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Patricia Janet Sime, M.D.

Contact Information

Phone Numbers

Office: (585) 275-4161

Fax: (585) 273-1171

Faculty Appointments

Patient Care Setting



Professional Background

Modulation of Pulmonary Inflammation using Gene Transfer Techniques


The Sime lab is focused on studying pulmonary disease and pathologic processes in the lung. Our 2 primary areas of focus include lung scarring, and smoking related diseases such as chronic obstructive pulmonary disease (COPD).

Lung scarring, or pulmonary fibrosis, can be caused by environmental exposures such as silica, asbestos, and radiation, or develop of unknown reasons (Idiopathic pulmonary fibrosis). We are interested in studying the cellular mechanisms involved in the pathogenesis of pulmonary fibrosis to identify novel therapeutic targets.

We are also interested in studying the effects of cigarette and biomass smoke exposure in the lung. Our lab is investigating the mechanisms by which cigarette smoke leads to lung pathologies such as COPD, and dampened anti-viral responses in the lung. Biomass smoke exposure is another common environmental exposure, especially in the developing world, that is associated with lung infection and disease. For our smoking-related projects, we utilize a state-of-the-art smoking facility in the MRBX to expose cells and mice to biomass or cigarette smoke.



BS | UK-U Edinburgh Fac Med

MD | UK-U Edinburgh Fac Med

Post-doctoral Training & Residency

03/01/1998 - 09/30/1999
Fellowship in Pulmonary Disease at The Royal Infirmary of Edinburgh (United Kingdom)

11/01/1993 - 02/28/1998
Fellowship in Pulmonary Disease at Hamilton General Hospital/Hamilton Health Services (Canada)

03/01/1992 - 11/01/1993
Fellowship in Pulmonary Disease at The Royal Infirmary of Edinburgh (United Kingdom)

03/01/1991 - 02/28/1992
Residency in Internal Medicine at Borders General Hospital

08/01/1989 - 02/28/1991
Residency in Internal Medicine at Western General Hospital (Scotland)

08/01/1988 - 07/31/1989
Internship at The Royal Infirmary of Edinburgh (United Kingdom)

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Journal Articles

Rackow AR, Nagel DJ, Zapas G, Clough RS, Sime PJ, Kottmann RM. "The Novel Small Molecule BTB Inhibits Pro-Fibrotic Fibroblast Behavior though Inhibition of RhoA Activity." International journal of molecular sciences.. 2022 Oct 8; 23(19)Epub 2022 Oct 08.

Buckley PF, Sime PJ, Collins L, Eggleston N, Davenport JE. "The Future of Endowed Chairs in Academic Medicine." Academic medicine : journal of the Association of American Medical Colleges.. 2022 Aug 30; Epub 2022 Aug 30.

Nagel DJ, Rackow AR, Ku WY, Bell TJ, Sime PJ, Kottmann RM. "Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Inflammation and Fibrosis; Potential Implications for Idiopathic Pulmonary Fibrosis." Cells.. 2022 Aug 16; 11(16)Epub 2022 Aug 16.