Chen Yan, Ph.D.

Chen Yan, Ph.D.

Contact Information

Aab Cardiovascular Research Institute
601 Elmwood Avenue
Rochester, NY 14642

Office: (585) 276-7704
Fax: (585) 276-1530
Lab: (585) 276-7713
Administrative: (585) 276-7698

Journal Articles

Showing all 49 journal articles available.

2007 Oct 12
Surapisitchat J, Jeon KI, Yan C, Beavo JA. "Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3." Circulation research. 2007 Oct 12; 101(8):811-8. Epub 2007 Aug 17.
2007 Aug
Lim JH, Stirling B, Derry J, Koga T, Jono H, Woo CH, Xu H, Bourne P, Ha UH, Ishinaga H, Xu H, Andalibi A, Feng XH, Zhu H, Huang Y, Zhang W, Weng X, Yan C, Yin Z, Briles DE, Davis RJ, Flavell RA, Li JD. "Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections." Immunity. 2007 Aug; 27(2):349-60.
2007 Jul 6
Garin G, Abe J, Mohan A, Lu W, Yan C, Newby AC, Rhaman A, Berk BC. "Flow antagonizes TNF-alpha signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processing." Circulation research. 2007 Jul 6; 101(1):97-105. Epub 2007 May 24.
2007 Mar 2
Yan C, Ding B, Shishido T, Woo CH, Itoh S, Jeon KI, Liu W, Xu H, McClain C, Molina CA, Blaxall BC, Abe J. "Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop." Circulation research. 2007 Mar 2; 100(4):510-9. Epub 2007 Feb 01.
2007 Mar 2
Yan C, Miller CL, Abe J. "Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart." Circulation research. 2007 Mar 2; 100(4):489-501.
2007 Feb 21
Ishinaga H, Jono H, Lim JH, Kweon SM, Xu H, Ha UH, Xu H, Koga T, Yan C, Feng XH, Chen LF, Li JD. "TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation." The EMBO journal. 2007 Feb 21; 26(4):1150-62. Epub 2007 Feb 01.
Chen C, Korshunov VA, Massett MP, Yan C, Berk BC. "Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways." Journal of vascular research. 2007 44(6):504-12. Epub 2007 Jul 30.
2006 May 15
Qin F, Yan C, Patel R, Liu W, Dong E. "Vitamins C and E attenuate apoptosis, beta-adrenergic receptor desensitization, and sarcoplasmic reticular Ca2+ ATPase downregulation after myocardial infarction." Free radical biology & medicine. 2006 May 15; 40(10):1827-42. Epub 2006 Feb 08.
2006 Apr 11
Itoh S, Ding B, Shishido T, Lerner-Marmarosh N, Wang N, Maekawa N, Berk BC, Takeishi Y, Yan C, Blaxall BC, Abe J. "Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium." Circulation. 2006 Apr 11; 113(14):1787-98. Epub 2006 Apr 03.
2006 Mar 31
Nagel DJ, Aizawa T, Jeon KI, Liu W, Mohan A, Wei H, Miano JM, Florio VA, Gao P, Korshunov VA, Berk BC, Yan C. "Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival." Circulation research. 2006 Mar 31; 98(6):777-84. Epub 2006 Mar 02.
2006 Jan 15
Qin F, Patel R, Yan C, Liu W. "NADPH oxidase is involved in angiotensin II-induced apoptosis in H9C2 cardiac muscle cells: effects of apocynin." Free radical biology & medicine. 2006 Jan 15; 40(2):236-46. Epub 2005 Nov 10.
Woo, CH.; Massett, MP.; Shishido, T.; Itoh, S.; Ding, B.; McClain, C.; Che, W.; Vulapalli, SR.; Yan, C.; Abe, J. "ERK5 activation inhibits inflammatory responses via peroxisome proliferators-activated receptor delta (PPARdelta ) stimulation." J. Bio. Chem. 2006; 281: 32164-32174.
2005 Oct 11
Ding B, Abe J, Wei H, Xu H, Che W, Aizawa T, Liu W, Molina CA, Sadoshima J, Blaxall BC, Berk BC, Yan C. "A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis." Proceedings of the National Academy of Sciences of the United States of America. 2005 Oct 11; 102(41):14771-6. Epub 2005 Sep 26.
2005 Oct
Vasta V, Sonnenburg WK, Yan C, Soderling SH, Shimizu-Albergine M, Beavo JA. "Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm." Biology of reproduction. 2005 Oct; 73(4):598-609. Epub 2005 May 18.
2005 Jul 29
Yin G, Zheng Q, Yan C, Berk BC. "GIT1 is a scaffold for ERK1/2 activation in focal adhesions." The Journal of biological chemistry. 2005 Jul 29; 280(30):27705-12. Epub 2005 May 27.
2005 Jun 24
Itoh S, Ding B, Bains CP, Wang N, Takeishi Y, Jalili T, King GL, Walsh RA, Yan C, Abe J. "Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation." The Journal of biological chemistry. 2005 Jun 24; 280(25):24135-42. Epub 2005 Apr 19.
2005 May 17
Ding B, Abe J, Wei H, Huang Q, Walsh RA, Molina CA, Zhao A, Sadoshima J, Blaxall BC, Berk BC, Yan C. "Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure." Circulation. 2005 May 17; 111(19):2469-76. Epub 2005 May 02.
2005 Jan
Kim D, Aizawa T, Wei H, Pi X, Rybalkin SD, Berk BC, Yan C. "Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling." Journal of molecular and cellular cardiology. 2005 Jan; 38(1):175-84. Epub 2004 Dec 08.
Pi, X.; Garin, G.; Xie, L.; Zheng, Q.; Wei, H.; Abe, J.; Yan, C.; Berk, BC. "BMK1/ERK5 Is a Novel Regulator of Angiogenesis by Destabilizing Hypoxia Inducible Factor 1{alpha}." Circulation Research. 2005; 96(1145-1151).
Shen, W.; Gao, P.; Che, Z.; Ji, K.; Yin, M.; Yan, C.; Berk, BC.; Zhu, D. "NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation." Biochemical and Biophysical Research Communication. 2005; 339: 337-343.
Yan C. "Determination of Ca2+/calmodulin-stimulated phosphodiesterase activity in intact cells." Methods in molecular biology. 2005 307:85-92.
2004 Oct
Akaike M, Che W, Marmarosh NL, Ohta S, Osawa M, Ding B, Berk BC, Yan C, Abe J. "The hinge-helix 1 region of peroxisome proliferator-activated receptor gamma1 (PPARgamma1) mediates interaction with extracellular signal-regulated kinase 5 and PPARgamma1 transcriptional activation: involvement in flow-induced PPARgamma activation in endothelial cells." Molecular and cellular biology. 2004 Oct; 24(19):8691-704.
2004 Oct
Melaragno MG, Cavet ME, Yan C, Tai LK, Jin ZG, Haendeler J, Berk BC. "Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt." Journal of molecular and cellular cardiology. 2004 Oct; 37(4):881-7.
2004 May 21
Cameron SJ, Itoh S, Baines CP, Zhang C, Ohta S, Che W, Glassman M, Lee JD, Yan C, Yang J, Abe J. "Activation of big MAP kinase 1 (BMK1/ERK5) inhibits cardiac injury after myocardial ischemia and reperfusion." FEBS letters. 2004 May 21; 566(1-3):255-60.
2004 Mar 5
Zheng Q, Yin G, Yan C, Cavet M, Berk BC. "14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function." The Journal of biological chemistry. 2004 Mar 5; 279(10):8787-91. Epub 2003 Dec 16.
2004 Feb 20
Pi X, Yan C, Berk BC. "Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis." Circulation research. 2004 Feb 20; 94(3):362-9. Epub 2003 Dec 11.
2004 Jan
Yin G, Haendeler J, Yan C, Berk BC. "GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor." Molecular and cellular biology. 2004 Jan; 24(2):875-85.
Osawa, M.; Itoh, S.; Ohta, S.; Huang, Q.; Berk, BC.; Marmarosh, NL.; Che, W.; Ding, B.; Yan, C.; Abe, J. "ERK1/2 associates with the c-Met binding domain of Gab1: Role in ERK1/2 and Egr-1 nuclear accumulation." J Biol. Chem. 2004; 79(28): 29691-29699.
2003 Dec 12
Haendeler J, Yin G, Hojo Y, Saito Y, Melaragno M, Yan C, Sharma VK, Heller M, Aebersold R, Berk BC. "GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor." The Journal of biological chemistry. 2003 Dec 12; 278(50):49936-44. Epub 2003 Sep 30.
2003 Oct 1
Lerner-Marmarosh N, Yoshizumi M, Che W, Surapisitchat J, Kawakatsu H, Akaike M, Ding B, Huang Q, Yan C, Berk BC, Abe J. "Inhibition of tumor necrosis factor-[alpha]-induced SHP-2 phosphatase activity by shear stress: a mechanism to reduce endothelial inflammation." Arteriosclerosis, thrombosis, and vascular biology. 2003 Oct 1; 23(10):1775-81. Epub 2003 Aug 28.
2003 Sep 5
Aizawa T, Wei H, Miano JM, Abe J, Berk BC, Yan C. "Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells." Circulation research. 2003 Sep 5; 93(5):406-13. Epub 2003 Aug 14.
2003 Aug 22
Rybalkin SD, Yan C, Bornfeldt KE, Beavo JA. "Cyclic GMP phosphodiesterases and regulation of smooth muscle function." Circulation research. 2003 Aug 22; 93(4):280-91.
2003 Jun
Yin G, Yan C, Berk BC. "Angiotensin II signaling pathways mediated by tyrosine kinases." The international journal of biochemistry & cell biology. 2003 Jun; 35(6):780-3.
2003 May 16
Cameron SJ, Malik S, Akaike M, Lerner-Marmarosh N, Yan C, Lee JD, Abe J, Yang J. "Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation." The Journal of biological chemistry. 2003 May 16; 278(20):18682-8. Epub 2003 Mar 12.
2003 Jan 1
Yan C, Kim D, Aizawa T, Berk BC. "Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator." Arteriosclerosis, thrombosis, and vascular biology. 2003 Jan 1; 23(1):26-36.
2002 Nov 1
Tai LK, Okuda M, Abe J, Yan C, Berk BC. "Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway." Arteriosclerosis, thrombosis, and vascular biology. 2002 Nov 1; 22(11):1790-6.
2002 Aug 9
Huang Q, Lerner-Marmarosh N, Che W, Ohta S, Osawa M, Yoshizumi M, Glassman M, Yan C, Berk BC, Abe J. "The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation." The Journal of biological chemistry. 2002 Aug 9; 277(32):29330-41. Epub 2002 May 14.
2002 Jun 14
Che W, Lerner-Marmarosh N, Huang Q, Osawa M, Ohta S, Yoshizumi M, Glassman M, Lee JD, Yan C, Berk BC, Abe J. "Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression." Circulation research. 2002 Jun 14; 90(11):1222-30.
Berk, BC.; Wang, M.; Yan, C.; Surapisitchat, J.; Hoefen, R. "Atheroprotective Mechanisms Activated by Sheer Stress in Endothelial Cells." Drug News Perspect. 2002; 15: 1-7.
Pi, X.; Yan, C.; Kim, D-S.; Chen, J.; Berk, BC. "Differential expression of genes from nitrate tolerant rat aortas." Journal of Vascular Resarch. 2002; 39: 304-310.
Frame, MD.; Fox, RJ.; Kim, D-S.; Mohan, A.; Berk, BC.; Chen, Y. "Diminished arteriolar responses in nitrate tolerance involve ROS and angiotensin II." Am. J. Physiol. 2002; 282: H2377-H2385.
2001 Dec
Berk BC, Abe JI, Min W, Surapisitchat J, Yan C. "Endothelial atheroprotective and anti-inflammatory mechanisms." Annals of the New York Academy of Sciences. 2001 Dec; 947:93-109; discussion 109-11.
2001 Nov 6
Kim D, Rybalkin SD, Pi X, Wang Y, Zhang C, Munzel T, Beavo JA, Berk BC, Yan C. "Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance." Circulation. 2001 Nov 6; 104(19):2338-43.
2001 Nov
Takeishi Y, Huang Q, Wang T, Glassman M, Yoshizumi M, Baines CP, Lee JD, Kawakatsu H, Che W, Lerner-Marmarosh N, Zhang C, Yan C, Ohta S, Walsh RA, Berk BC, Abe J. "Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation of MAP kinases activation by ischemic preconditioning." Journal of molecular and cellular cardiology. 2001 Nov; 33(11):1989-2005.
2001 Sep 18
Che W, Abe J, Yoshizumi M, Huang Q, Glassman M, Ohta S, Melaragno MG, Poppa V, Yan C, Lerner-Marmarosh N, Zhang C, Wu Y, Arlinghaus R, Berk BC. "p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells." Circulation. 2001 Sep 18; 104(12):1399-406.
2001 Jun
Yan C, Zhao AZ, Sonnenburg WK, Beavo JA. "Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis." Biology of reproduction. 2001 Jun; 64(6):1746-54.
2001 Apr 6
Yan C, Luo H, Lee JD, Abe J, Berk BC. "Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains." The Journal of biological chemistry. 2001 Apr 6; 276(14):10870-8. Epub 2001 Jan 03.
2001 Jan 15
Cavanaugh JE, Ham J, Hetman M, Poser S, Yan C, Xia Z. "Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Jan 15; 21(2):434-43.
Surapisitcht, J.; Hoefen, JR.; Pi, X.; Yoshizumi, M.; Yan, C.; Berk, BC. "Fluid shear stress inhibits TNF-a activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells : inhibitory crosstalk among MAPK family members." Proc. Nat. Acad, Sci. USA. 2001; 98: 6476-6481.


Yan C, Nagel DJ, Jeon K. "Regulation and Function of Cyclic Nucleotide Phosphodiesterases in Vascular Smooth Muscle and Vascular Diseases.". Cyclic Nucleotide Phosphodiesterases in Health and Disease. Joseph Beavo, Sharron Francis, and Miles Houslay. : CRC Press, 2006.
Yan C.. "Determination of Ca2+/Calmodulin-Stimulated Phosphodiesterase Activity in Intact Cells". Methods Mol Biol. : N/A, 2005. 85-92
Jin Z-G, Liao D-F, Yan C, and Berk BC. "Identification of secreted oxidative stress-induced factors (SOXF) and associated proteins: proteomics in vascular biology". In Proteomic and Genomic Analysis of Cardiovascular Disease. Jennifer Van Eyk and Michael J. Dunn. : Wiley-VCH publishers, 2003.
Berk BC, Surapisitchat J, Yoshizumi M, Yan C. Hoefen R, and Abe J. "Atheroprotective mechanisms of fluid shear stress: nitric oxide independent inhibition of signal transduction mediated by inflammatory cytokine". Vascular Endothelium-Source and Target of Inflammatory Mediators. J. D. Catravas, A. D. Callow, U. S. Ryan, and M. Simionescu.. : IOS Press, 2001. 115-125
Surapisitchat J, Yan C, and Berk BC. "Flow-mediated Activation of MAP Kinase". Vascular Protection: Molecular Mechanisms, Novel Therapeutic Principles, and Cli. Gabor M. Rubanyi, Victor J. Dzau, and John P. Cooke. : N/A, 2001. 167-164
Abe J, Yan C, Surapisitchat J, and Berk BC. "Kinase Signaling in the Cardiovascular System". Heart Physiology and Pathophysiology. Nicholas Sperelakis et al.. : Academic Press, 2000. 2146-2199
Traub O, Yan C, and Berk BC. "In Vitro stimulation of shear stress and mitogen-activated protein kinase responses to shear stress in endothelial cells". Mechanical Forces and the Endothelium. Peter Lelkes. : Hardwood Academic Publishers., 1998. 89-126
Zhao AZ, Yan C, Sonnenburg WK, and Beavo JA. "Recent advances in the study of Ca2+/CaM activated phosphodiesterases: Expression and physiological functions". Signal Transduction in Health and Disease, Advances in Second Messenger and P.... Corbin, J. and Francis, S.. : Raven Press, 1997. 237-251
Yan C, Chan GC, Storm DR, and Beavo JA. "cAMP Phosphodiesterase / Adenylate Cyclase". Calcium as a Cellular Regulator. Klee, C. and E. Carafoli. : Oxford University Press, 1997.