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Ollivier Hyrien, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 630
Rochester, NY 14642

Office: (585) 275-5303

Journal Articles

Showing all 42 journal articles available.

2012 Mar 1
Zhang H, Travis LB, Chen R, Hyrien O, Milano MT, Newlands SD, Chen Y. "Impact of radiotherapy on laryngeal cancer survival: a population-based study of 13,808 US patients." Cancer. 2012 Mar 1; 118(5):1276-87. Epub 2011 Jul 19.
2011 Aug 1
Chen Y, Pandya KJ, Hyrien O, Keng PC, Smudzin T, Anderson J, Qazi R, Smith B, Watson TJ, Feins RH, Johnstone DW. "Preclinical and pilot clinical studies of docetaxel chemoradiation for Stage III non-small-cell lung cancer." International journal of radiation oncology, biology, physics. 2011 Aug 1; 80(5):1358-64. Epub 2010 Aug 12.
2011 Aug
Kaspler P, Chen R, Hyrien O, Jelveh S, Bristow RG, Hill RP. "Biodosimetry using radiation-induced micronuclei in skin fibroblasts." International journal of radiation biology. 2011 Aug; 87(8):824-38.
2011 Jul 1
Chen R, Hyrien O. "Quasi- and pseudo-maximum likelihood estimators for discretely observed continuous-time Markov branching processes." Journal of statistical planning and inference. 2011 Jul 1; 141(7):2209-2227.
2011 Jan
Chen R, Hyrien O, Noble M, Mayer-Pröschel M. "A composite likelihood approach to the analysis of longitudinal clonal data on multitype cellular systems under an age-dependent branching process." Biostatistics. 2011 Jan; 12(1):173-91. Epub 2010 Aug 23.
2010 Jun 22
Hyrien O, Chen R, Zand MS. "An age-dependent branching process model for the analysis of CFSE-labeling experiments." Biology direct. 2010 Jun 22; 5:41. Epub 2010 Jun 22.
2010 Jun
Hyrien O, Chen R, Mayer-Pröschel M, Noble M. "Saddlepoint approximations to the moments of multitype age-dependent branching processes, with applications." Biometrics. 2010 Jun; 66(2):567-77. Epub 2009 Jun 09.
2010 Jun
Dertinger SD, Phonethepswath S, Franklin D, Weller P, Torous DK, Bryce SM, Avlasevich S, Bemis JC, Hyrien O, Palis J, Macgregor JT. "Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies." Toxicological sciences : an official journal of the Society of Toxicology. 2010 Jun; 115(2):401-11. Epub 2010 Mar 04.
2010 May 1
Biswas T, Dhakal S, Chen R, Hyrien O, Bernstein S, Friedberg JW, Fisher RI, Liesveld J, Phillips G, Constine LS. "Involved field radiation after autologous stem cell transplant for diffuse large B-cell lymphoma in the rituximab era." International journal of radiation oncology, biology, physics. 2010 May 1; 77(1):79-85. Epub 2009 Aug 03.
2010 Mar
Phonethepswath S, Franklin D, Torous DK, Bryce SM, Bemis JC, Raja S, Avlasevich S, Weller P, Hyrien O, Palis J, Macgregor JT, Dertinger SD. "Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens." Toxicological sciences : an official journal of the Society of Toxicology. 2010 Mar; 114(1):59-70. Epub 2009 Dec 04.
2010 Feb
Chen Y, Tsai Y, Nowak I, Wang N, Hyrien O, Wilkins R, Ferrarotto C, Sun H, Dertinger SD. "Validating high-throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and CBMN assays in a mouse model." Health physics. 2010 Feb; 98(2):218-27.
2010 Feb
Kaspler P, Hyrien O, Hill RP. "Dynamics of micronuclei in mouse skin fibroblasts after gamma irradiation." Health physics. 2010 Feb; 98(2):228-33.
2010 Jan
Bhogal N, Kaspler P, Jalali F, Hyrien O, Chen R, Hill RP, Bristow RG. "Late residual gamma-H2AX foci in murine skin are dose responsive and predict radiosensitivity in vivo." Radiation research. 2010 Jan; 173(1):1-9.
Hyrien O, Dietrich J, Noble M. "Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors." Cancer research. 2010 70(24):10051-9. Epub 2010 Nov 05.
Hyrien O, Yanev NM. "Modeling Cell Kinetics using Branching Processes with Non-Homogeneous Poisson Immigration." Comptes rendus de l'Académie Bulgare des sciences : sciences mathématiques et naturelles. 2010 63(10):1405-1414.
2009 Nov 15
Hilchey SP, Kobie JJ, Cochran MR, Secor-Socha S, Wang JC, Hyrien O, Burack WR, Mosmann TR, Quataert SA, Bernstein SH. "Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness." The Journal of immunology : official journal of the American Association of Immunologists. 2009 Nov 15; 183(10):6157-66. Epub 2009 Oct 28.
2009 Sep 1
Henn AD, Rebhahn J, Brown MA, Murphy AJ, Coca MN, Hyrien O, Pellegrin T, Mosmann T, Zand MS. "Modulation of single-cell IgG secretion frequency and rates in human memory B cells by CpG DNA, CD40L, IL-21, and cell division." The Journal of immunology : official journal of the American Association of Immunologists. 2009 Sep 1; 183(5):3177-87. Epub 2009 Aug 12.
2009 Jul 8
Hocdé SA, Hyrien O, Waugh RE. "Molecular accessibility in relation to cell surface topography and compression against a flat substrate." Biophysical journal. 2009 Jul 8; 97(1):369-78.
2009 Jul 8
Hocdé SA, Hyrien O, Waugh RE. "Cell adhesion molecule distribution relative to neutrophil surface topography assessed by TIRFM." Biophysical journal. 2009 Jul 8; 97(1):379-87.
2009 Apr 30
Dertinger SD, Bemis JC, Phonethepswath S, Tsai Y, Nowak I, Hyrien O, Palis J, Chen Y. "Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age." Mutation research. 2009 Apr 30; 675(1-2):77-80. Epub 2009 Feb 11.
2009 Apr 16
Hilchey SP, Hyrien O, Mosmann TR, Livingstone AM, Friedberg JW, Young F, Fisher RI, Kelleher RJ, Bankert RB, Bernstein SH. "Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" of rituximab." Blood. 2009 Apr 16; 113(16):3809-12. Epub 2009 Feb 04.
Sun H, Dertinger SD, Hyrien O, Wu JH, Chen Y. "Gamma-radiation induces micronucleated reticulocytes in 3D bone marrow bioreactors in vitro." Mutation research. 2009 680(1-2):49-55. Epub 2009 Sep 26.
2008 Nov
Khorana AA, Francis CW, Menzies KE, Wang JG, Hyrien O, Hathcock J, Mackman N, Taubman MB. "Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer." Journal of thrombosis and haemostasis : JTH. 2008 Nov; 6(11):1983-5. Epub 2008 Sep 15.
2008 Jun
Zhang H, Hyrien O, Pandya KJ, Keng PC, Chen Y. "Tumor response kinetics after schedule-dependent paclitaxel chemoradiation treatment for inoperable non-small cell lung cancer: a model for low-dose chemotherapy radiosensitization." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2008 Jun; 3(6):563-8.
Hyrien O. and Zand M.S. "A mixture model with dependent observations for the analysis of CFSE-labeling experiments." Journal of the American Statistical Association. 2008; 103(481): 222-239. Link
Connolly GC, Chen R, Hyrien O, Mantry P, Bozorgzadeh A, Abt P, Khorana AA. "Incidence, risk factors and consequences of portal vein and systemic thromboses in hepatocellular carcinoma." Thrombosis research. 2008 122(3):299-306. Epub 2007 Nov 28.
Couderc JP, McNitt S, Hyrien O, Vaglio M, Xia X, Polonsky S, Moss AJ, Zareba W. "Improving the detection of subtle I(Kr)-inhibition: assessing electrocardiographic abnormalities of repolarization induced by moxifloxacin." Drug safety : an international journal of medical toxicology and drug experience. 2008 31(3):249-60.
Dertinger SD, Tsai Y, Nowak I, Hyrien O, Sun H, Bemis JC, Torous DK, Keng P, Palis J, Chen Y. "Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry." Mutation research. 2007 634(1-2):119-25. Epub 2007 Jul 05.
Hyrien, O. "A pseudo-maximum likelihood estimator for discretely observed multitype Bellman-Harris branching processes." Journal of Statistical Planning and Inference. 2007; 137(4): 1375-1388. Link
Connolly, G.C.; Khorana, A.; Mantry, P.; Bozorgzadeh, A.; Abt, P.; Chen, R.; Hyrien, O. "Portal vein and systemic thromboses in hepatocellular carcinoma". Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings (Post-Meeting Edition). 2007; 25(18S (June 20 Supplement)): 155048.
2006 May 17
Hyrien O, Ambeskovic I, Mayer-Proschel M, Noble M, Yakovlev A. "Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data." Theoretical biology & medical modelling. 2006 May 17; 3:21. Epub 2006 May 17.
2006 Apr 21
Hanin L, Hyrien O, Bedford J, Yakovlev A. "A comprehensive stochastic model of irradiated cell populations in culture." Journal of theoretical biology. 2006 Apr 21; 239(4):401-16. Epub 2005 Sep 19.
Hyrien, O.; Mayer-Proschel, M.; Nobel, M.; Yakovlev, A. "The statistical analysis of longitudinal clonal data on oligodendrocytes generation." WSEAS Transactions on Biology and Biomedicine. 2006; : 227-232. Link
Couderc J.P.; Vaglio M.; Xia X.; McNitt S.; Hyrien O. "Electrocardiographic method for identifying moxifloxacin-induced ventricular repolarization abnormalities". Computers in Cardiology. 2006; 33: 705-708. Link
Couderc JP, Vaglio M, Xia X, McNitt S, Hyrien O. "Electrocardiographic method for identifying drug-induced repolarization abnormalities associated with a reduction of the rapidly activating delayed rectifier potassium current." Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2006 1:4010-5.
2005 May 1
Chen Y, Hyrien O, Williams J, Okunieff P, Smudzin T, Rubin P. "Interleukin (IL)-1A and IL-6: applications to the predictive diagnostic testing of radiation pneumonitis." International journal of radiation oncology, biology, physics. 2005 May 1; 62(1):260-6.
2005 Mar
Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. "A stochastic model to analyze clonal data on multi-type cell populations." Biometrics. 2005 Mar; 61(1):199-207.
2005 Feb
Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. "Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture." Mathematical biosciences. 2005 Feb; 193(2):255-74. Epub 2005 Jan 22.
Baker, L, Hyrien, O and Ratka, A. "Contributions of morphine-3-glucuronide and morphine-6-glucoronide to differences in morphine analgesia in humans." American Journal of Pain Management. 2003; 13: 16-28.
Klés V, Hyrien O, Poul JM, Sanders P. "Application of pharmacokinetic/pharmacodynamic and stochastic modelling to 6-mercaptopurine micronucleus induction in mouse bone marrow erythrocytes." Journal of applied toxicology : JAT. 2003 23(1):59-70.
2001 Jan
Hyrien O, Klés V, Concordet D, Bonneu M, Laurentie M, Sanders P. "Stochastic modeling in toxicokinetics. Application to the in vivo micronucleus assay." Mathematical biosciences. 2001 Jan; 169(1):27-51.
1999 Jul 21
Godard T, Fessard V, Huet S, Mourot A, Deslandes E, Pottier D, Hyrien O, Sichel F, Gauduchon P, Poul J. "Comparative in vitro and in vivo assessment of genotoxic effects of etoposide and chlorothalonil by the comet assay." Mutation research. 1999 Jul 21; 444(1):103-16.