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Mark A. Sullivan, Ph.D.

Contact Information

Phone Numbers

Fax: (585) 276-0190

Office: (585) 273-1629

Biography

Research

The ability to rapidly isolate human antibodies using phage display has opened up new approaches to understanding protein function. Research in my laboratory is focused on the manipulation of immunoglobulin molecules to develop novel reagents for characterization of protein expression and structure. We are using phage antibody technology in several areas of proteomics research to develop improved reagents for protein characterization as well as novel inhibitors of protein function that will aid in defining the roles of the many new proteins discovered through genomic sequencing. Major efforts are aimed at dissecting the saliva proteome and developing panels of antibodies for incorporation into new diagnostic platforms using protein microarrays. A second initiative is to derive antibodies useful for solving the structure of proteins by X-ray crystallography. Additional studies focus on the therapeutic potential of single-chain antibodies to reduce protein aggregation and misfolding, a process that characterizes a variety of neurodegenerative diseases.

Credentials

Faculty Appointments

Education

1975
BS | Purdue University
Chemistry

1981
PhD | Univ Wisconsin-Madison
Biochemistry

Awards

1990
C.E.K. Mees Award for Excellence in Scientific Research and Reporting
Sponsor: Eastman Kodak Company

1976 - 1979
NIH Predoctoral Fellowship
Sponsor: University of Wisconsin

1975 - 1976
Wisconsin Alumni Research Foundation Fellowship
Sponsor: University of Wisconsin

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Patents

Title: Protease Activated Cytokines
U.S. Serial #: 13/639,006
Filed: Mar 31, 2011
Invented By: JohnFrelinger, BaekKim, JohnPuskas, MarkSullivan

Publications

Journal Articles

12/21/2015
Ravichandran S, Sullivan MA, Callahan LM, Bentley KL, DeLouise LA. "Development and characterization of antibody reagents for detecting nanoparticles." Nanoscale.. 2015 Dec 21; 7(47):20042-54. Epub 2015 Nov 16.

4/29/2014
Piekna-Przybylska D, Sullivan MA, Sharma G, Bambara RA. "U3 region in the HIV-1 genome adopts a G-quadruplex structure in its RNA and DNA sequence." Biochemistry.. 2014 Apr 29; 53(16):2581-93. Epub 2014 Apr 15.

3/12/2013
Sullivan MA, Brooks LR, Weidenborner P, Domm W, Mattiacio J, Xu Q, Tiberio M, Wentworth T, Kobie J, Bryk P, Zheng B, Murphy M, Sanz I, Dewhurst S. "Anti-idiotypic monobodies derived from a fibronectin scaffold." Biochemistry.. 2013 Mar 12; 52(10):1802-13. Epub 2013 Mar 01.

Books & Chapters

1996
Chapter Title: Antibody engineering for immunodiagnostics.
Book Title: Antibody Engineering: New Technologies, Applications, and Commercialization
Author List: Sullivan MA, Malone J.
Published By: IBC Medical Library1996 in Southborough, MA

1987
Chapter Title: Isolation and characterization of the gene encoding hypoxanthine-guanine phosphoribosyl transferase from Plasmodium falciparum.
Book Title: UCLA Symposia on Molecular and Cellular Biology, New Series
Author List: Sullivan MA, Lloyd DB, Holland LE.
Edited By: Agabian N, Goodman H, Nogueira N
Published By: Alan R. Liss, Inc.1987 in New York

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