Skip to main content
Explore URMC

URMC Logo

menu

Bin Liu, B.Med.

Contact Information

Phone Numbers

Fax: (585) 276-9830

Research Labs

Lab: (585) 275-1324

Visit Lab Website

Biography

Monocyte chemoattractant protein-1 (MCP-1) promotes atherosclerosis and other inflammatory diseases. Platelet-derived growth factor B form (PDGF-B) and angiotensin II (Ang II) are key regulators of MCP-1 in smooth muscle cells (SMC) which make a great contribution to the development of atherosclerosis. Complete insight into the mechanisms by which PDGF-B and Ang II regulate stability of MCP-1 mRNA may provide a better approach to develop an efficient drug to control MCP-1, thus to control inflammatory diseases such as atherosclerosis. Translational projects bridge the mechanism study and drug development will be proposed and carried out as more details of the mechanisms are revealed.

Research

My research is focused on the regulation of mRNA stability of monocyte chemoattractant protein-1 (MCP-1) by PDGF and Angiotensin II (Ang II) in smooth muscle cells (SMC). MCP-1 promotes atherosclerosis and is a mediator of the response to arterial injury. MCP-1 level tracks its mRNA level under physiological or pathological conditions in animal models. MCP-1 mRNA is markedly elevated in response to PDGF-B or Ang II elevation largely due to increase of mRNA stability. Both PDGF-B and Ang II stabilize MCP-1 mRNA through a PKCd-dependent signaling pathway. Our ongoing research is to fully figure out the signaling pathways mediating the mRNA stabilizing effect, to isolate the MCP-1 mRNA stabilizing factor induced by PDGF-B and Ang II, and to reveal the RNases involved in PDGF-b and Ang II induced MCP-1 mRNA stabilization.

Credentials

Education

1982
MD | China-Bethune Med Univ, Changchun
Medicine

Publications

Journal Articles

4/6/2007
Dhawan L, Liu B, Blaxall BC, Taubman MB. "A novel role for the glucocorticoid receptor in the regulation of monocyte chemoattractant protein-1 mRNA stability." The Journal of biological chemistry.. 2007 Apr 6; 282(14):10146-52. Epub 2007 Feb 02.

4/2006
Liu B, Jiang S, Zhang W, Ye F, Wang YH, Wu J, Zhang DY. "Novel biodegradable HSAM nanoparticle for drug delivery." Oncology reports.. 2006 Apr 0; 15(4):957-61.

2006
Liu, B.; Poon, M.; Taubman, MB. "PDGF-BB Enhances Monocyte chemoattractant protein-1 mRNA Stability in Smooth Muscle Cells by Downregulating ribonuclease Activity." Journal of Mol Cell Cardio. 2006; 3: 426.

VIEW ALL PUBLICATIONS