Research Bio
Research interest includes the following:
1) Control of the brain microenvironment (Blood-brain barrier, choroid plexus and cerebrospinal fluid).
2) Metals in health and disease.
3) Aging and neurodegenerative diseases (e.g. Alzheimer's disease).
2009 Mar
Guo H, Singh I, Wang Y, Deane R, Barrett T, Fernández JA, Chow N, Griffin JH, Zlokovic BV. "Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity." The European journal of neuroscience. 2009 Mar; 29(6):1119-30. |
2009 Feb
Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV. "SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells." Nature cell biology. 2009 Feb; 11(2):143-53. Epub 2008 Dec 21. |
2009 Jan
Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV. "Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier." Journal of cerebral blood flow and metabolism : official journal of
the International Society of Cerebral Blood Flow and Metabolism. 2009 Jan; 29(1):25-33. Epub 2008 Oct 08. |
2008 Apr
Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV. "ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration." Nature neuroscience. 2008 Apr; 11(4):420-2. Epub 2008 Mar 16. |
2008
Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. "apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain." The Journal of clinical investigation.. 2008 118(12):4002-13. Epub 2008 Nov 13. |
