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Wei Hsu, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-7802

Fax: (585) 276-0190

Research Labs

Current Projects: Craniofacial Morphogenesis; Breast Development and Cancer; Stem Cell Biology; Ubiquitin-like Modifiers in Development and Disease; G protein-coupled receptor in Wnt signaling.

Lab: (585) 275-7851

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Faculty Appointments



Genetic Regulatory Circuits in Development and Disease
1. Craniofacial Morphogenesis
The primary objective is to investigate the fundamental mechanisms underlying craniofacial skeletogenesis, including development of cranial neural crest, tooth development, palatogenesis and calvarial morphogenesis. We currently focus on the interplay of Wnt, FGF and BMP pathways essential for expansion, cell fate determination and differentiation of the skeletal precursors. By elucidating these genetic regulatory networks, we hope to advance the knowledge base of skeletal deformities.
2. Breast Development and Cancer
The main focus is to elucidate the mechanisms by which Wnt signaling regulates stem/progenitor cells at different phases of breast development and their involvements in malignant transformation. We are particularly interested in the role of these precursor cells during parity-mediated remodeling of the mammary gland. Our current efforts focus on the role of mammary stem cells in development and cancer.
3. Stem Cell Biology
This is an integral part of our projects studying the genetic control of cellular signals and signal transduction mechanisms underlying development of lineage-specific stem cells/progenitors in skeletal, nervous and reproductive systems.
4. Ubiquitin-like Modifiers
A multi-disciplinary approach is used to study the SUMO (small ubiquitin-related modifier) pathway in mammalian development and disease. We are determining the role of SUMO-specific protease 2 in placental insufficiencies, cardiovascular, skeletal and neurological disorders, and cancers.
5. Wnt Production and Signaling
This project deciphers the regulatory mechanism underlying the making of Wnt and its signaling effects in signal-producing and signal-receiving cells. The main focus is to test our hypothesis that the newly identified Gpr177/mouse Wntless is a master regulator for intracellular trafficking of Wnt. We currently investigate the reciprocal regulation of Wnt and Gpr177 in craniofacial, skeletal, skin, tooth and mammary development, as well as the Gpr177-mediated regulation of Wnt in birth defects and cancers.



BS | Taiwan - Non-Medical School

M Ph | CUNY, Mt Sinai Sch of Med
Biomedical Sciences

PhD | Cuny Mt Sinai Sch of Med
Biomedical Sciences

Post-doctoral Training & Residency

1994 - 1997
Postdoctoral Research Fellow Columbia University, College of Physicians and Surgeons, New York, NY 10032

1989 - 1994
Graduate Fellow Molecular Biology Center, Mount Sinai School of Medicine, New York, NY


Distinguished Alumni Award
Sponsor: Taipei Fuhsing Private School, Taiwan

Idea Award, Breast Cancer Research Program

Research Award
Sponsor: Northeast Regional Development Biology Conference

Postdoctoral Fellowship
Sponsor: National Kidney Foundation

Traveling & Research Award
Sponsor: Mount Sinai School of Medicine

Traveling & Research Award
Sponsor: Mount Sinai School of Medicine

1989 - 1994
Predoctoral Fellowship
Sponsor: Mount Sinai School of Medicine

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Journal Articles

Maruyama T, Jiang M, Abbott A, Yu HI, Huang Q, Chrzanowska-Wodnicka M, Chen EI, Hsu W. "Rap1b Is an Effector of Axin2 Regulating Crosstalk of Signaling Pathways During Skeletal Development." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 Sep 0; 32(9):1816-1828. Epub 2017 Jun 26.

Zhu XJ, Liu Y, Yuan X, Wang M, Zhao W, Yang X, Zhang X, Hsu W, Qiu M, Zhang Z, Zhang Z. "Ectodermal Wnt controls nasal pit morphogenesis through modulation of the BMP/FGF/JNK signaling axis." Developmental dynamics : an official publication of the American Association of Anatomists.. 2016 Mar 0; 245(3):414-26. Epub 2016 Jan 08.

Maruyama EO, Lin H, Chiu SY, Yu HM, Porter GA, Hsu W. "Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development." Scientific reports.. 2016 Feb 17; 6:20999. Epub 2016 Feb 17.