Ian Robert Kleckner, Ph.D., M.P.H.

Contact Information

Research Labs

Ian Kleckner's Website

Visit Ian Kleckner's Website Lab Website

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 658
Rochester, NY 14642

Faculty Appointments

Assistant Professor - Department of Surgery , Cancer Control (SMD)
Assistant Professor - Department of Neuroscience (SMD) - Joint

Biography

Professional Background

My degrees in physics at the University of Rochester (BS, 2002-2006) and biophysics at The Ohio State University (PhD, 2006-2011) provided skills in writing, solving complex problems, computer programming, and the scientific method for experimental laboratory work. My undergraduate research used computational approaches to study subatomic particles, whereas my graduate work addressed the biochemistry and structural biology of how the flexibility of proteins contributes to their biological function. My post-doctoral fellowship at Northeastern University (2011-2015) – including two summer sabbaticals to the Laureate Institute for Brain Research – focused on investigating the role of the body in emotions using psychophysiology and brain fMRI. After my postdoctoral fellowship I began applying my basic scientific skills and my interests in exercise to an important public health problem: cancer. I was particularly drawn to work at the University of Rochester Cancer Control Unit (2015-Current) because of their successful research program using exercise to reduce side-effects from cancer and its treatment.

Research

Dr. Kleckner's work aims to ameliorate the symptoms of cancer and its treatment by leveraging an understanding how the brain processes the state of the body. He uses methods from psychophysiology (measuring heartbeats, skin conductance), brain imaging (fMRI), and exercise science with computational approaches honed from his background from physics and biophysics.

Credentials

Education

2006
BS | University of Rochester
Physics

2009
MS | Ohio State University
Biophysics

2011
PhD | Ohio State University
Biophysics

2015
Postdoctoral Fellowship | Northeastern University
Psychology and Neuroscience

2015
Postdoctoral Sabbatical | Laureate Institute for Brain Research
Neuroimaging

MPH | University of Rochester Medical Center
Public Health

Awards

2018 - 2023
K07 Cancer Control Fellowship: The Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy... (K07CA221931)
Sponsor: National Cancer Institute (NCI)
Location: University of Rochester Medical Center

2018
Second Place Oral Presentation
Sponsor: Department of Surgery, University of Rochester
Location: Rochester, NY, USA.

2018
Fellow of the Transdisciplinary Research in Energetics and Cancer Research Education Program (TREC Workshop)
Sponsor: National Cancer Institute and the Yale School of Public Health
Location: Westbrook, CT, USA

2018
Emeritus Award for Excellence in MPH Thesis
Sponsor: University of Rochester Department of Public Health Sciences
Location: Rochester, NY, USA

2017
Best Poster Finalist
Sponsor: Neuropathic Pain Special Interest Group (NeuPSIG) Intl Mtg
Location: Gothenburg, Sweden

2017
Fellow of the MGH Workshop on Research Methods in Supportive Oncology
Sponsor: Massachusetts General Hospital and National Cancer Institute
Location: Boston, MA

2016
Best of ASCO
Sponsor: American Society for Clinical Oncology
Location: Chicago, IL, USA

2016
Pain & Symptom Management Special Merit Award
Sponsor: Conquer Cancer Foundation of ASCO
Location: Chicago, IL, USA

2016
Fellow of the SBM Mock Grant Review Workshop
Sponsor: Society for Behavioral Medicine
Location: Washington, DC

2012 - 2015
F32 NRSA Post-doctoral Fellowship: The Role Of Interoceptive Awareness In Affect And Related Mental Faculties (5F32MH096533)
Sponsor: National Institutes of Mental Health (NIMH)
Location: Northeastern University

2011
Selected for student talk
Sponsor: Ohio State University
Location: 5th OSU Molecular Life Science Interdisciplinary Graduate Prog

2011
Outstanding student presentation
Sponsor: Ohio State University
Location: 5th OSU Molecular Life Science Interdisciplinary Graduate Prog

2011
Best student presentation of 2010/2011 academic year
Sponsor: Ohio State University
Location: Ohio State University Biophysics Seminar

2010
Burrell Memorial travel grant
Sponsor: Ohio State University
Location: Biochemistry Department

2010
Outstanding poster award
Sponsor: Gordon Research Conference
Location: Gordon Research Conference on Biopolymers

2010
First place oral presentation in Math and Physics Sciences
Sponsor: Ohio State University
Location: 24th Hayes Graduate Research Forum

2010
Plenary student talk
Sponsor: Ohio State University
Location: 4th OSU Molecular Life Science Interdisciplinary Graduate Prog

2009
Outstanding poster award
Sponsor: Ohio State University
Location: 3rd OSU Molecular Life Science Interdisciplinary Graduate Prog

2009
Experimental NMR Conference (ENC) student travel grant
Sponsor: Experimental NMR Conference

2009
Burrell Memorial travel grant
Sponsor: Ohio State University
Location: Biochemistry Department

2008
Burrell Memorial travel grant
Sponsor: Ohio State University
Location: Biochemistry Department

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Clinical Trials

The Effects of Exercise and Nutrition Interventions on Chemotherapy-induced Peripheral Neuropathy and Interoceptive Brain Circuitry

Lead Researcher: Ian Robert Kleckner

Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and severe side-effect of taxane chemotherapy, often used to treat breast cancer. Unfortunately there are very limited treatments for CIPN. This is a phase II randomized controlled trial to test the preliminary efficacy of exercise vs. nutrition education on CIPN, to systematically investigate the potential roles of inflammation and interoception, and to obtain data with a more accurate effect size to inform a future study.

View Study Details

Publications

Journal Articles

6/30/2021
Kleckner IR, Jusko TA, Culakova E, Chung K, Kleckner AS, Asare M, Inglis JE, Loh KP, Peppone LJ, Miller J, Melnik M, Kasbari S, Ossip D, Mustian KM. "Longitudinal study of inflammatory, behavioral, clinical, and psychosocial risk factors for chemotherapy-induced peripheral neuropathy." Breast cancer research and treatment.. 2021 Jun 30; Epub 2021 Jun 30.

3/3/2021
Loh KP, Sanapala C, Di Giovanni G, Klepin HD, Janelsins M, Schnall R, Culakova E, Vertino P, Susiarjo M, Mendler JH, Liesveld JL, Lin PJ, Dunne RF, Kleckner I, Mustian K, Mohile SG. "Developing and adapting a mobile health exercise intervention for older patients with myeloid neoplasms: A qualitative study." Journal of geriatric oncology.. 2021 Mar 3; Epub 2021 Mar 03.

2021
Omran M, Belcher EK, Mohile NA, Kesler SR, Janelsins MC, Hohmann AG, Kleckner IR. "Review of the Role of the Brain in Chemotherapy-Induced Peripheral Neuropathy." . 2021 8:693133. Epub 2021 Jun 11.

Books & Chapters

2018
Chapter Title: Fatigue
Book Title: Handbook of Cancer Survivorship
Author List: Mustian KM; Lin P; Kleckner IR; Loh M
Published By: Springer 2018

2015
Chapter Title: Emotional experience
Book Title: Brain Mapping: An Encyclopedic Reference
Author List: Satpute AB; Wilson-Mendenhall CD; Kleckner IR; Barrett, LF
Edited By: Toga A & Lieberman M
Published By: Academic Press 2015 in London

2014
Chapter Title: An approach to mapping the neurophysiological state of the body to affective experience
Book Title: The Psychological Construction of Emotion
Author List: Kleckner IR & Quigley KS
Edited By: Barrett LF & Russel JA
Published By: Guilford 2014 in New York

VIEW ALL PUBLICATIONS