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Catherine E. Ovitt, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-2920

Fax: (585) 276-0190

Research Labs

Faculty Appointments

Biography

Research

Normal function of the salivary glands is critical for the maintenance of oral health. Radiation treatment of patients with head and neck cancers, as well as autoimmune diseases such as Sjögren's syndrome cause cellular damage in the salivary glands that is usually severe, irreversible, and impairs normal function. The long-range goal of this laboratory is to establish therapeutic strategies for repair or regeneration of the salivary glands. Basic research projects in our laboratory include the identification and characterization of progenitor cells involved in salivary gland development and regeneration, and the factors required for differentiation of secretory cells. Applied projects address strategies for protection of the salivary glands from radiation-induced damage, and for promoting regeneration of damaged glands.

Credentials

Education

1977
BS | University of Connecticut
Arts & Sciences

1987
PhD | Washington University
Molecular Biology

Post-doctoral Training & Residency

1987 - 1997
Postdoctoral Fellow, European Molecular Biology Laboratory, Heidelberg, Germany

Awards

2016
Elected "Salivary Gland Researcher of the Year"
Sponsor: IADR Salivary Gland Research Group

2016
International Association of Dental Research Innovation in Oral Care Award
Sponsor: International Association of Dental Research

1987 - 1990
Postdoctoral Fellowship Award
Sponsor: Alexander von Humboldt Foundation, Germany

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Publications

Journal Articles

1/2020
Shubin AD, Sharipol A, Felong TJ, Weng PL, Schutrum BE, Joe DS, Aure MH, Benoit DSW, Ovitt CE. "Stress or injury induces cellular plasticity in salivary gland acinar cells." Cell Tissue Res. 2020; [Epub ahead of print].

9/27/2019
Weng PL, Luitje ME, Ovitt CE. "Cellular Plasticity in Salivary Gland Regeneration." Oral diseases.. 2019 Sep 27; Epub 2019 Sep 27.

9/20/2019
Ingalls MH, Hollomon AJ, Newlands SD, McDavid AN, Ovitt CE. "Intrinsic mitotic activity supports the human salivary gland acinar cell population." FEBS letters.. 2019 Sep 20; Epub 2019 Sep 20.

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