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Carol L. Miller-Graziano, Ph.D.


Showing all 69 journal articles & 16 books available

Journal Articles

Laudanski K, Miller-Graziano C, Xiao W, Mindrinos MN, Richards DR, De A, Moldawer LL, Maier RV, Bankey P, Baker HV, Brownstein BH, Cobb JP, Calvano SE, Davis RW, Tompkins RG. "Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways." Proceedings of the National Academy of Sciences of the United States of America.. 2006 Oct 17; 103(42):15564-9. Epub 2006 Oct 10.

Bandyopadhyay, G.; De, A.; Laudanski, K.; Li F.; Lentz, C.; Bankey, P.; Miller-Graziano, C. "Negative Signaling Contributes to T Cell Anergy in Trauma Patients". Crit. Care Med. 2006; .

Laudanski K, De A, Pellegrini J, Miller-Graziano C. "Simultaneous aberrations in Mphi and T cell function adversely affect trauma patients' clinical outcome: a possible faulty IL-13 feedback loop." Clinical immunology : the official journal of the Clinical Immunology Society.. 2006 118(2-3):332-41. Epub 2005 Nov 21.

De AK, Miller-Graziano CL, Calvano SE, Laudanski K, Lowry SF, Moldawer LL, Remick DG, Rajicic N, Schoenfeld D, Tompkins RG. "Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation." The Journal of immunology : official journal of the American Association of Immunologists.. 2005 Nov 1; 175(9):6155-62.

Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, Miller-Graziano C, Moldawer LL, Mindrinos MN, Davis RW, Tompkins RG, Lowry SF, . "A network-based analysis of systemic inflammation in humans." Nature.. 2005 Oct 13; 437(7061):1032-7. Epub 2005 Aug 31.

Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson CM, Hayden DL, Herndon DN, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tompkins RG, Baker HV, Bankey P, Billiar T, Brownstein BH, Calvano SE, Camp D, Chaudry I, Cobb JP, Davis RW, Elson CM, Freeman B, Gamelli R, Gibran N, Harbrecht B, Hayden DL, Heagy W, Heimbach D, Herndon DN, Horton J, Hunt J, Laudanski K, Lederer J, Lowry SF, Maier RV, Mannick J, McKinley B, Miller-Graziano C, Mindrinos MN, Minei J, Moldawer LL, Moore E, Moore F, Munford R, Nathens A, O'keefe G, Purdue G, Rahme L, Remick D, Sailors M, Schoenfeld DA, Shapiro M, Silver G, Smith R, Stephanopoulos G, Stormo G, Tompkins RG, Toner M, Warren S, West M, Wolfe S, Xiao W, Young V, . "Application of genome-wide expression analysis to human health and disease." Proceedings of the National Academy of Sciences of the United States of America.. 2005 Mar 29; 102(13):4801-6. Epub 2005 Mar 21.

De AK, Roach SE, De M, Minielly RC, Laudanski K, Miller-Graziano CL, Bankey PE. "Development of a simple method for rapid isolation of polymorphonuclear leukocytes from human blood." Journal of immunoassay & immunochemistry. 2005 26(1):35-42.

Feezor RJ, Baker HV, Mindrinos M, Hayden D, Tannahill CL, Brownstein BH, Fay A, MacMillan S, Laramie J, Xiao W, Moldawer LL, Cobb JP, Laudanski K, Miller-Graziano CL, Maier RV, Schoenfeld D, Davis RW, Tompkins RG, . "Whole blood and leukocyte RNA isolation for gene expression analyses." Physiological genomics.. 2004 Nov 17; 19(3):247-54.

Laudanski K, De A, Brouxhon S, Kyrkanides S, Miller-Graziano C. "Abnormal PGE(2) regulation of monocyte TNF-alpha levels in trauma patients parallels development of a more macrophage-like phenotype." Shock.. 2004 Sep 0; 22(3):204-12.

Koniaris, L.G.; Kaufman, D.; Zimmers, T.A.; Wang, N.; Spitalnik, P.F.; Henson, L.; Miller-Graziano, C.; Sitzmann, J.V. "Two Third-Year Medical Student-Level Laboratory Shock Exercises without Large Animals". Surgical Infections. 2004; 5 (4): 34.

De AK, Laudanski K, Miller-Graziano CL. "Failure of monocytes of trauma patients to convert to immature dendritic cells is related to preferential macrophage-colony-stimulating factor-driven macrophage differentiation." The Journal of immunology : official journal of the American Association of Immunologists.. 2003 Jun 15; 170(12):6355-62.

Sheth K, Friel J, Nolan B, Miller-Graziano C, Bankey P. "Down-regulated circulating PMN function after injury despite enhanced p38 MAPK activity." Surgical infections.. 2002 3(2):151-7,discussion 157-8.

De AK, Kodys KM, Yeh BS, Miller-Graziano C. "Exaggerated human monocyte IL-10 concomitant to minimal TNF-alpha induction by heat-shock protein 27 (Hsp27) suggests Hsp27 is primarily an antiinflammatory stimulus." The Journal of immunology : official journal of the American Association of Immunologists.. 2000 Oct 1; 165(7):3951-8.

De, A.; Kodys, K.; Pellegrini, J.; Yeh, B.; Furse, R.; Bankey, P.; Miller-Graziano, C. "Induction of Global Anergy Rather than Inhibitory Th2 Lymphokines Mediate Post-Trauma T Cell Immunodepression". Clin. Immun. 2000; 96(1): 52-66.

Pellegrini, J.D.; De, A.K.; Kodys, K.; Puyana, J.C.; Furse, R.K.; Miller-Graziano, C. "Relationships Between T Lymphocyte Apoptosis and Anergy Following Trauma". J. of Surgical Research. 1999; 88: 200-206.

Miller, C.; De, A.; Yeh, B.; Kodys, K. "Failure of GM-CSF/IL-4 Induced MØ to Become Dendritic Cells Reflects Altered Signal Transduction and Altered TNF(alpha) and CD64 Levels". J. Leuk. Biol. 1999; Suppl.: 18.

De AK, Kodys K, Miller-Graziano C. "Maximal T cell IL-13 production requires monocyte or monokine participation." Cytokine.. 1998 Dec 0; 10(12):911-9.

Puyana, J.C.; Pellegrini, J.D.; De, A.K.; Kodys, K.; Silva, W.E.; Miller, C.L. "Both T Helper-1 and T Helper-2 Type Lymphokines are Depressed in Post Trauma Anergy". J. of Trauma. 1998; 44(6): 1037-1046.

De, A.K.; Kodys, K.; Furse, R.K.; Pellegrini, J.; Puyana, J.C.; Miller-Graziano, C.L. "Anergy of T Cells Induced by Trauma and Sepsis". Surgery & Critical Care. 1998; : 30-31.

De AK, Kodys K, Puyana JC, Fudem G, Pellegrini J, Miller-Graziano CL. "Only a subset of trauma patients with depressed mitogen responses have true T cell dysfunctions." Clinical immunology and immunopathology. 1997 Jan 0; 82(1):73-82.

Furse, R.K.; Kodys, K.; Zhu, D.; Miller-Graziano, C.L. "Increased MØ TNF(alpha) Message Stability Contributes to Trauma Patients' Increased TNF Production". J. Leuk. Biol. 1997; 62: 524-534.

Pellegrini JD, Puyana JC, Lapchak PH, Kodys K, Miller-Graziano CL. "A membrane TNF-alpha/TNFR ratio correlates to MODS score and mortality." Shock.. 1996 Dec 0; 6(6):389-96.

Pellegrini, J.; Puyana, J.C.; De, A.K.; Fudem, G.; Kodys, K.; and Lapchak, P.H.; Miller, C. "A Trauma Induced T Cell Defect is Associated with Deregulated Monokine Production and is Truly Predictive of Poor Clinical Outcome". Surgical Forum. 1996; XLVII: 64-66.

Miller-Graziano, C.; De, A.K.; Kodys, K. "Post-Trauma Depressed IFN(gamma) Production Result from Elevated MØ PGE2 Production and/or a True T Cell Dysfunction". Clinical Immunol & Immunopath. 1995; 75(3): 292.

Miller-Graziano, C.; De, A.K.; Kodys, K. "Altered IL-10 Levels in Trauma Patients' Monocytes (MØ) and T Lymphocytes". J Clinical Immunology. 1995; 15(2): 93-104.

Miller-Graziano CL, Kodys K, Gonzalez F, Fudem GM. "Continued tumor necrosis factor receptor expression by trauma patients' monocytes (Mphi) despite TNF alpha secretion." Shock.. 1994 May 0; 1(5):317-24.

Miller-Graziano CL, Zhu D, Kodys K. "Differential induction of human monocyte transforming growth factor beta 1 production and its regulation by interleukin 4." Journal of clinical immunology.. 1994 Jan 0; 14(1):61-72.

Miller-Graziano, C.L.; Kodys, K.; Jhaver, K. "Normal MØ Cell-Associated TNFa is Resistant to PGE2 as well as TGF-beta Downregulation". Annals of the NY Academy of Sciences, Microbial Pathogenesis and Immune Response. 1994; 730: 307-309.

Szabo, G.; Kodys, K.; Miller-Graziano, C.L. "Dibutyryl-cAMP Modulation of Receptor Expression and Antigen Presentation Capacity in MØ Subpopulations". Intl J. Immunopharm., England. 1994; 16(2): 151-16.

Miller-Graziano CL, Szabo G, Griffey K, Mehta B, Kodys K, Catalano D. "Role of elevated monocyte transforming growth factor beta (TGF beta) production in posttrauma immunosuppression." Journal of clinical immunology.. 1991 Mar 0; 11(2):95-102.

Miller-Graziano, C.; Pajor, L.; Kodys, K. "Downregulation of TNFR by Fc(gamma)RI Crosslinking and Relationship to Cell Associated Bioactivity". Journal of Leukocyte Biology. 1991; (2): 96-97.

Szabo, G.; Kodys, K.; Miller-Graziano, C.L. "Elevated MØ IL-6 Production in Immunosuppressed Trauma Patients. I. Role of Fc(gamma)RI Crosslinking Stimulation". J. Clinical Immunol. 1991; 11(6): 326-335.

Szabo, G.; Kodys, K.; Miller-Graziano, C.L. "Elevated MØ IL-6 Production in Immunosuppressed Trauma Patients. II. Downregulation by IL-4". J. Clinical Immunology. 1991; 11(6): 336-344.28.

Miller-Graziano CL, Szabo G, Kodys K, Griffey K. "Aberrations in post-trauma monocyte (MO) subpopulation: role in septic shock syndrome." The Journal of trauma.. 1990 Dec 0; 30(12 Suppl):S86-96.

Szabo G, Miller-Graziano CL. "Induction and regulation of monocyte procoagulant activity." Transplantation.. 1990 Aug 0; 50(2):301-9.

Szabo G, Miller-Graziano CL, Wu JY, Takayama T, Kodys K. "Differential tumor necrosis factor production by human monocyte subsets." Journal of leukocyte biology.. 1990 Mar 0; 47(3):206-16.

Szabo G, Miller CL, Kodys K. "Antigen presentation by the CD4 positive monocyte subset." Journal of leukocyte biology.. 1990 Feb 0; 47(2):111-20.

Takayama TK, Miller C, Szabo G. "Elevated tumor necrosis factor alpha production concomitant to elevated prostaglandin E2 production by trauma patients' monocytes." Archives of surgery.. 1990 Jan 0; 125(1):29-35.

Zappala, S.; Khauli, R.; Miller-Graziano, C., et al. "Evaluation of MØ Procoagulant Activity as a Parameter for Immunological Monitoring in Renal Transplantation". Transplant. 1989; 21: 1844.

Miller-Graziano, C.; Fink, M.; Wu, J.; Szabo, G.; Kodys, K. "Mechanisms of Altered Monocyte Prostaglandin E2 Production in Severely Injured Patients". Arch. Surgery. 1988; 123: 293-299.

Miller-Graziano, C.; Fink, M.; Wu, J.; Szabo, G.; Kodys, K. "Mechanisms of Altered Monocyte Prostaglandin E2 Production in Severely Injured Patients". Arch. Surgery. 1988; 123: 293-299.

Miller-Graziano, C.; Lim, R. "Post-Ischemia Immunosuppression in a Mini-Swine Model". Journal of Lab Animal Science. 1986; 36: 375-380.

Miller-Graziano, C.; Lim, R. "Dextran as Modulator of Immune Function in Trauma Patients". Journal of Surgery Res. 1985; 39: 183-191.

Gold, M.; Miller-Graziano, C.; Mishell, R. "Soluble Non-Cross Linked Peptidoglycan Polymers Stimulate Monocyte/Macrophage Inflammatory Function". Infect. and Immun. 1985; 49: 731-741.

Gold, M.; Miller-Graziano, C.; Mishell, R. "Soluble Non-Cross Linked Peptidoglycan Polymers Stimulate Monocyte/Macrophage Inflammatory Function". Infect. And Immun. 1985; 49: 731-741.

Kudsk KA, Miller CL, Sheldon GF. "Adrenalectomy in the guinea pig: operative and perioperative management." Laboratory animal science. 1983 Apr 0; 33(2):177-80.

Miller CL, Graziano CJ, Lim RC. "Human monocyte plasminogen activator production: correlation to altered M phi-T lymphocyte interaction." The Journal of immunology : official journal of the American Association of Immunologists.. 1982 May 0; 128(5):2194-200.

Miller-Graziano, C.; Graziano, C.; Lim, R.; Chin, M. "Production of Tissue Procoagulant Factor by Patient MØ. Correlation to Thromboembolic Complication". Thrombosis and Hemostasis. 1981; 46(2): 489.

Miller-Graziano, C. "The Immune Response of Burn Injury". Journal of Trauma. 1981; 21(8): 677.

Miller, C. "Effect of Nutrition on Nonspecific Inflammatory and Specific Immune Host Defense Systems". J Medicine. 1980; 11(4): 267.

Graziano, C.; Miller, C.; Lim, R. "The Role of Monocyte Function in Alteration of the Thrombo-fibrinolytic System After Shock". Surgical Forum. 1980; XXXI: 24.

Miller CL. "Burns and the immune network." The Journal of trauma.. 1979 Nov 0; 19(11 Suppl):880-3.

Miller CL, Baker CC. "Development of inhibitory macrophage (phi) after splenectomy." Transplantation proceedings.. 1979 Jun 0; 11(2):1460.

Baker CC, Miller CL, Trunkey DD, Lim RC. "Identity of mononuclear cells which compromise the resistance of trauma patients." The Journal of surgical research.. 1979 May 0; 26(5):478-87.

Miller, C.; Claudy, B. "Suppressor T Cells Induced by Thermal Injury". Cellular Immunol. 1979; 44: 201.

Miller, C.; Baker, C. "Changes in Lymphocyte Activity After Thermal Injury: Role of Suppressor Cells". Journal of Clinical Investigations. 1979; 63: 202.

Miller, C. "Immunological Assays as Measurements of Nutritional Status. A Review". Journal of Parenteral and Enteral Nutrition. 1979; 2: 554.

Baker, C.; Miller, C.; Trunkey, D. "Predicting Sepsis in Burn Patients". Journal of Trauma. 1979; 19: 20.

Baker CC, Miller CL, Trunkey DD. "Correlation of traumatic shock with immunocompetence and sepsis." Surgical forum.. 1979 30:20-1.

Miller CL, Graziano C, Lim RC. "Alterations in monocyte function following trauma." Surgical forum.. 1979 30:43-5.

Miller C, Petersen S, Sheldon GF, Carpenter G, Fuchs R, Claudy B. "Effect of protein-sparing therapy on immunocompetence in normal and protein-depleted rats." Surgical forum.. 1978 29:63-5.

Miller CL, Trunkey DD. "Thermal injury: defects in immune response induction." The Journal of surgical research.. 1977 Jun 0; 22(6):621-5.

Miller C, Sheldon GF, Claudy B, Carpenter G. "Evaluation of total parenteral nutrition by in vitro measurement of immune capacity." Surgical forum.. 1977 28:81-2.

Miller, C.; Mishell, R. "Inhibition of Cell Mediated Cytotoxicity by an Adherent Accessory Cell". Journal of Immunology. 1975; 114: 792.

Miller CL, DeWitt CW. "The effect of neonatal thymectomy on antibody responses to histocompatibility antigens in the rat." Cellular immunology.. 1974 Aug 0; 13(2):278-87.

Miller, C.; DeWitt, C. "Cellular and Humoral Response to Major and Minor Histocompatibility Antigens". Transplantation Proceedings. 1974; 1: 303.

Miller C, DeWitt C. "Rat alloantibody responses against strong and weak histocompatibility antigens." The Journal of immunology : official journal of the American Association of Immunologists.. 1972 Nov 0; 109(5):919-26.

DeWitt CW, McDonald JH, Miller C. "Spatial relationships of rat histocompatibility antigens." Transplantation proceedings.. 1971 Mar 0; 3(1):198-201.

Laudanski, K., De, A., Miller-Graziano, C. "Exogenous heat shock protein (Hsp-27) uniquely blocks in vitro IL-4+GM-CSF stimulated MO differentiation to dendritic cells". European Journal of Immunology. .

Books & Chapters

Chapter Title: HSP-27 As an Anti-Inflammatory Protein
Book Title: Molecular Chaperones and Cell Signalling
Author List: Laudanski K, De A, Miller-Graziano C
Edited By: B.Henderson, G.Pockley
Published By: Cambridge Univ Press2005 in New York, NY

Chapter Title: Trauma Mediators Favor Differentiation of Monocytes to Macrophage Rather Than to Dendritic Cells
Book Title: Update in Intensive Care and Emergency Medicine
Author List: Miller-Graziano, C.L.; De, A.K.; Kodys, K.
Edited By: J.C.Marshall, J.Cohen
Published By: Springer-Verlag2000 in Berlin, Germany

Chapter Title: Relationship of Post-Trauma Altered IL-12 and IL-10 to Depressed Patient Mitogen Responses
Book Title: The Immune Consequences of Trauma, Shock & Sepsis - Mechanisms & Therapeutic App
Author List: De, A.K.; Kodys, K.; Fairfield, S.; Miller-Graziano, C.
Edited By: E.Faist
Published By: Springer-Verlag1996 in Berlin, Germany

Chapter Title: Immunology of Shock and Injury
Book Title: Shock and Resuscitation
Author List: Miller-Graziano, C.L.
Edited By: E. Geller
Published By: McGraw-Hill, Inc.1993 in New York.

Chapter Title: Interactions of Immunopathological Mediators (TNF-alpha, TGF-beta, PGE2) in Traumatized Individuals
Book Title: Host Defense Dysfunction in Trauma, Shock and Sepsis
Author List: Miller-Graziano, C.L.; Szabo, G.; Kodys, K.; et al
Edited By: E. Faist
Published By: Springer-Verlag1993 in Berlin, Germany

Chapter Title: Trauma and the Immune System
Book Title: Medicolegal Controversies of Trauma
Author List: Romain, P.L.; Miller-Graziano, C.L.; Zurier, R.B.
Edited By: Simon, W.H.; Ehrligh, G.
Published By: Marcel Dekker, Inc.1992 in New York

Chapter Title: The Immune Consequences of Trauma, Shock and Sepsis
Book Title: Alterations of Monocyte Function Following Major Injury
Author List: Miller-Graziano, C.; Szabo, G.; Takayama, T.; Wu
Edited By: E.Faist
Published By: JSpringer-Verlag1989 in Berlin, Germany

Chapter Title: Splanchnic Ischemia and Multiple Organ Failure
Book Title: Immunologic Consequences
Author List: Miller-Graziano, C.; et al
Edited By: Fiddian-Green, R.,
Published By: Edward Arnold Co., Inc.1989 in Baltimore

Chapter Title: Massive Transfusion in Surgery and Trauma
Book Title: Infection in Massively Injured Patients.
Author List: Miller-Graziano, C.
Edited By: Collins JA, Murawski K,
Published By: Alan R. Liss, Inc.1982 in New York

Chapter Title: Immunobiology of Sepsis
Book Title: Surgical Infections
Author List: Miller-Graziano, C.; Trunkey, D.
Edited By: Flint, L.
Published By: Medical Examination Publishing Co., Inc.1982 in New York.

Chapter Title: Post-Splenectomy Sepsis
Book Title: Surgical Infections
Author List: Trunkey, D.; Miller-Graziano, C.
Edited By: Flint, L.
Published By: Medical Examination Publishing Co.,1982 in New York

Chapter Title: Multiple Organ Failure and Sepsis
Book Title: Emergency Surgery
Author List: Trunkey, D.; Miller-Graziano, C.
Edited By: Najarian, J., Delaney, J.
Published By: Year Book Publishers1982 in Chicago

Chapter Title: Immune Consequences of Trauma
Book Title: Surgical Clinics of North America: Trauma
Author List: Miller, S.; Miller-Graziano, C.; Trunkey, D.
Edited By: Trunkey D
Published By: WB Saunders Co.1982

Chapter Title: Secondary Immunodeficiency in Burns and After Surgical Trauma
Book Title: Clinics in Immunology and Allergy
Author List: Miller-Graziano, C.
Edited By: Webster A
Published By: WB Saunders Co., Ltd.,1981 in Philadelphia

Chapter Title: Alteration in Macrophage Function Following Thermal Injury
Book Title: Immune Consequences of Thermal Injury
Author List: Miller, C.
Edited By: Ninnemann, J.
Published By: Williams and Wilkins1980 in Maryland

Chapter Title: Effects of Accessory Cells on the Generation of Immune Responses
Book Title: Lymphocytes and Their Interaction.
Author List: Mishell, R.; Miller, C.
Edited By: Williams, R.
Published By: Raven Press1974 in New York