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Catherine E. Ovitt, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-2920

Fax: (585) 276-0190

Research Labs

Lab: (585) 273-3076

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Faculty Appointments



Normal function of the salivary glands is critical for the maintenance of oral health. Radiation treatment of patients with head and neck cancers, as well as autoimmune diseases such as Sjögren's syndrome cause cellular damage in the salivary glands that is usually severe, irreversible, and impairs normal function. The long-range goal of this laboratory is to establish therapeutic strategies for repair or regeneration of the salivary glands. Basic research projects in our laboratory include the identification and characterization of progenitor cells involved in salivary gland development and regeneration, and the factors required for differentiation of secretory cells. Applied projects address strategies for protection of the salivary glands from radiation-induced damage, and for promoting regeneration of damaged glands.



BS | University of Connecticut
Arts & Sciences

PhD | Washington University
Molecular Biology

Post-doctoral Training & Residency

1987 - 1997
Postdoctoral Fellow, European Molecular Biology Laboratory, Heidelberg, Germany


Journal Articles

Gao X, Oei MS, Ovitt CE, Sincan M, Melvin JE. "Transcriptional profiling reveals gland-specific differential expression in the three major salivary glands of the adult mouse." Physiological genomics.. 2018 Apr 1; 50(4):263-271. Epub 2018 Jan 26.

Varghese JJ, Schmale IL, Mickelson D, Hansen ME, Newlands SD, Benoit DSW, Korshunov VA, Ovitt CE. "Localized Delivery of Amifostine Enhances Salivary Gland Radioprotection." Journal of dental research.. 2018 Apr 1; :22034518767408. Epub 2018 Apr 01.

Malcolm DW, Varghese JJ, Sorrells JE, Ovitt CE, Benoit DSW. "The Effects of Biological Fluids on Colloidal Stability and siRNA Delivery of a pH-Responsive Micellar Nanoparticle Delivery System." ACS nano.. 2018 Jan 23; 12(1):187-197. Epub 2017 Dec 15.

Books & Chapters

Chapter Title: The molecular biology of Oct-4 in the early mouse embryo
Book Title: Molecular Human Redproduction
Author List: Ovitt Ce; Scholer HR.
Published By: Molecular Human Reproduction1998

Chapter Title: Transgenic analysis of embryonic expression using LacZ as a reporter.
Book Title: Microinjection and Transgenesis. Strategies and protocols.
Author List: Ovitt, C.E.;Yeom, Y.I.; Schöler, H.R.
Edited By: Cid-Arregui, A.; García-Carrancá
Published By: Springer-Verlag1998 in Heidelberg, Berlin

Chapter Title: Oct-4: more than just a POUerful marker of the mammalian germline?
Book Title: APMIS
Author List: Brehm, A.; Ovitt, C.E.; Schöler, H.R.
Published By: APMIS1998