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Patricia Janet Sime, M.D.

Contact Information

Phone Numbers

Office: (585) 275-4161

Fax: (585) 273-1171

Faculty Appointments

Patient Care Setting

Pulmonary

Biography

Professional Background

Modulation of Pulmonary Inflammation using Gene Transfer Techniques

Research

The Sime lab is focused on studying pulmonary disease and pathologic processes in the lung. Our 2 primary areas of focus include lung scarring, and smoking related diseases such as chronic obstructive pulmonary disease (COPD).

Lung scarring, or pulmonary fibrosis, can be caused by environmental exposures such as silica, asbestos, and radiation, or develop of unknown reasons (Idiopathic pulmonary fibrosis). We are interested in studying the cellular mechanisms involved in the pathogenesis of pulmonary fibrosis to identify novel therapeutic targets.

We are also interested in studying the effects of cigarette and biomass smoke exposure in the lung. Our lab is investigating the mechanisms by which cigarette smoke leads to lung pathologies such as COPD, and dampened anti-viral responses in the lung. Biomass smoke exposure is another common environmental exposure, especially in the developing world, that is associated with lung infection and disease. For our smoking-related projects, we utilize a state-of-the-art smoking facility in the MRBX to expose cells and mice to biomass or cigarette smoke.

Credentials

Specialties

  • Internal Medicine
  • Pulmonary Disease

Education

1984
BS | UK-U Edinburgh Fac Med
Pathology

1988
MD | UK-U Edinburgh Fac Med
Medicine

Post-doctoral Training & Residency

11/1/1993 - 02/28/1998
Fellowship in Pulmonary at Mcmaster Univ, Canada

03/01/1998 - 09/30/1999
Fellowship in Pulmonary at Royal Infirmary of Edinburgh

03/01/1992 - 11/01/1993
Fellowship in Pulmonary at Royal Infirmary of Edinburgh

03/01/1991 - 02/28/1992
Residency in General Internal Medicine at Borders General Hospital

08/01/1989 - 02/28/1991
Residency in General Internal Medicine at Western General Hospitals

08/01/1988 - 07/31/1989
Internship in Internal Medicine/General Surgery at Royal Infirmary of Edinburgh

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Patents

Title: LDH Inhibitors as Treatment for Fibrosis and for Fibrotic-Related Disorders
U.S. Serial #: 14/718,933
Filed: May 21, 2015
Invented By: Robert Kottmann, Richard Phipps, Patricia Sime

Publications

Journal Articles

7/2/2018
Duffney PF, Falsetta ML, Rackow AR, Thatcher TH, Phipps RP, Sime PJ. "Key roles for lipid mediators in the adaptive immune response." The Journal of clinical investigation.. 2018 Jul 2; 128(7):2724-2731. Epub 2018 Jul 02.

4/1/2018
Lacy SH, Epa AP, Pollock SJ, Woeller CF, Thatcher TH, Phipps RP, Sime PJ. "Activated human T lymphocytes inhibit TGF?-induced fibroblast to myofibroblast differentiation via prostaglandins D and E." American journal of physiology. Lung cellular and molecular physiology.. 2018 Apr 1; 314(4):L569-L582. Epub 2017 Dec 20.

3/1/2018
Duffney PF, McCarthy CE, Nogales A, Thatcher TH, Martinez-Sobrido L, Phipps RP, Sime PJ. "Cigarette smoke dampens antiviral signaling in small airway epithelial cells by disrupting TLR3 cleavage." American journal of physiology. Lung cellular and molecular physiology.. 2018 Mar 1; 314(3):L505-L513. Epub 2017 Dec 14.

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