Clement L. Ren, M.D.

Clement L. Ren, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 667
Rochester, NY 14642

Office: (585) 275-2464
Fax: (585) 275-8706

Professional Bio

Dr. Ren received his AB in Biophysics from the University of California at Berkeley and his MD from the University of Chicago. He completed a pediatric residency and fellowship in allergy/immunology at Harvard Medical School, Children's Hospital in Boston and a second fellowship in pediatric pulmonology at St. Christopher's Hospital for Children in Philadelphia. He arrived in Rochester in 2001 to serve as the Chief of Pediatric Pulmonology and Co-Director Cystic Fibrosis Center and since been named, Director, Golisano Children's Hospital Outpatient Child Health Services.

Dr. Ren has served for over ten years on the Editorial Board, Pediatric Allergy, Asthma, and Immunology. He is the co-editor of PREP Pulmonology and deputy editor for ACCP SEEK Pediatrics. In addition, has been an ad hoc reviewer for Pediatric Pulmonology, Chest, Pediatric Transplantation, American Journal of Respiratory and Critical Care Medicine, Annals of Allergy, Asthma, and Immunology, Journal of Pediatrics, Pediatrics, and Pediatric Research.

National Leadership Positions

Dr. Ren is active in the CF Foundation, American Thoracic Society, and American College of Chest Physicians having held key leadership positions and is an active participant in their annual conferences. Currently he serves nationally in the following capacities:

2011- Co-Chair, CF Foundation Newborn Screening Quality Improvement Consortium
2011 - Cystic Fibrosis Foundation Quality Improvement RFA Review Committee
2010- EPIC Scientific Advisory Committee
2006- Data Safety Monitoring Board, Cystic Fibrosis Foundation
2004- Publications Committee; The Early Pseudomonas Infection Control (EPIC) Study
2004- Planning Committee, Pediatric Assembly of the American Thoracic Society
2001- North American Scientific Advisory Group, Epidemiologic Study of Cystic Fibrosis (ESCF)

Regional Leadership Positions

2008-12 Co-Chair, Rochester Regional Breath of Hope Asthma Initiative

Research Bio

Dr. Ren's research applies novel methods of pulmonary function testing in infants and young children to clinical and translational studies of pediatric respiratory disease.
Our current areas of disease focus are cystic fibrosis and premature lung
disease and Prematurity and Respiratory Outcomes Program (PROP).

Dr. Ren is the pulmonary PI and the co-chair of the Pulmonary Working Group for PROP. PROP is an NIH funded multicenter program whose aim is to promote collaborative, innovative research to identify mechanisms and associated functional and molecular biomarkers of respiratory disease risk of premature infants ready for discharge from the neonatal intensive care unit (NICU). As part of the PROP, he assist in conducting a longitudinal study of respiratory function in the first year of life utilizing non-invasive respiratory testing (including RIP) and performing infant PFTs using the raised volume rapidthoracoabdominal compression technique.

Cystic Fibrosis

Epidemiologic Study of Cystic Fibrosis (ESCF)

The ESCF was a prospective observational study of CF patients in North America. Data were collected from 1994-2005, and analyses are still ongoing. Using ESCF data, we have studied the effect of inhaled corticosteroid therapy on lung function, the impact of methicillin resistant S. aureus infection on lung function, and the relationship between infant care patterns and outcomes. We recently used ESCF data to demonstrate that wheezing in early childhood is associated with lower lung function in children with CF.

Early Pseudomonas Infection Control Observational Study (EPIC)

EPIC is a longitudinal cohort study of young CF patients whose primary goal is to identify risk factors for the acquisition of Pseudomonas aeruginosa (Pa). Secondary objectives include better definition of outcomes associated with Pa infection and the impact of other organisms on clinical outcomes.

CF Clinical Trials

As a member of the CF Foundation Therapeutics Development Network the Pediatric Pulmonary Division is involved in a number of clinical trials. Further information regarding clinical trials can be found at the Division of Pediatric Pulmonology website:

Advanced Lung Function Testing

Multiple breath washout (MBW) equipment was recently added to our Pediatric Pulmonary Function Laboratory. MBW is a noninvasive method to assess ventilation inhomogeneity, a feature of many pediatric lung diseases, such as CF. Our group is presently developing pilot projects to apply MBW to the study of CF and preterm lung disease.

Awards & Honors (National)

Cystic Fibrosis Foundation Quality Care Award | Cystic Fibrosis Foundation 2013
Consumers' Research Council of America's Top Pediatricians 2011
Castle Connolly Top Doctor 2010 - Present
Cystic Fibrosis Foundation Quality Care Award | Cystic Fibrosis Foundation 2008
Marion Merrill Dow Scholar in Allergy Award | Marion Merrill Dow 1992
American Liver Foundation Student Research Fellowship | American Liver Foundation 1986
Achievement Rewards for College Scientists | ARCS Foundation 1983

Awards & Honors (Local)

URMC Board Excellence Award -- CF Team 2014
Ruth Lawrence Faculty Services Award for Clinical Services | University of Rochester Department of Pediatrics 2013
George Washington Goler Professor of Pediatrics, University of Rochester 2008 - 2011
AAMC Humanism in Medicine Nominee | Association of American Medical Colleges 2004
Award for Outstanding Teaching | Class of 1999 | State University of New York at Stony Brook 1999
Resident Teaching Award | Department of Pediatrics | State University of New York at Stony Brook 1997
Children's Hospital Farley Fund Research Award | Children's Hospital Farley Fund | Children's Hospital 1992
Associated Western Universities Student Research Internship 1982

Recent Journal Articles

Showing the 5 most recent journal articles. 39 available »

2015 Sep
Rosenfeld M, VanDevanter DR, Ren CL, Elkin EP, Pasta DJ, Konstan MW, Morgan WJ, . "Decline in lung function does not predict future decline in lung function in cystic fibrosis patients." Pediatric pulmonology. 2015 Sep; 50(9):856-62. Epub 2015 Jun 18.
2015 Aug
Cogen J, Emerson J, Sanders DB, Ren C, Schechter MS, Gibson RL, Morgan W, Rosenfeld M, . "Risk factors for lung function decline in a large cohort of young cystic fibrosis patients." Pediatric pulmonology. 2015 Aug; 50(8):763-70. Epub 2015 Jun 09.
2015 Aug
Kay DM, Langfelder-Schwind E, DeCelie-Germana J, Sharp JK, Maloney B, Tavakoli NP, Saavedra-Matiz CA, Krein LM, Caggana M, Kier C, . "Utility of a very high IRT/No mutation referral category in cystic fibrosis newborn screening." Pediatric pulmonology. 2015 Aug; 50(8):771-80. Epub 2015 Jun 22.
2015 Aug
Sanders DB, Emerson J, Ren CL, Schechter MS, Gibson RL, Morgan W, Rosenfeld M, . "Early Childhood Risk Factors for Decreased FEV1 at Age Six to Seven Years in Young Children with Cystic Fibrosis." Annals of the American Thoracic Society. 2015 Aug; 12(8):1170-6.
2015 Jun
Ren CL, Fink AK, Petren K, Borowitz DS, McColley SA, Sanders DB, Rosenfeld M, Marshall BC. "Outcomes of infants with indeterminate diagnosis detected by cystic fibrosis newborn screening." Pediatrics. 2015 Jun; 135(6):e1386-92. Epub 2015 May 11.

Current Appointments

Professor (Part-Time) - Department of Pediatrics, Pulmonary/Allergy (SMD) - Primary


Allergy and Immunology - American Board of Allergy and Immunology
Pediatrics - American Board of Pediatrics
Pediatric Pulmonology - American Board of Pediatrics


MD | Medicine | University of Chicago, Pritzker Medical School1987
AB | Biophysics | University of California - Berkeley1983

Post-Doctoral Training & Residency

Pediatric Pulmonology Fellowship, St. Christopher's Hospital for Children, Philadelphia, PA 1996
Pediatric Immunology/Allergy Fellowship, Children's Hospital, Boston, MA 1993
Residency in Pediatrics, Children's Hospital, Boston, MA 1990