Wei Hsu, Ph.D.

Wei Hsu, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 611
Rochester, NY 14642

Office: (585) 275-7802
Fax: (585) 276-0190
Lab: (585) 275-7851

Journal Articles

Showing all 44 journal articles available.

2016 Mar
Zhu XJ, Liu Y, Yuan X, Wang M, Zhao W, Yang X, Zhang X, Hsu W, Qiu M, Zhang Z, Zhang Z. "Ectodermal Wnt controls nasal pit morphogenesis through modulation of the BMP/FGF/JNK signaling axis." Developmental dynamics : an official publication of the American Association of Anatomists. 2016 Mar; 245(3):414-26. Epub 2016 Jan 08.
Maruyama T, Jeong J, Sheu TJ, Hsu W. "Stem cells of the suture mesenchyme in craniofacial bone development, repair and regeneration." Nature communications. 2016 7:10526. Epub 2016 Feb 01.
Maruyama EO, Lin H, Chiu SY, Yu HM, Porter GA, Hsu W. "Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development." Scientific reports. 2016 6:20999. Epub 2016 Feb 17.
2015 Jun 15
Das S, Yu S, Sakamori R, Vedula P, Feng Q, Flores J, Hoffman A, Fu J, Stypulkowski E, Rodriguez A, Dobrowolski R, Harada A, Hsu W, Bonder EM, Verzi MP, Gao N. "Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche." Development. 2015 Jun 15; 142(12):2147-62. Epub 2015 May 26.
2014 Oct 1
Sakamori R, Yu S, Zhang X, Hoffman A, Sun J, Das S, Vedula P, Li G, Fu J, Walker F, Yang CS, Yi Z, Hsu W, Yu DH, Shen L, Rodriguez AJ, Taketo MM, Bonder EM, Verzi MP, Gao N. "CDC42 inhibition suppresses progression of incipient intestinal tumors." Cancer research. 2014 Oct 1; 74(19):5480-92. Epub 2014 Aug 11.
2014 Oct
Fu J, Yu HM, Chiu SY, Mirando AJ, Maruyama EO, Cheng JG, Hsu W. "Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration." PLoS genetics. 2014 Oct; 10(10):e1004579. Epub 2014 Oct 09.
2014 Oct
Zhu XJ, Liu Y, Dai ZM, Zhang X, Yang X, Li Y, Qiu M, Fu J, Hsu W, Chen Y, Zhang Z. "BMP-FGF signaling axis mediates Wnt-induced epidermal stratification in developing mammalian skin." PLoS genetics. 2014 Oct; 10(10):e1004687. Epub 2014 Oct 16.
2014 Sep
McGee-Lawrence ME, Carpio LR, Bradley EW, Dudakovic A, Lian JB, van Wijnen AJ, Kakar S, Hsu W, Westendorf JJ. "Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice." Bone. 2014 Sep; 66:277-86. Epub 2014 Jun 25.
2014 Mar
Li TF, Yukata K, Yin G, Sheu T, Maruyama T, Jonason JH, Hsu W, Zhang X, Xiao G, Konttinen YT, Chen D, O'Keefe RJ. "BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway." Osteoarthritis and cartilage. 2014 Mar; 22(3):481-9. Epub 2014 Jan 11.
2013 Sep
Jiang M, Ku WY, Fu J, Offermanns S, Hsu W, Que J. "Gpr177 regulates pulmonary vasculature development." Development. 2013 Sep; 140(17):3589-94. Epub 2013 Jul 24.
2013 May
Maruyama T, Jiang M, Hsu W. "Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2013 May; 28(5):1150-9.
2013 Apr 26
Zhu X, Zhao P, Liu Y, Zhang X, Fu J, Yu HM, Qiu M, Chen Y, Hsu W, Zhang Z. "Intra-epithelial requirement of canonical Wnt signaling for tooth morphogenesis." The Journal of biological chemistry. 2013 Apr 26; 288(17):12080-9. Epub 2013 Mar 24.
2013 Apr
Fu J, Hsu W. "Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis." The Journal of investigative dermatology. 2013 Apr; 133(4):890-8. Epub 2012 Nov 29.
2013 Feb 22
McGee-Lawrence ME, Li X, Bledsoe KL, Wu H, Hawse JR, Subramaniam M, Razidlo DF, Stensgard BA, Stein GS, van Wijnen AJ, Lian JB, Hsu W, Westendorf JJ. "Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice." The Journal of biological chemistry. 2013 Feb 22; 288(8):5291-302. Epub 2013 Jan 07.
Maruyama EO, Yu HM, Jiang M, Fu J, Hsu W. "Gpr177 deficiency impairs mammary development and prohibits Wnt-induced tumorigenesis." PloS one. 2013 8(2):e56644. Epub 2013 Feb 15.
2012 Aug
Dao DY, Jonason JH, Zhang Y, Hsu W, Chen D, Hilton MJ, O'Keefe RJ. "Cartilage-specific ?-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2012 Aug; 27(8):1680-94.
2012 Aug
Galloway CA, Lee H, Nejjar S, Jhun BS, Yu T, Hsu W, Yoon Y. "Transgenic control of mitochondrial fission induces mitochondrial uncoupling and relieves diabetic oxidative stress." Diabetes. 2012 Aug; 61(8):2093-104. Epub 2012 Jun 14.
Zhang YG, Wu S, Xia Y, Chen D, Petrof EO, Claud EC, Hsu W, Sun J. "Axin1 prevents Salmonella invasiveness and inflammatory response in intestinal epithelial cells." PloS one. 2012 7(4):e34942. Epub 2012 Apr 11.
2011 Aug 1
Lin C, Fisher AV, Yin Y, Maruyama T, Veith GM, Dhandha M, Huang GJ, Hsu W, Ma L. "The inductive role of Wnt-?-Catenin signaling in the formation of oral apparatus." Developmental biology. 2011 Aug 1; 356(1):40-50. Epub 2011 May 10.
2011 Jun
Jiang M, Chiu SY, Hsu W. "SUMO-specific protease 2 in Mdm2-mediated regulation of p53." Cell death and differentiation. 2011 Jun; 18(6):1005-15. Epub 2010 Dec 24.
2011 Feb
Fu J, Ivy Yu HM, Maruyama T, Mirando AJ, Hsu W. "Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development." Developmental dynamics : an official publication of the American Association of Anatomists. 2011 Feb; 240(2):365-71. Epub 2011 Jan 11.
2010 Jul
Yu HM, Jin Y, Fu J, Hsu W. "Expression of Gpr177, a Wnt trafficking regulator, in mouse embryogenesis." Developmental dynamics : an official publication of the American Association of Anatomists. 2010 Jul; 239(7):2102-9.
2010 Jan
Hsu W, Mirando AJ, Yu HM. "Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural crest cells." Developmental dynamics : an official publication of the American Association of Anatomists. 2010 Jan; 239(1):338-45.
Maruyama T, Mirando AJ, Deng CX, Hsu W. "The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development." Science signaling. 2010 3(123):ra40. Epub 2010 May 25.
Chiu SY, Maruyama EO, Hsu W. "Derivation of mouse trophoblast stem cells from blastocysts." Journal of visualized experiments : JoVE. 2010 (40)Epub 2010 Jun 08.
Mirando AJ, Maruyama T, Fu J, Yu HM, Hsu W. "?-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis." BMC developmental biology. 2010 10:116. Epub 2010 Nov 26.
2009 Nov 3
Fu J, Jiang M, Mirando AJ, Yu HM, Hsu W. "Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation." Proceedings of the National Academy of Sciences of the United States of America. 2009 Nov 3; 106(44):18598-603. Epub 2009 Oct 19.
2009 Oct 1
Yan Y, Tang D, Chen M, Huang J, Xie R, Jonason JH, Tan X, Hou W, Reynolds D, Hsu W, Harris SE, Puzas JE, Awad H, O'Keefe RJ, Boyce BF, Chen D. "Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice." Journal of cell science. 2009 Oct 1; 122(Pt 19):3566-78. Epub 2009 Sep 08.
2009 Jun 16
Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, Magnuson MA, Serup P, Gu G. "Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function." Proceedings of the National Academy of Sciences of the United States of America. 2009 Jun 16; 106(24):9715-20. Epub 2009 Jun 01.
2008 Sep
Liu B, Yu HM, Huang J, Hsu W. "Co-opted JNK/SAPK signaling in Wnt/beta-catenin-induced tumorigenesis." Neoplasia : an international journal for oncology research. 2008 Sep; 10(9):1004-13.
Chiu SY, Asai N, Costantini F, Hsu W. "SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages." PLoS biology. 2008 6(12):e310.
2007 Feb
Yu HM, Liu B, Costantini F, Hsu W. "Impaired neural development caused by inducible expression of Axin in transgenic mice." Mechanisms of development. 2007 Feb; 124(2):146-56. Epub 2006 Oct 11.
2007 Jan 1
Liu B, Yu HM, Hsu W. "Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation." Developmental biology. 2007 Jan 1; 301(1):298-308. Epub 2006 Oct 21.
2005 Jun 14
Yu HM, Liu B, Chiu SY, Costantini F, Hsu W. "Development of a unique system for spatiotemporal and lineage-specific gene expression in mice." Proceedings of the National Academy of Sciences of the United States of America. 2005 Jun 14; 102(24):8615-20. Epub 2005 Jun 07.
2005 Apr
Yu HM, Jerchow B, Sheu TJ, Liu B, Costantini F, Puzas JE, Birchmeier W, Hsu W. "The role of Axin2 in calvarial morphogenesis and craniosynostosis." Development. 2005 Apr; 132(8):1995-2005.
Hsu W, Shakya R, Costantini F. "Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice." The Journal of cell biology. 2001 155(6):1055-64. Epub 2001 Dec 10.
2000 Oct 5
Julius MA, Schelbert B, Hsu W, Fitzpatrick E, Jho E, Fagotto F, Costantini F, Kitajewski J. "Domains of axin and disheveled required for interaction and function in wnt signaling." Biochemical and biophysical research communications. 2000 Oct 5; 276(3):1162-9.
1999 Feb 5
Hsu W, Zeng L, Costantini F. "Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain." The Journal of biological chemistry. 1999 Feb 5; 274(6):3439-45.
1997 Jul 11
Zeng L, Fagotto F, Zhang T, Hsu W, Vasicek TJ, Perry WL, Lee JJ, Tilghman SM, Gumbiner BM, Costantini F. "The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation." Cell. 1997 Jul 11; 90(1):181-92.
1994 Oct
Klampfer L, Lee TH, Hsu W, Vilcek J, Chen-Kiang S. "NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1." Molecular and cellular biology. 1994 Oct; 14(10):6561-9.
1994 Jan
Hsu W, Kerppola TK, Chen PL, Curran T, Chen-Kiang S. "Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region." Molecular and cellular biology. 1994 Jan; 14(1):268-76.
1993 Apr
Hsu W, Chen-Kiang S. "Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells." Molecular and cellular biology. 1993 Apr; 13(4):2515-23.
1993 Feb
Chen-Kiang S, Hsu W, Natkunam Y, Zhang X. "Nuclear signaling by interleukin-6." Current opinion in immunology. 1993 Feb; 5(1):124-8.
1992 Feb
Spergel JM, Hsu W, Akira S, Thimmappaya B, Kishimoto T, Chen-Kiang S. "NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A." Journal of virology. 1992 Feb; 66(2):1021-30.