Photo not available

Tihomir Miralem, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Lab: (585) 275-0361
Office: (585) 275-3843
Fax: (585) 275-6007

Journal Articles

Showing all 23 journal articles available.

2016 May 10
Miralem T, Lerner-Marmarosh N, Gibbs PE, Jenkins JL, Heimiller C, Maines MD. "Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 May 10; Epub 2016 May 10.
2015
Gibbs PE, Miralem T, Maines MD. "Biliverdin reductase: a target for cancer therapy?" Frontiers in pharmacology. 2015 6:119. Epub 2015 Jun 03.
2013
Nicholson TM, Uchtmann KS, Valdez CD, Theberge AB, Miralem T, Ricke WA. "Renal capsule xenografting and subcutaneous pellet implantation for the evaluation of prostate carcinogenesis and benign prostatic hyperplasia." Journal of visualized experiments : JoVE. 2013 (78)Epub 2013 Aug 28.
2012 Jul 13
Miralem T, Lerner-Marmarosh N, Gibbs PE, Tudor C, Hagen FK, Maines MD. "The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase C? activity: the peptides are inhibitors or substrate for the protein kinase C." The Journal of biological chemistry. 2012 Jul 13; 287(29):24698-712. Epub 2012 May 14.
2012 Jan 6
Gibbs PE, Miralem T, Lerner-Maramarosh N, Tudor C, Maines MD. "Formation of ternary complex of human biliverdin reductase-protein kinase C?-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-?B, and inducible nitric-oxidase synthase (iNOS)." The Journal of biological chemistry. 2012 Jan 6; 287(2):1066-79. Epub 2011 Nov 07.
2010 Sep
Gibbs PE, Miralem T, Maines MD. "Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010 Sep; 24(9):3239-54. Epub 2010 Apr 21.
2010 Apr 23
Miralem T, Gibbs PE, Revert F, Saus J, Maines MD. "Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression." The Journal of biological chemistry. 2010 Apr 23; 285(17):12551-8. Epub 2010 Feb 22.
2008 May 13
Lerner-Marmarosh N, Miralem T, Gibbs PE, Maines MD. "Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling." Proceedings of the National Academy of Sciences of the United States of America. 2008 May 13; 105(19):6870-5. Epub 2008 May 07.
2007 Mar 16
Maines MD, Miralem T, Lerner-Marmarosh N, Shen J, Gibbs PE. "Human biliverdin reductase, a previously unknown activator of protein kinase C betaII." The Journal of biological chemistry. 2007 Mar 16; 282(11):8110-22. Epub 2007 Jan 16.
2007
Lerner-Marmarosh N, Miralem T, Gibbs PE, Maines MD. "Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2007 21(14):3949-62. Epub 2007 Jul 17.
2005 Apr 29
Miralem T, Hu Z, Torno MD, Lelli KM, Maines MD. "Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells." The Journal of biological chemistry. 2005 Apr 29; 280(17):17084-92. Epub 2005 Feb 28.
2004 May 7
Kravets A, Hu Z, Miralem T, Torno MD, Maines MD. "Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1." The Journal of biological chemistry. 2004 May 7; 279(19):19916-23. Epub 2004 Feb 25.
2003 Jan
Miralem T, Avraham HK. "Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus." Molecular and cellular biology. 2003 Jan; 23(2):579-93.
2001 Sep 6
Miralem T, Steinberg R, Price D, Avraham H. "VEGF(165) requires extracellular matrix components to induce mitogenic effects and migratory response in breast cancer cells." Oncogene. 2001 Sep 6; 20(39):5511-24.
2001 Mar
Price DJ, Miralem T, Jiang S, Steinberg R, Avraham H. "Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells." Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 2001 Mar; 12(3):129-35.
1999 Oct
Wang A, Miralem T, Templeton DM. "Heparan sulfate chains with antimitogenic properties arise from mesangial cell-surface proteoglycans." Metabolism: clinical and experimental. 1999 Oct; 48(10):1220-9.
1998 Oct
Miralem T, Templeton DM. "Inactivation of kinase cascades in mesangial cells grown on collagen type I." The American journal of physiology. 1998 Oct; 275(4 Pt 2):F585-94.
1998 Mar 16
Templeton DM, Wang Z, Miralem T. "Cadmium and calcium-dependent c-fos expression in mesangial cells." Toxicology letters. 1998 Mar 16; 95(1):1-8.
1998 Mar 1
Miralem T, Templeton DM. "Heparin inhibits Ca2+/calmodulin-dependent kinase II activation and c-fos induction in mesangial cells." The Biochemical journal. 1998 Mar 1; 330 ( Pt 2):651-7.
1998 Jan
Whiteside C, Munk S, Zhou X, Miralem T, Templeton DM. "Chelation of intracellular calcium prevents mesangial cell proliferative responsiveness." Journal of the American Society of Nephrology : JASN. 1998 Jan; 9(1):14-25.
1996 Jul 19
Miralem T, Wang A, Whiteside CI, Templeton DM. "Heparin inhibits mitogen-activated protein kinase-dependent and -independent c-fos induction in mesangial cells." The Journal of biological chemistry. 1996 Jul 19; 271(29):17100-6.
1996 Jun
Miralem T, Whiteside CI, Templeton DM. "Collagen type I enhances endothelin-mediated contraction and induces nonproliferating phenotype in mesangial cells." The American journal of physiology. 1996 Jun; 270(6 Pt 2):F960-70.
1993
Van Ginkel MF, Heijink E, Dekker PB, Miralem T, van der Voet GB, de Wolff FA. "Effect of aluminum chloride, -citrate, and -maltol on the calcium-mediated degradation of neurofilament proteins." Neurotoxicology. 1993 14(1):13-8.