504-18. Epub 2014 Jan 29.
2013 Oct 16
Wang J, Bushman J, Wang X, Mayer-Proschel M, Johnson M, Noble M. "Oligodendrocyte/type-2 astrocyte progenitor cells and glial-restricted precursor cells generate different tumor phenotypes in response to the identical oncogenes." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Oct 16; 33(42):16805-17.
2013 Sep 18
Chen HY, Yang YM, Han R, Noble M. "MEK1/2 inhibition suppresses tamoxifen toxicity on CNS glial progenitor cells." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Sep 18; 33(38):15069-74.
2013 May 2
Noble M, Mayer-Pröschel M, Pröschel C. "iOPs: a new tool for studying myelin pathologies?" Cell stem cell. 2013 May 2; 12(5):503-4.
2013 May
Chen HY, Yang YM, Stevens BM, Noble M. "Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells." EMBO molecular medicine. 2013 May; 5(5):723-36. Epub 2013 Apr 22.
2011 Oct
Noble M, Davies JE, Mayer-Pröschel M, Pröschel C, Davies SJ. "Precursor cell biology and the development of astrocyte transplantation therapies: lessons from spinal cord injury." Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2011 Oct; 8(4):677-93.
2011 Jan 7
Noble M, Pröschel C, Mayer-Pröschel M. "Oxidative-reductionist approaches to stem and progenitor cell function." Cell stem cell. 2011 Jan 7; 8(1):1-2.
2011 Jan
Chen R, Hyrien O, Noble M, Mayer-Pröschel M. "A composite likelihood approach to the analysis of longitudinal clonal data on multitype cellular systems under an age-dependent branching process." Biostatistics. 2011 Jan; 12(1):173-91. Epub 2010 Aug 23.
Davies, SJ; Shih, CH; Noble, M; Mayer-Proschel, M; Davies, JE; Proschel, C. "Transplantation of specific human astrocytes promotes functional recovery after spinal cord injury." PLoS ONE. 2011; e17328. Link
Noble M, Mayer-Pröschel M, Davies JE, Davies SJ, Pröschel C. "Cell therapies for the central nervous system: how do we identify the best candidates?" Current opinion in neurology. 2011 24(6):570-6.
2010 Jun
Hyrien O, Chen R, Mayer-Pröschel M, Noble M. "Saddlepoint approximations to the moments of multitype age-dependent branching processes, with applications." Biometrics. 2010 Jun; 66(2):567-77. Epub 2009 Jun 09.
Hyrien O, Dietrich J, Noble M. "Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors." Cancer research. 2010 70(24):10051-9. Epub 2010 Nov 05.
Han R, Yang YM, Dietrich J, Luebke A, Mayer-Pröschel M, Noble M. "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system." Journal of biology. 2008 7(4):12. Epub 2008 Apr 22.
Davies JE, Pröschel C, Zhang N, Noble M, Mayer-Pröschel M, Davies SJ. "Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury." Journal of biology. 2008 7(7):24. Epub 2008 Sep 19.
2007 Feb
Li Z, Dong T, Pröschel C, Noble M. "Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function." PLoS biology. 2007 Feb; 5(2):e35.
2006 Sep 21
Jordan CT, Guzman ML, Noble M. "Cancer stem cells." The New England journal of medicine. 2006 Sep 21; 355(12):1253-61.
2006 Feb
Noble M. "Implications for CNS repair of redox modulation of cell survival, division and differentiation." Current Alzheimer research. 2006 Feb; 3(1):37-47.
Davies JE, Huang C, Proschel C, Noble M, Mayer-Proschel M, Davies SJ. "Astrocytes derived from glial-restricted precursors promote spinal cord repair." Journal of biology. 2006 5(3):7. Epub 2006 Apr 27.
Hyrien O, Ambeskovic I, Mayer-Proschel M, Noble M, Yakovlev A. "Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data." Theoretical biology & medical modelling. 2006 3:21. Epub 2006 May 17.
Dietrich J, Han R, Yang Y, Mayer-Pröschel M, Noble M. "CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo." Journal of biology. 2006 5(7):22.
2005 Mar
Dietrich J, Lacagnina M, Gass D, Richfield E, Mayer-Pröschel M, Noble M, Torres C, Pröschel C. "EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy." Nature medicine. 2005 Mar; 11(3):277-83. Epub 2005 Feb 20.
2005 Mar
Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. "A stochastic model to analyze clonal data on multi-type cell populations." Biometrics. 2005 Mar; 61(1):199-207.
2005 Feb
Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. "Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture." Mathematical biosciences. 2005 Feb; 193(2):255-74. Epub 2005 Jan 22.
Hyrien, O.; Mayer-Pröschel, M.; Noble, M.; Yakovlev, A.Y. "Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture". Math. Biosciences. 2005; 193: 255-274. Link
Noble, M. "Neural precursor cells and toxicant action: Addressing the analysis of low-level toxicant exposure". Role of Glia in Neurotoxicity. 2005; 2nd Edition: 1-28. Link
Noble M, Mayer-Pröschel M, Pröschel C. "Redox regulation of precursor cell function: insights and paradoxes." Antioxidants & redox signaling. 2005 7(11-12):1456-67.
Noble M. "Ethics in the trenches: a multifaceted analysis of the stem cell debate." Stem cell reviews. 2005 1(4):345-76.
2004 Mar
Noble M, Dietrich J. "The complex identity of brain tumors: emerging concerns regarding origin, diversity and plasticity." Trends in neurosciences. 2004 Mar; 27(3):148-54.
2004 Jan 1
Noble M, Pröschel C, Mayer-Pröschel M. "Getting a GR(i)P on oligodendrocyte development." Developmental biology. 2004 Jan 1; 265(1):33-52.
2004 Jan
Noble M. "The possible role of myelin destruction as a precipitating event in Alzheimer's disease." Neurobiology of aging. 2004 Jan; 25(1):25-31.
Noble, M.; Pröschel, C.; Mayer-Pröschel, M. "Getting a GR(i)P on oligodendrocyte development". Devel. Biol. 2004; 265: 33-52. Link
Hill CE, Proschel C, Noble M, Mayer-Proschel M, Gensel JC, Beattie MS, Bresnahan JC. "Acute transplantation of glial-restricted precursor cells into spinal cord contusion injuries: survival, differentiation, and effects on lesion environment and axonal regeneration." Experimental neurology. 2004 190(2):289-310.
2003 Nov
Biran R, Noble MD, Tresco PA. "Directed nerve outgrowth is enhanced by engineered glial substrates." Experimental neurology. 2003 Nov; 184(1):141-52.
2003 Jun
Noble M, Smith J, Power J, Mayer-Pröschel M. "Redox state as a central modulator of precursor cell function." Annals of the New York Academy of Sciences. 2003 Jun; 991:251-71.
Noble M, Arhin A, Gass D, Mayer-Pröschel M. "The cortical ancestry of oligodendrocytes: common principles and novel features." Developmental neuroscience. 2003 25(2-4):217-33.
2002 Oct
Dietrich J, Noble M, Mayer-Proschel M. "Characterization of A2B5+ glial precursor cells from cryopreserved human fetal brain progenitor cells." Glia. 2002 Oct; 40(1):65-77.
2002 May 15
Power J, Mayer-Pröschel M, Smith J, Noble M. "Oligodendrocyte precursor cells from different brain regions express divergent properties consistent with the differing time courses of myelination in these regions." Developmental biology. 2002 May 15; 245(2):362-75.
2002 Feb
Noble M, Dietrich J. "Intersections between neurobiology and oncology: tumor origin, treatment and repair of treatment-associated damage." Trends in neurosciences. 2002 Feb; 25(2):103-7.
2002 Jan 1
Gregori N, Pröschel C, Noble M, Mayer-Pröschel M. "The tripotential glial-restricted precursor (GRP) cell and glial development in the spinal cord: generation of bipotential oligodendrocyte-type-2 astrocyte progenitor cells and dorsal-ventral differences in GRP cell function." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 Jan 1; 22(1):248-56.
Mayer-Pröschel M, Morath D, Noble M. "Are hypothyroidism and iron deficiency precursor cell diseases?" Developmental neuroscience. 2001 23(4-5):277-86.
2000 Nov 7
Noble M. "Can neural stem cells be used to track down and destroy migratory brain tumor cells while also providing a means of repairing tumor-associated damage?" Proceedings of the National Academy of Sciences of the United States of America. 2000 Nov 7; 97(23):12393-5.
2000 Aug 29
Smith J, Ladi E, Mayer-Proschel M, Noble M. "Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell." Proceedings of the National Academy of Sciences of the United States of America. 2000 Aug 29; 97(18):10032-7.
1998 Nov 24
Yakovlev AY, Boucher K, Mayer-Proschel M, Noble M. "Quantitative insight into proliferation and differentiation of oligodendrocyte type 2 astrocyte progenitor cells in vitro." Proceedings of the National Academy of Sciences of the United States of America. 1998 Nov 24; 95(24):14164-7.
1998 Mar 31
Rao MS, Noble M, Mayer-Pröschel M. "A tripotential glial precursor cell is present in the developing spinal cord." Proceedings of the National Academy of Sciences of the United States of America. 1998 Mar 31; 95(7):3996-4001.
1996 Nov 25
Ibarrola N, Mayer-Pröschel M, Rodriguez-Peña A, Noble M. "Evidence for the existence of at least two timing mechanisms that contribute to oligodendrocyte generation in vitro." Developmental biology. 1996 Nov 25; 180(1):1-21.
1996 Jul 12
Frangiskakis JM, Ewart AK, Morris CA, Mervis CB, Bertrand J, Robinson BF, Klein BP, Ensing GJ, Everett LA, Green ED, Pröschel C, Gutowski NJ, Noble M, Atkinson DL, Odelberg SJ, Keating MT. "LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition." Cell. 1996 Jul 12; 86(1):59-69.
1995 Oct 5
Pröschel C, Blouin MJ, Gutowski NJ, Ludwig R, Noble M. "Limk1 is predominantly expressed in neural tissues and phosphorylates serine, threonine and tyrosine residues in vitro." Oncogene. 1995 Oct 5; 11(7):1271-81.
1994 Aug 2
Mayer M, Noble M. "N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro." Proceedings of the National Academy of Sciences of the United States of America. 1994 Aug 2; 91(16):7496-500.
1994 Apr
Bögler O, Noble M. "Measurement of time in oligodendrocyte-type-2 astrocyte (O-2A) progenitors is a cellular process distinct from differentiation or division." Developmental biology. 1994 Apr; 162(2):525-38.
1994 Jan
Mayer M, Bhakoo K, Noble M. "Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro." Development. 1994 Jan; 120(1):143-53.
1993 Sep
Groves AK, Entwistle A, Jat PS, Noble M. "The characterization of astrocyte cell lines that display properties of glial scar tissue." Developmental biology. 1993 Sep; 159(1):87-104.
1993 Apr 1
Groves AK, Barnett SC, Franklin RJ, Crang AJ, Mayer M, Blakemore WF, Noble M. "Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells." Nature. 1993 Apr 1; 362(6419):453-5.
1992 Aug
Wolswijk G, Noble M. "Cooperation between PDGF and FGF converts slowly dividing O-2Aadult progenitor cells to rapidly dividing cells with characteristics of O-2Aperinatal progenitor cells." The Journal of cell biology. 1992 Aug; 118(4):889-900.
1992 Jan
Wren D, Wolswijk G, Noble M. "In vitro analysis of the origin and maintenance of O-2Aadult progenitor cells." The Journal of cell biology. 1992 Jan; 116(1):167-76.
1990 Aug
Bögler O, Wren D, Barnett SC, Land H, Noble M. "Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells." Proceedings of the National Academy of Sciences of the United States of America. 1990 Aug; 87(16):6368-72.
1989 Feb
Wolswijk G, Noble M. "Identification of an adult-specific glial progenitor cell." Development. 1989 Feb; 105(2):387-400.
1988 Jun 9
Noble M, Murray K, Stroobant P, Waterfield MD, Riddle P. "Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell." Nature. 1988 Jun 9; 333(6173):560-2.
1988 Jun 9
Raff MC, Lillien LE, Richardson WD, Burne JF, Noble MD. "Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture." Nature. 1988 Jun 9; 333(6173):562-5.
Small RK, Riddle P, Noble M. "Evidence for migration of oligodendrocyte--type-2 astrocyte progenitor cells into the developing rat optic nerve." Nature. 1987 328(6126):155-7.
1984 Oct
Noble M, Murray K. "Purified astrocytes promote the in vitro division of a bipotential glial progenitor cell." The EMBO journal. 1984 Oct; 3(10):2243-7.
Raff MC, Miller RH, Noble M. "A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium." Nature. 1983 303(5916):390-6.