Human-Glial Chimeric Mouse Brains for Assessment of in vivo Responses of Human Glial Cells to Injury, Inflammation, and Toxicants
United States Serial NO.: 12/015,372
Filed Date: January 16, 2008
Title: Non-Human Animals With Human-Glial Chimeric Brains
Invented by: Steven Goldman, Martha Windrem
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A Human Glial Chimeric Model for Drug Candidate Assessment in Human Gliotrophic Viral Infections and Progressive Multifocal Encephalopathy
United States Serial NO.: 14/710,144
Filed Date: May 12, 2015
Title: A Human Glial Chimeric Model for Drug Candidate Assessment in Human Gliotrophic Viral Infections and Progressive Multifocal Encephalopathy
Invented by: Steven Goldman, Yoichi Kondo, Martha Windrem, Leonid Gorelik
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Disease specific human glial mouse chimeras(HUNTINGTON'S)
United States Serial NO.: 14/701,245
Filed Date: April 30, 2015
Title: Non-Human Mammal Model of Human Degenerative Disorder, Uses Thereof, and Method for Treating Human Degenerative Disorder (HUNTINGTON'S)
Invented by: Steven Goldman, Paul Tesar, Martha Windrem, Maiken Nedergaard
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2016
Benraiss A, Wang S, Herrlinger S, Li X, Chandler-Militello D, Mauceri J, Burm HB, Toner M, Osipovitch M, Jim Xu Q, Ding F, Wang F, Kang N, Kang J, Curtin PC, Brunner D, Windrem MS, Munoz-Sanjuan I, Nedergaard M, Goldman SA. "Human glia can both induce and rescue aspects of disease phenotype in Huntington disease." Nature communications. 2016 7:11758. Epub 2016 Jun 07. |
2015 Aug
Goldman SA, Nedergaard M, Windrem MS. "Modeling cognition and disease using human glial chimeric mice." Glia. 2015 Aug; 63(8):1483-93. Epub 2015 May 24. |
2014 Nov 26
Windrem MS, Schanz SJ, Morrow C, Munir J, Chandler-Militello D, Wang S, Goldman SA. "A competitive advantage by neonatally engrafted human glial progenitors yields mice whose brains are chimeric for human glia." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Nov 26; 34(48):16153-61. |
2014
Kondo Y, Windrem MS, Zou L, Chandler-Militello D, Schanz SJ, Auvergne RM, Betstadt SJ, Harrington AR, Johnson M, Kazarov A, Gorelik L, Goldman SA. "Human glial chimeric mice reveal astrocytic dependence of JC virus infection." The Journal of clinical investigation. 2014 124(12):5323-36. Epub 2014 Nov 17. |
2012 Oct 26
Goldman SA, Nedergaard M, Windrem MS. "Glial progenitor cell-based treatment and modeling of neurological disease." Science. 2012 Oct 26; 338(6106):491-5. |
