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Andrea Sant, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-9798

Research Labs

Lab: (585) 273-5385

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Faculty Appointments

Biography

Research

Our research seeks to understand the elements in vivo that dictate the selective specificities in CD4 T cells during protective immune responses, the competitive events that shape selective recognition of foreign and pathogenic organisms in vivo. We seek to identify links between the specificity and function of CD4 T cells. A major interest in our laboratory is the role of CD4 T cells in immunity to influenza infection and vaccination, using both animal models and human studies. We have developed the technology to comprehensively evaluate the antigen specificity and the magnitude of the CD4 T cell responses using completely unbiased methodology and have most recently focused on the role and specificity of CD4 T cells in promoting neutralizing antibody responses to influenza infection and vaccination both in human subjects and animal models.

To address these research topics, our lab utilizes many sophisticated tools and approaches, such as novel, recombinant fluorescent reporter viruses, multiparameter flow cytometry, imaging, gene expression and multiple animal models of influenza infection and vaccination. To complement the mechanistic studies we are performing in animal models, we are also assessing cellular responses from human samples. To this end, insights gained from our studies from human vaccine trials aim to dissect correlates of immune protection and reveal possible links between antigen specificity and effector function of CD4 T cells. Because our work is highly interdisciplinary, we currently have exciting intra and inter-center collaborations with virologists and infectious disease specialists, providing a wide range of expertise and clinically relevant, research-focused training opportunities.

Credentials

Education

1977
BA | SUNY College at Oswego
Chemistry and Biology

1985
PhD | Washington University
Immunology

Awards

2013
AAI Awards Committee

2013
Section Editor
Sponsor: Journal of Immunology

2013
Ad Hoc reviewer
Sponsor: CMI-A study Section

2012
Ad Hoc reviewer
Sponsor: CMI-B Study Section

2012
Ad Hoc reviewer
Sponsor: NIH VMD Study Section

2005 - 2007
Chair
Sponsor: Cellular and Molecular Immunology (CMI-B) Study Section

2003 - 2005
Ad Hoc reviewer
Sponsor: NIH/NIAID Immunobiology Study Section

2002 - Present
Elected to Faculty of 1000 in Immunology

2001
Ad Hoc reviewer
Sponsor: National Institutes of Health Study Sections

2000
Breast Cancer Study Section
Sponsor: Department of Army

1999
Ad Hoc reviewer
Sponsor: National Institutes of Health Study Sections

1999
Study Section
Sponsor: Department of Defense

1998
Breast Cancer Study Section
Sponsor: Department of Army

1997
Study Section
Sponsor: Department of Defense

1996 - 1999
Study Section Co-Chair
Sponsor: American Heart Association

1996 - 1997
Chair
Sponsor: Arthritis Foundation Study Section (Co Chair 1996)

1994 - 1996
Ad Hoc reviewer
Sponsor: American Cancer Society Study Section

1994 - 1995
Ad Hoc reviewer
Sponsor: National Institutes of Health Study Sections

1989 - 1990
Zeisler Junior Faculty Scholars Award
Location: $25,000

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Publications

Journal Articles

4/18/2018
DiPiazza A, Laniewski N, Rattan A, Topham DJ, Miller J, Sant AJ. "CD4 T cell epitope specificity and cytokine potential are preserved as cells transition from the lung vasculature to lung tissue following influenza infection." Journal of virology.. 2018 Apr 18; Epub 2018 Apr 18.

4/2/2018
Sant AJ, Richards KA, Nayak J. "Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus." Current opinion in immunology.. 2018 Apr 2; 53:13-21. Epub 2018 Apr 02.

2018
Richards KA, DiPiazza AT, Rattan A, Knowlden ZAG, Yang H, Sant AJ. "Diverse Epitope Specificity, Immunodominance Hierarchy, and Functional Avidity of Effector CD4 T Cells Established During Priming Is Maintained in Lung After Influenza A Virus Infection." Frontiers in immunology.. 2018 9:655. Epub 2018 Apr 06.

Books & Chapters

2006
Chapter Title: The Mechanics of Class II Processing: Establishment of a Class II Hierarchy
Book Title: Immunodominance: The Choice of the Immune System
Author List: Drake J; Sant AJ
Edited By: J Frelinger
Published By: Wiley-VCH2006

1994
Chapter Title: Intracellular events regulating MHC Class II restricted antigen presentation
Book Title: Antigen Processing and Presentation
Author List: Sant, AJ, Chervonsky, A, Dykhuizen, M, Katz, JF, Loss, GE, Stebbins, C, and LJ Tan
Edited By: S Pierce and R Humphreys
Published By: Academic Press1994

1988
Chapter Title: DNA-mediated gene transfer as a tool for analyzing la structure-function relationships and antigen presentation
Book Title: Antigen Presenting Cells: Diversity, Differentiation and Regulation
Author List: Braunstein, NS, Ronchese, F, Sant, AJ, Schwartz, RH, Lechler, RI, and Germain, RN
Published By: Alan R. Liss, Inc.1988

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