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Andrea Sant, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-9798

Research Labs

Lab: (585) 273-5385

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Biography

Research

The defining feature of the immune system is its ability to distinguish self from non-self. The major component of the immune system responsible for this self / non-self discrimination is the diverse repertoire of antigen-specific T lymphocytes. T cell receptors can only recognize antigens derived from pathogens or transformed cells if these antigens in the derived peptide fragments of pathogenic protieins combine with Major Histocompatibility Complex (MHC) molecules.

The research in my laboratory centers around the molecular events that regulate MHC class II-restricted antigen presentation and CD4 T cell activation in vivo. We are particularly focussed on making connections between the mechanisms involved in intracellular peptide acquisition by class II molecules and use of this insight to rationally enhance human vaccine design. We seek to understand the elements in vivo that dictate the selective specificities in CD4 T cells during protective immune responses, and the competitive events that shape selective recognition of foreign and pathogenic organisms and proteins in vivo. We are also focused on understanding the regulatory events in vivo that shape the specificity and function of immune responses.

Our research interests include understanding the relationship between the biochemistry of peptide:MHC class II complexes and specificity of CD4 T cells during both protein and peptide vaccination and how this link can be harnessed to shape CD4 T cell specificity. A second major interest in our laboratory is the role of CD4 T cells in immunity to influenza infection and vaccination, using both animal models and human studies. We are particularly interested in the role that memory CD4 T cell play in protective immunity to potentially pandemic influenza strains.

Credentials

Faculty Appointments

Education

1977
BA | SUNY College at Oswego
Chemistry and Biology

1985
PhD | Washington University
Immunology

Awards

2013
AAI Awards Committee

2013
Section Editor
Sponsor: Journal of Immunology

2013
Ad Hoc reviewer
Sponsor: CMI-A study Section

2012
Ad Hoc reviewer
Sponsor: CMI-B Study Section

2012
Ad Hoc reviewer
Sponsor: NIH VMD Study Section

2005 - 2007
Chair
Sponsor: Cellular and Molecular Immunology (CMI-B) Study Section

2003 - 2005
Ad Hoc reviewer
Sponsor: NIH/NIAID Immunobiology Study Section

2002 - Present
Elected to Faculty of 1000 in Immunology

2001
Ad Hoc reviewer
Sponsor: National Institutes of Health Study Sections

2000
Breast Cancer Study Section
Sponsor: Department of Army

1999
Ad Hoc reviewer
Sponsor: National Institutes of Health Study Sections

1999
Study Section
Sponsor: Department of Defense

1998
Breast Cancer Study Section
Sponsor: Department of Army

1997
Study Section
Sponsor: Department of Defense

1996 - 1999
Study Section Co-Chair
Sponsor: American Heart Association

1996 - 1997
Chair
Sponsor: Arthritis Foundation Study Section (Co Chair 1996)

1994 - 1996
Ad Hoc reviewer
Sponsor: American Cancer Society Study Section

1994 - 1995
Ad Hoc reviewer
Sponsor: National Institutes of Health Study Sections

1989 - 1990
Zeisler Junior Faculty Scholars Award
Location: $25,000

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Publications

Journal Articles

9/7/2017
DiPiazza A, Nogales A, Poulton N, Wilson PC, Martínez-Sobrido L, Sant AJ. "Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo." Scientific reports.. 2017 Sep 7; 7(1):10857. Epub 2017 Sep 07.

3/2017
DiPiazza A, Richards K, Poulton N, Sant AJ. "Avian and Human Seasonal Influenza Hemagglutinin Proteins Elicit CD4 T Cell Responses That Are Comparable in Epitope Abundance and Diversity." Clinical and vaccine immunology : CVI.. 2017 Mar 0; 24(3)Epub 2017 Mar 06.

9/1/2016
DiPiazza A, Richards K, Batarse F, Lockard L, Zeng H, García-Sastre A, Albrecht RA, Sant AJ. "Flow Cytometric and Cytokine ELISpot Approaches To Characterize the Cell-Mediated Immune Response in Ferrets following Influenza Virus Infection." Journal of virology.. 2016 Sep 1; 90(17):7991-8004. Epub 2016 Aug 12.

Books & Chapters

2006
Chapter Title: The Mechanics of Class II Processing: Establishment of a Class II Hierarchy
Book Title: Immunodominance: The Choice of the Immune System
Author List: Drake J; Sant AJ
Edited By: J Frelinger
Published By: Wiley-VCH2006

1994
Chapter Title: Intracellular events regulating MHC Class II restricted antigen presentation
Book Title: Antigen Processing and Presentation
Author List: Sant, AJ, Chervonsky, A, Dykhuizen, M, Katz, JF, Loss, GE, Stebbins, C, and LJ Tan
Edited By: S Pierce and R Humphreys
Published By: Academic Press1994

1988
Chapter Title: DNA-mediated gene transfer as a tool for analyzing la structure-function relationships and antigen presentation
Book Title: Antigen Presenting Cells: Diversity, Differentiation and Regulation
Author List: Braunstein, NS, Ronchese, F, Sant, AJ, Schwartz, RH, Lechler, RI, and Germain, RN
Published By: Alan R. Liss, Inc.1988

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