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Arshad Rahman, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-5948

Biography

Research

Dr. Rahman's research interests are:
1) Signaling Mechanisms of Endothelial ICAM-1 Expression
2) Neutrophil-mediated Lung Injury.

They want to know how pro-inflammatory mediators such as thrombin and tumor necrosis factor alpha (TNF) mediate neutrophils (PMN) sequestration and emigration in the lung and thus induce lung vascular injury. In particular, they are interested in defining the critical signaling pathways mediating expression of intercellular adhesion molecule (CAM-1; CD54), an inducible endothelial adhesive protein that serves as a counter-receptor for ²2-integrins (CD11/CD18) present on the surface of leukocytes. Interaction of ICAM-1 with ²2-integrins enables PMN to adhere firmly and stably to the vascular endothelium, and to migrate across the endothelial barrier. PMN binding to endothelial cells by this mechanism contributes to the development of lung vascular injury and tissue edema.

Dr. Rahman uses multidisciplinary approaches ranging from cultured endothelial cells and in vivo mouse models with targeted gene deletions to molecular biology and lung physiology to address these questions of fundamental importance.

Credentials

Faculty Appointments

Education

1981
BSc | AM University
Chemistry

1988
PhD | AM University
Biochemistry

1984
MSc | AM University
Biochemistry

Publications

Journal Articles

11/2016
Angara S, Syed M, Das P, Janér C, Pryhuber G, Rahman A, Andersson S, Homer RJ, Bhandari V. "Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice." American journal of respiratory cell and molecular biology.. 2016 Nov 0; 55(5):722-735.

8/1/2016
Bijli KM, Fazal F, Slavin SA, Leonard A, Grose V, Alexander WB, Smrcka AV, Rahman A. "Phospholipase C-? signaling mediates endothelial cell inflammation and barrier disruption in acute lung injury." American journal of physiology. Lung cellular and molecular physiology.. 2016 Aug 1; 311(2):L517-24. Epub 2016 Jul 01.

8/1/2015
Solleti SK, Simon DM, Srisuma S, Arikan MC, Bhattacharya S, Rangasamy T, Bijli KM, Rahman A, Crossno JT, Shapiro SD, Mariani TJ. "Airway epithelial cell PPAR? modulates cigarette smoke-induced chemokine expression and emphysema susceptibility in mice." American journal of physiology. Lung cellular and molecular physiology.. 2015 Aug 1; 309(3):L293-304. Epub 2015 May 29.

Books & Chapters

2007
Chapter Title: Nuclear Factor-kappaB Signaling in Endothelium
Book Title: Endothelial Biomedicine
Author List: Bijli KM, Rahman A
Edited By: Aird WC
Published By: Cambridge University Press2007

1996
Chapter Title: Transcriptional regulation of endothelial adhesion molecule gene expression by oxidants and cytokines.
Book Title: Nitric Oxide and Radicals in the Pulmonary Vasculature. Proceedings of the VII
Author List: Rahman A, Roebuck KA, Malik AB
Edited By: Weir EK, Archer SL, Reeves JT
Published By: Futura Publishing Co.1996 in New York, NY

1993
Chapter Title: Strand scission in DNA induced by dietary flavonoids: role of Cu(I) and oxygen free radicals.
Book Title: Glimpses in Plant Research XI: Medicinal Plants; New Vistas of Research-Part 2
Author List: Rahman A, Fazal F, Hadi SM
Edited By: Govil JN, Singh VK, Hashmi S
Published By: Today and Tomorrow's Printers and Publishers1993 in New Delhi, India

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