Research Bio
Normal function of the salivary glands is critical for the maintenance of oral health. Radiation treatment of patients with head and neck cancers, as well as autoimmune diseases such as Sjögren's syndrome cause cellular damage in the salivary glands that is usually severe, irreversible, and impairs normal function. The long-range goal of this laboratory is to establish therapeutic strategies for repair or regeneration of the salivary glands. Basic research projects in our laboratory include the identification and characterization of progenitor cells involved in salivary gland development and regeneration, and the factors required for differentiation of secretory cells. Applied projects address strategies for protection of the salivary glands from radiation-induced damage, and for promoting regeneration of damaged glands.
2016
Maruyama EO, Aure MH, Xie X, Myal Y, Gan L, Ovitt CE. "Cell-Specific Cre Strains For Genetic Manipulation in Salivary Glands." PloS one. 2016 11(1):e0146711. Epub 2016 Jan 11. |
2015 Nov
Aure MH, Arany S, Ovitt CE. "Salivary Glands: Stem Cells, Self-duplication, or Both?" Journal of dental research. 2015 Nov; 94(11):1502-7. Epub 2015 Aug 18. |
2015 Jun
Shubin AD, Felong T, Graunke D, Ovitt CE, Benoit D. "Development of poly(ethylene glycol) hydrogels for salivary gland tissue engineering applications." Tissue engineering. Part A. 2015 Jun; 21(11-12):1733-51. Epub 2015 Apr 17. |
2015 Apr 20
Aure MH, Konieczny SF, Ovitt CE. "Salivary gland homeostasis is maintained through acinar cell self-duplication." Developmental cell. 2015 Apr 20; 33(2):231-7. Epub 2015 Apr 02. |
2013 Jun
Arany S, Benoit DS, Dewhurst S, Ovitt CE. "Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo." Molecular therapy : the journal of the American Society of Gene Therapy. 2013 Jun; 21(6):1182-94. Epub 2013 Mar 19. |
