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Bonnie K. Baxter, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-5358

Biography

Research

Fungal infections are a serious and growing problem among people with compromised immunity, including those undergoing or recovering from chemotherapy and people with HIV/AIDS. There are very few effective anti-fungal drugs, particularly when compared to the arsenal available to treat bacterial infections.

In collaboration with Dr. Damian Krysan, Dr. Melanie Wellington and the members of their laboratories, I am using a novel high-throughput assay developed in the Krysan laboratory to discover new anti-fungal compounds. We then use a variety of biochemical, genetic, and in vivo mouse experiments to characterize the compounds uncovered by the assay: to explore their mechanism of action as well as their potential utility in treating infection, either alone or in combination with other anti-fungal compounds.

Because of its unique characteristics and thus lack of overlap with the human host, we are particularly interested in compounds that affect the fungal cell wall, and we are using genetic approaches to bias our chemical library screening toward this class of compounds. The fungal cell wall is relatively poorly understood, and we expect these compounds to be useful not only in treating fungal infections, but also in helping us understand cell wall structure and function.

Credentials

Education

1990
BA | Butler University
Psychology

1997
PhD | University of Wisconsin
Biomolecular Chemistry

Awards

1997
University of Wisconsin Letters and Science Teaching Fellow

1995 - 1996
Wisconsin Alumni Research Foundation Graduate Fellow

1992 - 1995
National Science Foundation Graduate Fellow

1991 - 1992
Wisconsin Alumni Research Foundation Graduate Fellow

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Publications

Journal Articles

6/2010
Didone L, Scrimale T, Baxter BK, Krysan DJ. "A high-throughput assay of yeast cell lysis for drug discovery and genetic analysis." Nature protocols. 2010 Jun 0; 5(6):1107-14. Epub 2010 May 27.

2005
Baxter BK, Abeliovich H, Zhang Z, Stirling AG, Burlingame AL, Goldfarb DS. "Atg19p ubiquitination and the cytosol to vacuole trafficking pathway in yeast". Journal of Biological Chemistry. 2005; 280(47): 39067-39076.

1999
Bressan DA; Baxter BK; Petrini JHJ. "The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae". Molecular and Cellular Biology. 1999; 19: 7681-7687.

Books & Chapters

1997
Chapter Title: Saccharomyces cerevisiae SSI1
Book Title: Guidebook to Molecular Charperones and Protein Folding
Author List: Baxter BK, Craig EA
Published By: Oxford University Press1997 in New York

1994
Chapter Title: Cystosolic Hsp70s of Saccharomyces cerevisiae: Roles in Protein Synthesis, Protein Translocation, Proteolysis and Regulation
Book Title: The Biology of Heart Shock Proteins and Molecular Chaperones
Author List: Craig EA; Baxter BK, Becker J, Halladay; Ziegelhoffer T
Edited By: R. Morimoto et al
Published By: Cold Spring Harbor Laboratory Press1994 in New York

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