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Jing Wang, B.Med., Ph.D.

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Biography

Research

1. Macrophage mediated fungal clearance and lung injury during
Pneumocystis pneumonia
2. Mechanism of immune mediated lung injury during infectious diseases
3. Seeking new strategies to treat inflammatory lung diseases

Pneumocystis is an opportunistic fungal respiratory pathogen that causes life-threatening pneumonia in patients suffering from defects in cell-mediated immunity, including those with acquired immunodeficiency syndrome (AIDS) and immunosuppression secondary to chemotherapy or organ transplantation. Despite dramatic advances in health care and the availability of antibiotics to treat this infection, mortality rates have improved little over the past 25 years. Pneumocystis carinii pneumonia remains a leading cause of death among HIV-infected patients and a significant cause of AIDS-related mortality and morbidity. This highlights the need for better understanding of the pathogenesis of the disease, and underscores the necessity of investigating new therapeutic strategies.

My research uses Pneumocystis pneumonia as one of the models to study the mechanisms of lung injury. I use a variety of immunology, imaging, and cell biolological techniques to study the role of alveolar macrophage phenotype during inflammatory lung diseases.

The specific goals of my research are to: 1) determine the functional changes in alveolar macrophages during inflammatory lung diseases, and 2) evaluate the feasibility of using specific macrophage phenotype subsets as adjunctive treatments to ameliorate inflammatory lung diseases.

Credentials

Education

1990-1995
M.D. Equivalency | Chongqing Medical University

1998
Master | Chongqing Medical University
Clinical Immunology

2006
PhD | School of Medicine and Dentistry, University of Rochester
Medical Microbiology and Immunology Graduate Program

Awards

2010
Junior Faculty Travel Grant
Sponsor: 2010 American Association of Immunologist, 97th AAI Annual Mtg
Location: Baltimore, MD

2009
Travel Award
Sponsor: 2009 American Thoracic Society International Conference
Location: San Diego, CA

2008
Travel Award
Sponsor: X International Workshops on Opportunistic Protists
Location: Boston, MA

2008
New York State Blavatnik Award for Young Scientists (Nominee)
Sponsor: University of Rochester School of Medicine and Dentistry

1998
Travel Award
Sponsor: The 22nd International Congress of Pediatrics
Location: Amsterdam, Holland

1990 - 1995
Dean's Scholarship for Excellent Academic Achievement(five-time recipient)
Location: Chongqing Medical University

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Publications

Journal Articles

2014
Bello-IrizarrySN; Wang J; Olsen K; Gigliotti F; Wright TW. "MyD88 signaling regulates both host defense and immnopathogenesis during Pneumocystis infection". J Immunol. 2014; : 282-92.

11/2012
Bello-Irizarry SN, Wang J, Olsen K, Gigliotti F, Wright TW. "The alveolar epithelial cell chemokine response to pneumocystis requires adaptor molecule MyD88 and interleukin-1 receptor but not toll-like receptor 2 or 4." Infection and immunity.. 2012 Nov 0; 80(11):3912-20. Epub 2012 Aug 27.

2011
Wang J, Wright TW, Gigliotti F. "Immune Modulation as Adjunctive Therapy for Pneumocystis pneumonia." Interdisciplinary perspectives on infectious diseases. 2011 2011:918038. Epub 2011 Aug 29.

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