James J. Kobie, Ph.D.

James J. Kobie, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 695
Rochester, NY 14642

Office: (585) 275-6632
Administrative: (585) 275-2891

Journal Articles

Showing all 33 journal articles available.

Piepenbrink MS, Samuel M, Zheng B, Carter B, Fucile C, Bunce C, Kiebala M, Khan AA, Thakar J, Maggirwar SB, Morse D, Rosenberg AF, Haughey NJ, Valenti W, Keefer MC, Kobie JJ. "Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users." PloS one. 2016 11(7):e0158641. Epub 2016 Jul 05.
Keefer M, Zheng B, Rosenberg AF, Kobie JJ. "Increased Steady-State Memory B Cell Subsets Among High-Risk Participants in an HIV Vaccine Trial." AIDS research and human retroviruses. 2016 32(10-11):1143-1148.
2015 Oct 9
Li YR, Zhao SD, Li J, Bradfield JP, Mohebnasab M, Steel L, Kobie J, Abrams DJ, Mentch FD, Glessner JT, Guo Y, Wei Z, Connolly JJ, Cardinale CJ, Bakay M, Li D, Maggadottir SM, Thomas KA, Qui H, Chiavacci RM, Kim CE, Wang F, Snyder J, Flatø B, Førre Ø, Denson LA, Thompson SD, Becker ML, Guthery SL, Latiano A, Perez E, Resnick E, Strisciuglio C, Staiano A, Miele E, Silverberg MS, Lie BA, Punaro M, Russell RK, Wilson DC, Dubinsky MC, Monos DS, Annese V, Munro JE, Wise C, Chapel H, Cunningham-Rundles C, Orange JS, Behrens EM, Sullivan KE, Kugathasan S, Griffiths AM, Satsangi J, Grant SF, Sleiman PM, Finkel TH, Polychronakos C, Baldassano RN, Luning Prak ET, Ellis JA, Li H, Keating BJ, Hakonarson H. "Genetic sharing and heritability of paediatric age of onset autoimmune diseases." Nature communications. 2015 Oct 9; 6:8442. Epub 2015 Oct 09.
2015 Apr
Kobie JJ, Zheng B, Piepenbrink MS, Hessell AJ, Haigwood NL, Keefer MC, Sanz I. "Functional and Molecular Characteristics of Novel and Conserved Cross-Clade HIV Envelope Specific Human Monoclonal Antibodies." Monoclonal antibodies in immunodiagnosis and immunotherapy. 2015 Apr; 34(2):65-72.
Kiebala M, Singh MV, Piepenbrink MS, Qiu X, Kobie JJ, Maggirwar SB. "Platelet Activation in Human Immunodeficiency Virus Type-1 Patients Is Not Altered with Cocaine Abuse." PloS one. 2015 10(6):e0130061. Epub 2015 Jun 15.
2014 Sep 21
Bobo B, Phelan D, Rebhahn J, Piepenbrink MS, Zheng B, Mosmann TR, Kobie JJ, DeLouise LA. "Microbubble array diffusion assay for the detection of cell secreted factors." Lab on a chip. 2014 Sep 21; 14(18):3640-50. Epub 2014 Jul 31.
2014 Aug 15
Michaud HA, SenGupta D, de Mulder M, Deeks SG, Martin JN, Kobie JJ, Sacha JB, Nixon DF. "Cutting edge: An antibody recognizing ancestral endogenous virus glycoproteins mediates antibody-dependent cellular cytotoxicity on HIV-1-infected cells." The Journal of immunology : official journal of the American Association of Immunologists. 2014 Aug 15; 193(4):1544-8. Epub 2014 Jul 14.
Kobie JJ, Treanor JJ, Ritchlin CT. "Transient decrease in human peripheral blood myeloid dendritic cells following influenza vaccination correlates with induction of serum antibody." Immunological investigations. 2014 43(6):606-15.
2013 Oct
Jaworski JP, Kobie J, Brower Z, Malherbe DC, Landucci G, Sutton WF, Guo B, Reed JS, Leon EJ, Engelmann F, Zheng B, Legasse A, Park B, Dickerson M, Lewis AD, Colgin LM, Axthelm M, Messaoudi I, Sacha JB, Burton DR, Forthal DN, Hessell AJ, Haigwood NL. "Neutralizing polyclonal IgG present during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaques." Journal of virology. 2013 Oct; 87(19):10447-59. Epub 2013 Jul 24.
2013 Jun
Jones MC, Kobie JJ, Delouise LA. "Characterization of cell seeding and specific capture of B cells in microbubble well arrays." Biomedical microdevices. 2013 Jun; 15(3):453-63.
2013 Mar 12
Sullivan MA, Brooks LR, Weidenborner P, Domm W, Mattiacio J, Xu Q, Tiberio M, Wentworth T, Kobie J, Bryk P, Zheng B, Murphy M, Sanz I, Dewhurst S. "Anti-idiotypic monobodies derived from a fibronectin scaffold." Biochemistry. 2013 Mar 12; 52(10):1802-13. Epub 2013 Mar 01.
Alcéna DC, Kobie JJ, Kaminski DA, Rosenberg AF, Mattiacio JL, Brewer M, Dewhurst S, Dykes C, Jin X, Keefer MC, Sanz I. "9G4+ antibodies isolated from HIV-infected patients neutralize HIV-1 and have distinct autoreactivity profiles." PloS one. 2013 8(12):e85098. Epub 2013 Dec 26.
2012 Sep
Sullivan MA, Wentworth T, Kobie JJ, Sanz I. "Anti-idiotypic monobodies for immune response profiling." Methods : a companion to Methods in enzymology. 2012 Sep; 58(1):62-8. Epub 2012 Jul 20.
Kobie JJ, Alcena DC, Zheng B, Bryk P, Mattiacio JL, Brewer M, Labranche C, Young FM, Dewhurst S, Montefiori DC, Rosenberg AF, Feng C, Jin X, Keefer MC, Sanz I. "9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity." PloS one. 2012 7(4):e35356. Epub 2012 Apr 18.
Kobie JJ, Zheng B, Bryk P, Barnes M, Ritchlin CT, Tabechian DA, Anandarajah AP, Looney RJ, Thiele RG, Anolik JH, Coca A, Wei C, Rosenberg AF, Feng C, Treanor JJ, Lee FE, Sanz I. "Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor." Arthritis research & therapy. 2011 13(6):R209. Epub 2011 Dec 16.
2010 Dec
Qi Y, Operario DJ, Oberholzer CM, Kobie JJ, Looney RJ, Georas SN, Mosmann TR. "Human basophils express amphiregulin in response to T cell-derived IL-3." The Journal of allergy and clinical immunology. 2010 Dec; 126(6):1260-6.e4. Epub 2010 Oct 30.
2010 Apr 30
Halliley JL, Kyu S, Kobie JJ, Walsh EE, Falsey AR, Randall TD, Treanor J, Feng C, Sanz I, Lee FE. "Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunization." Vaccine. 2010 Apr 30; 28(20):3582-7. Epub 2010 Mar 16.
2009 Dec
Mosmann TR, Kobie JJ, Lee FE, Quataert SA. "T helper cytokine patterns: defined subsets, random expression, and external modulation." Immunologic research. 2009 Dec; 45(2-3):173-84. Epub 2009 Feb 06.
2009 Nov 15
Hilchey SP, Kobie JJ, Cochran MR, Secor-Socha S, Wang JC, Hyrien O, Burack WR, Mosmann TR, Quataert SA, Bernstein SH. "Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness." The Journal of immunology : official journal of the American Association of Immunologists. 2009 Nov 15; 183(10):6157-66. Epub 2009 Oct 28.
2009 Feb 28
Wang JC, Kobie JJ, Zhang L, Cochran M, Mosmann TR, Ritchlin CT, Quataert SA. "An 11-color flow cytometric assay for identifying, phenotyping, and assessing endocytic ability of peripheral blood dendritic cell subsets in a single platform." Journal of immunological methods. 2009 Feb 28; 341(1-2):106-16. Epub 2008 Dec 03.
2009 Jan 1
Kyu SY, Kobie J, Yang H, Zand MS, Topham DJ, Quataert SA, Sanz I, Lee FE. "Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells." Journal of immunological methods. 2009 Jan 1; 340(1):42-7. Epub 2008 Nov 06.
2008 Oct
Rebhahn JA, Bishop C, Divekar AA, Jiminez-Garcia K, Kobie JJ, Lee FE, Maupin GM, Snyder-Cappione JE, Zaiss DM, Mosmann TR. "Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion." Computer methods and programs in biomedicine. 2008 Oct; 92(1):54-65. Epub 2008 Jul 21.
2007 Nov 15
Hamalainen-Laanaya HK, Kobie JJ, Chang C, Zeng WP. "Temporal and spatial changes of histone 3 K4 dimethylation at the IFN-gamma gene during Th1 and Th2 cell differentiation." The Journal of immunology : official journal of the American Association of Immunologists. 2007 Nov 15; 179(10):6410-5.
2006 Dec 15
Zaiss DM, Yang L, Shah PR, Kobie JJ, Urban JF, Mosmann TR. "Amphiregulin, a TH2 cytokine enhancing resistance to nematodes." Science. 2006 Dec 15; 314(5806):1746.
2006 Nov 15
Kobie JJ, Shah PR, Yang L, Rebhahn JA, Fowell DJ, Mosmann TR. "T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine." The Journal of immunology : official journal of the American Association of Immunologists. 2006 Nov 15; 177(10):6780-6.
2006 May 1
Hahn T, Alvarez I, Kobie JJ, Ramanathapuram L, Dial S, Fulton A, Besselsen D, Walker E, Akporiaye ET. "Short-term dietary administration of celecoxib enhances the efficacy of tumor lysate-pulsed dendritic cell vaccines in treating murine breast cancer." International journal of cancer. 2006 May 1; 118(9):2220-31.
2005 Nov 15
Yang L, Kobie JJ, Mosmann TR. "CD73 and Ly-6A/E distinguish in vivo primed but uncommitted mouse CD4 T cells from type 1 or type 2 effector cells." The Journal of immunology : official journal of the American Association of Immunologists. 2005 Nov 15; 175(10):6458-64.
2004 Jul
Ramanathapuram LV, Kobie JJ, Bearss D, Payne CM, Trevor KT, Akporiaye ET. "alpha-Tocopheryl succinate sensitizes established tumors to vaccination with nonmatured dendritic cells." Cancer immunology, immunotherapy : CII. 2004 Jul; 53(7):580-8. Epub 2004 Feb 25.
2003 Apr 15
Kobie JJ, Wu RS, Kurt RA, Lou S, Adelman MK, Whitesell LJ, Ramanathapuram LV, Arteaga CL, Akporiaye ET. "Transforming growth factor beta inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines." Cancer research. 2003 Apr 15; 63(8):1860-4.
Kobie, J. J.; Akporiaye, E. T. "Immunosuppressive Role of Transforming Growth Factor –Beta in Breast Cancer". Clinical and Applied Immunology Reviews. 2003; 3: 277-287. Link
2001 Jul
Wu RS, Kobie JJ, Besselsen DG, Fong TC, Mack VD, McEarchern JA, Akporiaye ET. "Comparative analysis of IFN-gamma B7.1 and antisense TGF-beta gene transfer on the tumorigenicity of a poorly immunogenic metastatic mammary carcinoma." Cancer immunology, immunotherapy : CII. 2001 Jul; 50(5):229-40.
2001 Jan 1
McEarchern JA, Kobie JJ, Mack V, Wu RS, Meade-Tollin L, Arteaga CL, Dumont N, Besselsen D, Seftor E, Hendrix MJ, Katsanis E, Akporiaye ET. "Invasion and metastasis of a mammary tumor involves TGF-beta signaling." International journal of cancer. 2001 Jan 1; 91(1):76-82.
Kobie, J. J.; Peto, J.; Prentice, M. "Toughness response of electrodes within arc furnace cycling". Materials Evaluation. 1994; 52: 350-354.