Kye-Im Jeon, Ph.D.

Kye-Im Jeon, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 659
Rochester, NY 14642

Research Bio

Dr. Jeon has a long-standing interest in contractile cells. Earlier in her career, she investigated the differentiation and proliferation of smooth muscle cells, such as those that occur during pathological vascular remodeling in atherosclerosis and restenosis.



During the last few years, Dr. Jeon has turned her attention to corneal wound healing and, in particular, the differentiation from fibroblasts to myofibroblasts. At first, this work focused on ways of pharmacologically controlling this process, especially using PPARs ligands. These ligands are already clinically used for the treatment of diabetes and are known to regulate many important cellular functions, including metabolism, adipogenesis, proliferation and differentiation in a variety of body tissues. Relevant to the cornea, we found PPARs ligands capable of inhibiting myofibroblast differentiation in vivo and in vitro, identifying them as a potentially exciting, new class of topical ocular therapeutics.

While pursuing this project, Dr. Jeon's team also discovered that myofibroblast transformation – such as occurs in large corneal wounds - directly inhibits nerve regeneration in vivo and in vitro. Her current efforts are focused on understanding the interaction between myofibroblasts and neurons. Controlling corneal re-innervation after wounding has important implications for blinding conditions such as neurotrophic keratitis, where persistent corneal wounds occur.

Recent Journal Articles

Showing the 5 most recent journal articles. 12 available »

2014 May
Jeon KI, Kulkarni A, Woeller CF, Phipps RP, Sime PJ, Hindman HB, Huxlin KR. "Inhibitory effects of PPAR? ligands on TGF-?1-induced corneal myofibroblast transformation." The American journal of pathology. 2014 May; 184(5):1429-45. Epub 2014 Mar 17.
2013
Huxlin KR, Hindman HB, Jeon KI, Bühren J, Macrae S, Demagistris M, Ciufo D, Sime PJ, Phipps RP. "Topical rosiglitazone is an effective anti-scarring agent in the cornea." PloS one. 2013 8(8):e70785. Epub 2013 Aug 05.
2011 Mar
Cai Y, Miller CL, Nagel DJ, Jeon KI, Lim S, Gao P, Knight PA, Yan C. "Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells." Arteriosclerosis, thrombosis, and vascular biology. 2011 Mar; 31(3):616-23. Epub 2010 Dec 09.
2010 May 25
Jeon KI, Xu X, Aizawa T, Lim JH, Jono H, Kwon DS, Abe JI, Berk BC, Li JD, Yan C. "Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism." Proceedings of the National Academy of Sciences of the United States of America. 2010 May 25; 107(21):9795-800. Epub 2010 May 06.
2010
Jeon KI, Jono H, Miller CL, Cai Y, Lim S, Liu X, Gao P, Abe JI, Li JD, Yan C. "Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells." The FEBS journal. 2010 277(24):5026-39. Epub 2010 Nov 16.

Current Appointments

Research Assistant Professor - Department of Ophthalmology (SMD) - Primary

Education

PhD | Biochemistry | Korea-Catholic Med Coll, Seoul2001
MS | Biochemistry | Korea-Yonsei University1995