Skip to main content
Explore URMC

URMC Logo

menu

Kye-Im Jeon, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Faculty Appointments

Biography

Research

Dr. Jeon has a long-standing interest in contractile cells. Earlier in her career, she investigated the differentiation and proliferation of smooth muscle cells, such as those that occur during pathological vascular remodeling in atherosclerosis and restenosis.

During the last few years, Dr. Jeon has turned her attention to corneal wound healing and, in particular, the differentiation from fibroblasts to myofibroblasts. At first, this work focused on ways of pharmacologically controlling this process, especially using PPARs ligands. These ligands are already clinically used for the treatment of diabetes and are known to regulate many important cellular functions, including metabolism, adipogenesis, proliferation and differentiation in a variety of body tissues. Relevant to the cornea, we found PPARs ligands capable of inhibiting myofibroblast differentiation in vivo and in vitro, identifying them as a potentially exciting, new class of topical ocular therapeutics.

While pursuing this project, Dr. Jeon's team also discovered that myofibroblast transformation – such as occurs in large corneal wounds - directly inhibits nerve regeneration in vivo and in vitro. Her current efforts are focused on understanding the interaction between myofibroblasts and neurons. Controlling corneal re-innervation after wounding has important implications for blinding conditions such as neurotrophic keratitis, where persistent corneal wounds occur.

Credentials

Education

1995
MS | Korea-Yonsei University
Biochemistry

2001
PhD | Korea-Catholic Med Coll, Seoul
Biochemistry

Publications

Journal Articles

8/28/2018
Jeon KI, Hindman HB, Bubel T, McDaniel T, DeMagistris M, Callan C, Huxlin KR. "Corneal myofibroblasts inhibit regenerating nerves during wound healing." Scientific reports.. 2018 Aug 28; 8(1):12945. Epub 2018 Aug 28.

9/2015
Jeon KI, Phipps RP, Sime PJ, Huxlin KR. "Inhibitory effects of PPAR? ligands on TGF-?1-induced CTGF expression in cat corneal fibroblasts." Experimental eye research.. 2015 Sep 0; 138:52-8. Epub 2015 Jul 02.

5/2014
Jeon KI, Kulkarni A, Woeller CF, Phipps RP, Sime PJ, Hindman HB, Huxlin KR. "Inhibitory effects of PPAR? ligands on TGF-?1-induced corneal myofibroblast transformation." The American journal of pathology.. 2014 May 0; 184(5):1429-45. Epub 2014 Mar 17.

VIEW ALL PUBLICATIONS