Fabeha Fazal, Ph.D.

Fabeha Fazal, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Office: (585) 275-9917
Fax: (585) 756-7780
Administrative: (585) 275-5948

Research Bio

A major focus of research in my laboratory deals with understanding the role and regulation of actin-myosin interactions in endothelial cell (EC) inflammation, permeability, and apoptosis, especially in the settings of acute and chronic lung injury. We study pathways of EC inflammation, barrier dysfunction and apoptosis on the molecular, cellular, and animal level.

We have uncovered novel and previously unrecognized role of actin cytoskeleton and non-muscle myosin light chain kinase (nmMLCK) in the regulation of cytoplasmic trafficking of NF-k? for its nuclear import to cause EC inflammation associate with intravascular coagulation and sepsis. More recently we have been involved in the identification of endoplasmic reticulum (ER) stress as an important determinant of EC inflammation and permeability associated with acute lung injury (ALI). In our most recent work, we have focused on understanding the role of nmMLCK in the pathogenesis of pulmonary emphysema caused by cigarette smoke (CS). The approaches ranging from biochemical, cellular, and molecular biology to in vivo gene delivery and lung physiology to study how pulmonary endothelium responds during acute and chronic lung inflammation/injury.

Awards & Honors (Local)

University Gold Medal for standing first in M.S. Examination 1987
University Gold Medal for standing first in B.S. Examination 1985

Recent Journal Articles

Showing the 5 most recent journal articles. 18 available »

2014 Dec
Bijli KM, Kanter BG, Minhajuddin M, Leonard A, Xu L, Fazal F, Rahman A. "Regulation of endothelial cell inflammation and lung polymorphonuclear lymphocyte infiltration by transglutaminase 2." Shock. 2014 Dec; 42(6):562-9.
Leonard A, Paton AW, El-Quadi M, Paton JC, Fazal F. "Preconditioning with endoplasmic reticulum stress ameliorates endothelial cell inflammation." PloS one. 2014 9(10):e110949. Epub 2014 Oct 30.
2013 Nov 1
Leonard A, Marando C, Rahman A, Fazal F. "Thrombin selectively engages LIM kinase 1 and slingshot-1L phosphatase to regulate NF-?B activation and endothelial cell inflammation." American journal of physiology. Lung cellular and molecular physiology. 2013 Nov 1; 305(9):L651-64. Epub 2013 Sep 13.
Fazal F, Bijli KM, Murrill M, Leonard A, Minhajuddin M, Anwar KN, Finkelstein JN, Watterson DM, Rahman A. "Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration." PloS one. 2013 8(3):e59965. Epub 2013 Mar 21.
2012 Nov
Bijli KM, Fazal F, Rahman A. "Regulation of Rela/p65 and endothelial cell inflammation by proline-rich tyrosine kinase 2." American journal of respiratory cell and molecular biology. 2012 Nov; 47(5):660-8. Epub 2012 Jul 27.

Current Appointments

Assistant Professor - Department of Pediatrics, Neonatology (SMD) - Primary


PhD | Biochemistry | A.M. University1992
MSc | Biochemistry | A.M. University1987
BSc | Chemistry | A.M. University1985

Post-Doctoral Training & Residency

Research Assistant Professor, Department of Pediatrics, University of Rochester, Rochester, NY 2011
Research Assistant Professor, Department of Physiology and Biophysics, University of Illinois, Chicago, IL 2003
Research Associate, Loyola University Medical Center, Maywood, IL 1998
Research Associate, Loyola University Medical Center, Maywood, IL; Advisor: Susan Baker, PhD 1995