Rashid Deane, B.Sc., Ph.D.

Rashid Deane, B.Sc., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 670
Rochester, NY 14642

Office: (585) 273-5377

Journal Articles

Showing all 59 journal articles available.

2015 Aug 5
Lee H, Xie L, Yu M, Kang H, Feng T, Deane R, Logan J, Nedergaard M, Benveniste H. "The Effect of Body Posture on Brain Glymphatic Transport." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 Aug 5; 35(31):11034-44.
2015 Jan 14
Plog BA, Dashnaw ML, Hitomi E, Peng W, Liao Y, Lou N, Deane R, Nedergaard M. "Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 Jan 14; 35(2):518-26.
2015
Lundgaard I, Li B, Xie L, Kang H, Sanggaard S, Haswell JD, Sun W, Goldman S, Blekot S, Nielsen M, Takano T, Deane R, Nedergaard M. "Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism." Nature communications. 2015 6:6807. Epub 2015 Apr 23.
2014 Jul 1
Petraglia AL, Plog BA, Dayawansa S, Chen M, Dashnaw ML, Czerniecka K, Walker CT, Viterise T, Hyrien O, Iliff JJ, Deane R, Nedergaard M, Huang JH. "The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy." Journal of neurotrauma. 2014 Jul 1; 31(13):1211-24. Epub 2014 Jun 12.
2014
Iliff JJ, Chen MJ, Plog BA, Zeppenfeld DM, Soltero M, Yang L, Singh I, Deane R, Nedergaard M. "Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 34(49):16180-93.
2014
Kress BT, Iliff JJ, Xia M, Wang M, Wei H, Zeppenfeld D, Xie L, Kang H, Xu Q, Liew J, Plog BA, Ding F, Deane R, Nedergaard M. "Impairment of paravascular clearance pathways in the aging brain." Annals of neurology. 2014 76(6):845-61. Epub 2014 Sep 26.
2014
Petraglia AL, Plog BA, Dayawansa S, Dashnaw ML, Czerniecka K, Walker CT, Chen M, Hyrien O, Iliff JJ, Deane R, Huang JH, Nedergaard M. "The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy." Surgical neurology international. 2014 5:184. Epub 2014 Dec 23.
2013 Nov 13
Iliff JJ, Wang M, Zeppenfeld DM, Venkataraman A, Plog BA, Liao Y, Deane R, Nedergaard M. "Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Nov 13; 33(46):18190-9.
2013 Oct 18
Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O'Donnell J, Christensen DJ, Nicholson C, Iliff JJ, Takano T, Deane R, Nedergaard M. "Sleep drives metabolite clearance from the adult brain." Science. 2013 Oct 18; 342(6156):373-7.
2013 Sep 3
Singh I, Sagare AP, Coma M, Perlmutter D, Gelein R, Bell RD, Deane RJ, Zhong E, Parisi M, Ciszewski J, Kasper RT, Deane R. "Low levels of copper disrupt brain amyloid-? homeostasis by altering its production and clearance." Proceedings of the National Academy of Sciences of the United States of America. 2013 Sep 3; 110(36):14771-6. Epub 2013 Aug 19.
2013
Rangroo Thrane V, Thrane AS, Plog BA, Thiyagarajan M, Iliff JJ, Deane R, Nagelhus EA, Nedergaard M. "Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain." Scientific reports. 2013 3:2582.
2012 Aug 15
Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M. "A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid ?." Science translational medicine. 2012 Aug 15; 4(147):147ra111.
2012 May 24
Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. "Apolipoprotein E controls cerebrovascular integrity via cyclophilin A." Nature. 2012 May 24; 485(7399):512-6. Epub 2012 May 16.
2012 Apr
Deane R, Singh I, Sagare AP, Bell RD, Ross NT, Larue B, Love R, Perry S, Paquette N, Deane RJ, Meenakshisundaram T, Zarcone T, Fritz G, Friedman AE, Miller BL, Zlokovic BV. "A multimodal RAGE-specific inhibitor reduces amyloid ?-mediated brain disorder in a mouse model of Alzheimer disease." The Journal of clinical investigation. 2012 Apr; 122(4):1377-92. Epub 2012 Mar 12.
2011 Feb 10
Polesskaya O, Silva J, Sanfilippo C, Desrosiers T, Sun A, Shen J, Feng C, Polesskiy A, Deane R, Zlokovic B, Kasischke K, Dewhurst S. "Methamphetamine causes sustained depression in cerebral blood flow." Brain research. 2011 Feb 10; 1373:91-100. Epub 2010 Dec 13.
2011
Sagare AP, Deane R, Zetterberg H, Wallin A, Blennow K, Zlokovic BV. "Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-? is an early biomarker for mild cognitive impairment preceding Alzheimer's disease." Journal of Alzheimer's disease : JAD. 2011 24(1):25-34.
2010 Nov 4
Bell RD, Winkler EA, Sagare AP, Singh I, Larue B, Deane R, Zlokovic BV. "Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging." Neuron. 2010 Nov 4; 68(3):409-27.
2010 Jun 10
Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV. "Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor." Blood. 2010 Jun 10; 115(23):4963-72. Epub 2010 Mar 26.
2010 Mar 4
Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC. "Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice." Brain research. 2010 Mar 4; 1317:218-26. Epub 2010 Jan 04.
2010
Zlokovic BV, Deane R, Sagare AP, Bell RD, Winkler EA. "Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid ?-peptide elimination from the brain." Journal of neurochemistry. 2010 115(5):1077-89. Epub 2010 Oct 05.
2009 Nov
Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV. "Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells." The Journal of clinical investigation. 2009 Nov; 119(11):3437-49. Epub 2009 Oct 19.
2009 Mar
Deane R, Bell RD, Sagare A, Zlokovic BV. "Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease." CNS & neurological disorders drug targets. 2009 Mar; 8(1):16-30.
2009 Mar
Guo H, Singh I, Wang Y, Deane R, Barrett T, Fernández JA, Chow N, Griffin JH, Zlokovic BV. "Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity." The European journal of neuroscience. 2009 Mar; 29(6):1119-30.
2009 Feb
Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV. "SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells." Nature cell biology. 2009 Feb; 11(2):143-53. Epub 2008 Dec 21.
2009 Jan
Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV. "Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2009 Jan; 29(1):25-33. Epub 2008 Oct 08.
2008 Apr
Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV. "ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration." Nature neuroscience. 2008 Apr; 11(4):420-2. Epub 2008 Mar 16.
2008
Deane R, Sagare A, Zlokovic BV. "The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease." Current pharmaceutical design. 2008 14(16):1601-5.
2008
Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. "apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain." The Journal of clinical investigation. 2008 118(12):4002-13. Epub 2008 Nov 13.
2007 Sep
Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV. "Clearance of amyloid-beta by circulating lipoprotein receptors." Nature medicine. 2007 Sep; 13(9):1029-31. Epub 2007 Aug 12.
2007 May
Bell RD, Sagare AP, Friedman AE, Bedi GS, Holtzman DM, Deane R, Zlokovic BV. "Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2007 May; 27(5):909-18. Epub 2006 Nov 01.
2007 Apr
Deane R, Zlokovic BV. "Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease." Current Alzheimer research. 2007 Apr; 4(2):191-7.
2007 Feb
Takano T, Han X, Deane R, Zlokovic B, Nedergaard M. "Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease." Annals of the New York Academy of Sciences. 2007 Feb; 1097:40-50.
2007 Jan 16
Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV. "Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype." Proceedings of the National Academy of Sciences of the United States of America. 2007 Jan 16; 104(3):823-8. Epub 2007 Jan 10.
2007
Deane, R.; Zlokovic, B.V. "Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease". Current Alzheimer's Research. 2007; 4: 191-197.
2007
Bell, RD; Sagare A; Friedman AE; Bedi G; Holtzman; Deane R; Zlokovic BV. "Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J." J Cerebral Blood flow and Metabolism. 2007; 27: 909-918.
2007
Deane, R; Zlokovic, BV. "Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease". Current Alzheimer's Research. 2007; 4: 191-197.
2006 Nov
Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. "Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage." Nature medicine. 2006 Nov; 12(11):1278-85. Epub 2006 Oct 29.
2006
Kassem, N. A.; Deane, R.; Segal, M. B.; Preston, J. E.;. "Role of transthyretin in thyroxine transfer from cerebrospinal fluid to brain and choroid plexus". American Journal of Physiology - Regulatory Integrative & Comparative Physiology. 2006; 291(5): R1310-R1315.
2005 Nov
Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. "P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model." The Journal of clinical investigation. 2005 Nov; 115(11):3285-90. Epub 2005 Oct 20.
2005 Sep
Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV. "Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease." Nature medicine. 2005 Sep; 11(9):959-65. Epub 2005 Aug 14.
2005 Jan
Zlokovic BV, Deane R, Sallstrom J, Chow N, Miano JM. "Neurovascular pathways and Alzheimer amyloid beta-peptide." Brain pathology. 2005 Jan; 15(1):78-83.
2005
Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, Wu Z, Holtzman DM, Zlokovic BV. "IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 25(50):11495-503.
2004 Nov
Deane R, Wu Z, Zlokovic BV. "RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier." Stroke; a journal of cerebral circulation. 2004 Nov; 35(11 Suppl 1):2628-31. Epub 2004 Sep 30.
2004 Sep 30
LaRue B, Hogg E, Sagare A, Jovanovic S, Maness L, Maurer C, Deane R, Zlokovic BV. "Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice." Journal of neuroscience methods. 2004 Sep 30; 138(1-2):233-42.
2004 Aug 5
Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, Zlokovic BV. "LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms." Neuron. 2004 Aug 5; 43(3):333-44.
2004 May 7
Davis J, Xu F, Deane R, Romanov G, Previti ML, Zeigler K, Zlokovic BV, Van Nostrand WE. "Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor." The Journal of biological chemistry. 2004 May 7; 279(19):20296-306. Epub 2004 Feb 25.
2004 Feb
Deane R, Zheng W, Zlokovic BV. "Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain." Journal of neurochemistry. 2004 Feb; 88(4):813-20.
2003 Jul
Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B. "RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain." Nature medicine. 2003 Jul; 9(7):907-13.
2003
Zheng, W.; Deane, R.; Redzic, Z.; Preston, J. E.; Segal, M. B.;. "Transport of L-125Ithyroxine by in situ perfused ovine choroid plexus: inhibition by lead exposure". Journal of Toxicology & Environmental Health Part A. 2003; 66(5): 435-451.
1993
Bradbury MW, Deane R. "Permeability of the blood-brain barrier to lead." Neurotoxicology. 1993 14(2-3):131-6.
1990 Mar
Deane R, Bradbury MW. "Transport of lead-203 at the blood-brain barrier during short cerebrovascular perfusion with saline in the rat." Journal of neurochemistry. 1990 Mar; 54(3):905-14.
1988
Bradbury MW, Deane R. "Brain endothelium and interstitium as sites for effects of lead." Annals of the New York Academy of Sciences. 1988 529:1-8.
1987 May
Jones HC, Deane R, Bucknall RM. "Developmental changes in cerebrospinal fluid pressure and resistance to absorption in rats." Brain research. 1987 May; 430(1):23-30.
1986
Deane, R.; Park, S. H.; Bradbury, M. W.;. "Effect of intravenous ferric or aluminum chloride on the uptake of 203Pb into brain and other soft tissues of rats". Journal of Pharmacology & Experimental Therapeutics. 1986; 239(2): 548-553.
1986
Bradbury MW, Deane R. "Rate of uptake of lead-203 into brain and other soft tissues of the rat at constant radiotracer levels in plasma." Annals of the New York Academy of Sciences. 1986 481:142-60.
1979
Deane, R.; Segal, M. B.;. "The effect of vascular perfusion of the choroid plexus on the secretion of cerebrospinal fluid proceedings". Journal of Physiology (London). 1979; 293: 18P-19P.
1979
Deane, R.; Segal, M. B.;. "The effect of phloridzin, phloretin and theophylline on the transport of sugars by the choroid plexus proceedings". Journal of Physiology (London). 1979; 287: 35P-36P.
1978
Deane, R.; Segal, M. B.;. "Effect of vascular perfusion on the transfer of sugars across the choroid plexus of the sheep proceedings". Journal of Physiology (London). 1978; 285: 57P.
1976
Deane, R.; Segal, M. B.;. "The sodium-dependent absorption of sugars across the coroid plexus of the sheep proceedings". Journal of Physiology (London). 1976; 263(2): 274P-275P.

Books

1990
Deane, R.; Bradbury, M. W. B.. "Lead and the Brain". Pathophysiology of the blood-brain barrier : long term consequences of barrier d. Johansson, B. B.; Owman, C.; Widner, H.. New York: Elsevier, 1990. 279-291
1987
Deane, R.; Bradbury, M. W. B.. "Is Pulsation Important for the Brain?". Peptide and amino acid transport mechanisms in the central nervous system. Rakic, L.. : Macmillan, 1987. 305-317
1985
Deane, R.; Segal, M. W.. "Why is the Concentration of Glucose in CSF Less Than in Plasma?". Carrier mediated transport of solutes from blood to tissue. Yudilevich, D.L.; Mann, G.E.. New York: Longman, 1985. 303-306