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Irfan Rahman, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-6911

Research Labs

Biography

Research

Oxidant and cigarette smoke-mediated lung inflammation.

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is not fully reversible. It is a disabling condition associated with progressive breathlessness. COPD will account for over 6 million deaths per year in 2020 (3rd major cause of death), and move from the sixth- to the third-leading cause of death worldwide. In America, COPD affects 9% of residents aged 60 years and above and it ranked fourth in the recent morbidity survey of the elderly population. It is estimated that approximately 23.4 million people in the US have COPD and the health burden is $36.1 billions per year. At present, there is no effective treatment exists to halt the decline in lung function in response to smoking. This in turn reflects a lack of understanding of the specific cellular and molecular pathways triggered in the lung by tobacco smoke/oxidants.

Our laboratory is interested in understanding the redox signaling, mechanism of proinflammatory gene expression by studying the chromatin remodeling-epigenetic changes (histone acetylation/deacetylation) on pro-inflammatory genes, involvement of anti-inflammatory and anti-aging proteins sirtuins, and steroid resistance in chronic inflammatory diseases/COPD. Recent research includes in understanding the role of sirtuins in aging and accelerated decline in lung function and regulation of circadian genes. Our long-term goal is to understand the cellular and molecular mechanisms involved in pathogenesis of COPD, and the potential benefit of therapeutic interventions in this debilitating disease.

Credentials

Faculty Appointments

Education

0-0
PhD |
Biochemistry

0-0
MS |
Biochemistry

0-0
BS |
Biology and Chemistry

Awards

2006
Senior Investigator Award: The Oxygen Club of California

Publications

Journal Articles

12/9/2017
Javed F, Kellesarian SV, Abduljabbar T, Abduljabbar AT, Akram Z, Vohra F, Rahman I, Romanos GE. "Influence of involuntary cigarette smoke inhalation on osseointegration: a systematic review and meta-analysis of preclinical studies." International journal of oral and maxillofacial surgery.. 2017 Dec 9; Epub 2017 Dec 09.

12/9/2017
Tang M, Ji C, Pallo S, Rahman I, Johnson GVW. "Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner." Neurobiology of aging.. 2017 Dec 9; 63:128-139. Epub 2017 Dec 09.

11/2017
Javed F, Kellesarian SV, Sundar IK, Romanos GE, Rahman I. "Recent updates on electronic cigarette aerosol and inhaled nicotine effects on periodontal and pulmonary tissues." Oral diseases.. 2017 Nov 0; 23(8):1052-1057. Epub 2017 Mar 30.

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