Toru Takimoto, D.V.M., Ph.D.

Toru Takimoto, D.V.M., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 672
Rochester, NY 14642

Office: (585) 273-2856
Lab: (585) 273-2894
Fax: (585) 473-9573

Journal Articles

Showing all 61 journal articles available.

2016 Aug 15
Hayashi T, Chaimayo C, McGuinness J, Takimoto T. "Critical Role of the PA-X C-Terminal Domain of Influenza A Virus in Its Subcellular Localization and Shutoff Activity." Journal of virology. 2016 Aug 15; 90(16):7131-41. Epub 2016 Jul 27.
2016 Jan
Stone R, Hayashi T, Bajimaya S, Hodges E, Takimoto T. "Critical role of Rab11a-mediated recycling endosomes in the assembly of type I parainfluenza viruses." Virology. 2016 Jan; 487:11-8. Epub 2015 Oct 17.
2015 Aug 14
Hayashi T, Chaimayo C, Takimoto T. "Impact of influenza PA-X on host response." Oncotarget. 2015 Aug 14; 6(23):19364-5.
2015 Aug
Hayashi T, Wills S, Bussey KA, Takimoto T. "Identification of Influenza A Virus PB2 Residues Involved in Enhanced Polymerase Activity and Virus Growth in Mammalian Cells at Low Temperatures." Journal of virology. 2015 Aug; 89(15):8042-9. Epub 2015 May 27.
2015 Jun
Hayashi T, MacDonald LA, Takimoto T. "Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune Responses." Journal of virology. 2015 Jun; 89(12):6442-52. Epub 2015 Apr 08.
2015 May 8
Fukushima K, Takahashi T, Ueyama H, Takaguchi M, Ito S, Oishi K, Minami A, Ishitsubo E, Tokiwa H, Takimoto T, Suzuki T. "Amino acid substitutions contributing to ?2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase." FEBS letters. 2015 May 8; 589(11):1278-82. Epub 2015 Apr 11.
2015 May
Zhan X, Slobod KS, Jones BG, Sealy RE, Takimoto T, Boyd K, Surman S, Russell CJ, Portner A, Hurwitz JL. "Sendai virus recombinant vaccine expressing a secreted, unconstrained respiratory syncytial virus fusion protein protects against RSV in cotton rats." International immunology. 2015 May; 27(5):229-36. Epub 2014 Dec 04.
2014 Feb
Bialas KM, Bussey KA, Stone RL, Takimoto T. "Specific nucleoprotein residues affect influenza virus morphology." Journal of virology. 2014 Feb; 88(4):2227-34. Epub 2013 Dec 11.
2013 Mar
Desmet EA, Bussey KA, Stone R, Takimoto T. "Identification of the N-terminal domain of the influenza virus PA responsible for the suppression of host protein synthesis." Journal of virology. 2013 Mar; 87(6):3108-18. Epub 2013 Jan 02.
Stone R, Takimoto T. "Critical role of the fusion protein cytoplasmic tail sequence in parainfluenza virus assembly." PloS one. 2013 8(4):e61281. Epub 2013 Apr 12.
2012 May
Noronha JM, Liu M, Squires RB, Pickett BE, Hale BG, Air GM, Galloway SE, Takimoto T, Schmolke M, Hunt V, Klem E, García-Sastre A, McGee M, Scheuermann RH. "Influenza virus sequence feature variant type analysis: evidence of a role for NS1 in influenza virus host range restriction." Journal of virology. 2012 May; 86(10):5857-66. Epub 2012 Mar 07.
2012 Apr 25
MacDonald LA, Aggarwal S, Bussey KA, Desmet EA, Kim B, Takimoto T. "Molecular interactions and trafficking of influenza A virus polymerase proteins analyzed by specific monoclonal antibodies." Virology. 2012 Apr 25; 426(1):51-9. Epub 2012 Feb 08.
2012 Jan 20
Jones BG, Sealy R, Rudraraju R, Traina-Dorge V, Finneyfrock B, Cook A, Takimoto T, Portner A, Hurwitz JL. "Sendai virus-based RSV vaccine protects African green monkeys from RSV infection." Vaccine. 2012 Jan 20; 30(5):959-68. Epub 2011 Nov 23.
Bialas KM, Desmet EA, Takimoto T. "Specific residues in the 2009 H1N1 swine-origin influenza matrix protein influence virion morphology and efficiency of viral spread in vitro." PloS one. 2012 7(11):e50595. Epub 2012 Nov 27.
2011 Oct 7
Aggarwal S, Dewhurst S, Takimoto T, Kim B. "Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex." The Journal of biological chemistry. 2011 Oct 7; 286(40):34504-13. Epub 2011 Aug 04.
2011 Jul 1
Noble E, Mathews DH, Chen JL, Turner DH, Takimoto T, Kim B. "Biophysical analysis of influenza A virus RNA promoter at physiological temperatures." The Journal of biological chemistry. 2011 Jul 1; 286(26):22965-70. Epub 2011 May 09.
2011 Jul
Bussey KA, Desmet EA, Mattiacio JL, Hamilton A, Bradel-Tretheway B, Bussey HE, Kim B, Dewhurst S, Takimoto T. "PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells." Journal of virology. 2011 Jul; 85(14):7020-8. Epub 2011 May 11.
2011 Jan
Guo H, Santiago F, Lambert K, Takimoto T, Topham DJ. "T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model." Journal of virology. 2011 Jan; 85(1):448-55. Epub 2010 Oct 27.
2010 Jun 7
Chambers R, Takimoto T. "Trafficking of Sendai virus nucleocapsids is mediated by intracellular vesicles." PloS one. 2010 Jun 7; 5(6):e10994. Epub 2010 Jun 07.
2010 May 10
Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB. "Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells." Virology. 2010 May 10; 400(2):224-32. Epub 2010 Feb 25.
2010 May
Bussey KA, Bousse TL, Desmet EA, Kim B, Takimoto T. "PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells." Journal of virology. 2010 May; 84(9):4395-406. Epub 2010 Feb 24.
2010 Apr 29
Aggarwal S, Bradel-Tretheway B, Takimoto T, Dewhurst S, Kim B. "Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex." PloS one. 2010 Apr 29; 5(4):e10372. Epub 2010 Apr 29.
2009 Dec
Chambers R, Takimoto T. "Antagonism of innate immunity by paramyxovirus accessory proteins." Viruses. 2009 Dec; 1(3):574-93. Epub 2009 Oct 28.
2009 Aug
Chambers R, Takimoto T. "Host specificity of the anti-interferon and anti-apoptosis activities of parainfluenza virus P/C gene products." The Journal of general virology. 2009 Aug; 90(Pt 8):1906-15. Epub 2009 May 07.
2008 Dec
Bradel-Tretheway BG, Kelley Z, Chakraborty-Sett S, Takimoto T, Kim B, Dewhurst S. "The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit." The Journal of general virology. 2008 Dec; 89(Pt 12):2923-32.
2008 Jun 25
Zhan X, Slobod KS, Krishnamurthy S, Luque LE, Takimoto T, Jones B, Surman S, Russell CJ, Portner A, Hurwitz JL. "Sendai virus recombinant vaccine expressing hPIV-3 HN or F elicits protective immunity and combines with a second recombinant to prevent hPIV-1, hPIV-3 and RSV infections." Vaccine. 2008 Jun 25; 26(27-28):3480-8. Epub 2008 May 01.
2007 Dec 17
Zhan X, Hurwitz JL, Krishnamurthy S, Takimoto T, Boyd K, Scroggs RA, Surman S, Portner A, Slobod KS. "Respiratory syncytial virus (RSV) fusion protein expressed by recombinant Sendai virus elicits B-cell and T-cell responses in cotton rats and confers protection against RSV subtypes A and B." Vaccine. 2007 Dec 17; 25(52):8782-93. Epub 2007 Nov 05.
2007 Nov
Brown SA, Hurwitz JL, Zirkel A, Surman S, Takimoto T, Alymova I, Coleclough C, Portner A, Doherty PC, Slobod KS. "A recombinant Sendai virus is controlled by CD4+ effector T cells responding to a secreted human immunodeficiency virus type 1 envelope glycoprotein." Journal of virology. 2007 Nov; 81(22):12535-42. Epub 2007 Jul 25.
2006 Oct
Bousse T, Chambers RL, Scroggs RA, Portner A, Takimoto T. "Human parainfluenza virus type 1 but not Sendai virus replicates in human respiratory cells despite IFN treatment." Virus research. 2006 Oct; 121(1):23-32. Epub 2006 May 03.
2006 Sep
Bousse T, Takimoto T. "Mutation at residue 523 creates a second receptor binding site on human parainfluenza virus type 1 hemagglutinin-neuraminidase protein." Journal of virology. 2006 Sep; 80(18):9009-16.
2006 Jun
Krishnamurthy S, Takimoto T, Scroggs RA, Portner A. "Differentially regulated interferon response determines the outcome of Newcastle disease virus infection in normal and tumor cell lines." Journal of virology. 2006 Jun; 80(11):5145-55.
2005 Jan
Alymova IV, Portner A, Takimoto T, Boyd KL, Babu YS, McCullers JA. "The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae." Antimicrobial agents and chemotherapy. 2005 Jan; 49(1):398-405.
Takimoto T, Hurwitz JL, Zhan X, Krishnamurthy S, Prouser C, Brown B, Coleclough C, Boyd K, Scroggs RA, Portner A, Slobod KS. "Recombinant Sendai virus as a novel vaccine candidate for respiratory syncytial virus." Viral immunology. 2005 18(2):255-66.
2004 Dec
Bousse TL, Taylor G, Krishnamurthy S, Portner A, Samal SK, Takimoto T. "Biological significance of the second receptor binding site of Newcastle disease virus hemagglutinin-neuraminidase protein." Journal of virology. 2004 Dec; 78(23):13351-5.
2004 Dec
Takimoto T, Portner A. "Molecular mechanism of paramyxovirus budding." Virus research. 2004 Dec; 106(2):133-45.
2004 Jun
Takimoto T, Hurwitz JL, Coleclough C, Prouser C, Krishnamurthy S, Zhan X, Boyd K, Scroggs RA, Brown B, Nagai Y, Portner A, Slobod KS. "Recombinant Sendai virus expressing the G glycoprotein of respiratory syncytial virus (RSV) elicits immune protection against RSV." Journal of virology. 2004 Jun; 78(11):6043-7.
2004 May
Alymova IV, Taylor G, Takimoto T, Lin TH, Chand P, Babu YS, Li C, Xiong X, Portner A. "Efficacy of novel hemagglutinin-neuraminidase inhibitors BCX 2798 and BCX 2855 against human parainfluenza viruses in vitro and in vivo." Antimicrobial agents and chemotherapy. 2004 May; 48(5):1495-502.
2004 Apr
Zaitsev V, von Itzstein M, Groves D, Kiefel M, Takimoto T, Portner A, Taylor G. "Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion." Journal of virology. 2004 Apr; 78(7):3733-41.
2002 Dec
Takimoto T, Taylor GL, Connaris HC, Crennell SJ, Portner A. "Role of the hemagglutinin-neuraminidase protein in the mechanism of paramyxovirus-cell membrane fusion." Journal of virology. 2002 Dec; 76(24):13028-33.
2002 Aug
Bousse T, Matrosovich T, Portner A, Kato A, Nagai Y, Takimoto T. "The long noncoding region of the human parainfluenza virus type 1 f gene contributes to the read-through transcription at the m-f gene junction." Journal of virology. 2002 Aug; 76(16):8244-51.
2002 Feb
Connaris H, Takimoto T, Russell R, Crennell S, Moustafa I, Portner A, Taylor G. "Probing the sialic acid binding site of the hemagglutinin-neuraminidase of Newcastle disease virus: identification of key amino acids involved in cell binding, catalysis, and fusion." Journal of virology. 2002 Feb; 76(4):1816-24.
2001 Dec
Takimoto T, Murti KG, Bousse T, Scroggs RA, Portner A. "Role of matrix and fusion proteins in budding of Sendai virus." Journal of virology. 2001 Dec; 75(23):11384-91.
2001 May 10
Bousse T, Takimoto T, Matrosovich T, Portner A. "Two regions of the P protein are required to be active with the L protein for human parainfluenza virus type 1 RNA polymerase activity." Virology. 2001 May 10; 283(2):306-14.
2001 May
Suzuki T, Portner A, Scroggs RA, Uchikawa M, Koyama N, Matsuo K, Suzuki Y, Takimoto T. "Receptor specificities of human respiroviruses." Journal of virology. 2001 May; 75(10):4604-13.
2001 Feb
Coronel EC, Takimoto T, Murti KG, Varich N, Portner A. "Nucleocapsid incorporation into parainfluenza virus is regulated by specific interaction with matrix protein." Journal of virology. 2001 Feb; 75(3):1117-23.
2000 Nov
Crennell S, Takimoto T, Portner A, Taylor G. "Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase." Nature structural biology. 2000 Nov; 7(11):1068-74.
2000 Sep
Takimoto T, Bousse T, Portner A. "Molecular cloning and expression of human parainfluenza virus type 1 L gene." Virus research. 2000 Sep; 70(1-2):45-53.
2000 Apr 25
Takimoto T, Taylor GL, Crennell SJ, Scroggs RA, Portner A. "Crystallization of Newcastle disease virus hemagglutinin-neuraminidase glycoprotein." Virology. 2000 Apr 25; 270(1):208-14.
1999 Nov 12
Chen Y, Takimoto T, Liu L, Surman S, Woodland DL. "DNA vaccination as a tool to identify subdominant CD8 T cell epitopes." Vaccine. 1999 Nov 12; 18(7-8):720-7.
1999 Aug
Coronel EC, Murti KG, Takimoto T, Portner A. "Human parainfluenza virus type 1 matrix and nucleoprotein genes transiently expressed in mammalian cells induce the release of virus-like particles containing nucleocapsid-like structures." Journal of virology. 1999 Aug; 73(8):7035-8.
1998 Dec
Takimoto T, Bousse T, Coronel EC, Scroggs RA, Portner A. "Cytoplasmic domain of Sendai virus HN protein contains a specific sequence required for its incorporation into virions." Journal of virology. 1998 Dec; 72(12):9747-54.
1997 May 26
Bousse T, Takimoto T, Murti KG, Portner A. "Elevated expression of the human parainfluenza virus type 1 F gene downregulates HN expression." Virology. 1997 May 26; 232(1):44-52.
1995 Jun 1
Bousse T, Takimoto T, Portner A. "A single amino acid changes enhances the fusion promotion activity of human parainfluenza virus type 1 hemagglutinin-neuraminidase glycoprotein." Virology. 1995 Jun 1; 209(2):654-7.
1994 Nov 1
Bousse T, Takimoto T, Gorman WL, Takahashi T, Portner A. "Regions on the hemagglutinin-neuraminidase proteins of human parainfluenza virus type-1 and Sendai virus important for membrane fusion." Virology. 1994 Nov 1; 204(2):506-14.
1994 Oct
Hyland L, Hou S, Coleclough C, Takimoto T, Doherty PC. "Mice lacking CD8+ T cells develop greater numbers of IgA-producing cells in response to a respiratory virus infection." Virology. 1994 Oct; 204(1):234-41.
1994 Apr
Takimoto T, Portner A. "The human parainfluenza virus type-1 prototypic strain contains a heat-labile hemagglutinin-neuraminidase protein." Virus research. 1994 Apr; 32(1):85-92.
1994 Mar
Dave VP, Allan JE, Slobod KS, Smith FS, Ryan KW, Takimoto T, Power UF, Portner A, Hurwitz JL. "Viral cross-reactivity and antigenic determinants recognized by human parainfluenza virus type 1-specific cytotoxic T-cells." Virology. 1994 Mar; 199(2):376-83.
1993 Feb 15
Murti KG, Takimoto T, Laver WG, Portner A. "Crystals of hemagglutinin-neuraminidase of parainfluenza virus contain triple-stranded helices." Proceedings of the National Academy of Sciences of the United States of America. 1993 Feb 15; 90(4):1523-5.
1992 Dec
Takimoto T, Laver WG, Murti KG, Portner A. "Crystallization of biologically active hemagglutinin-neuraminidase glycoprotein dimers proteolytically cleaved from human parainfluenza virus type 1." Journal of virology. 1992 Dec; 66(12):7597-600.
1988 Jul
Ito T, Takimoto T, Yanagawa R. "Presence of a variety of antigenic variants belonging to at least 4 different serovars in a population of Leptospira interrogans serovar hebdomadis." Zentralblatt für Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology. 1988 Jul; 269(1):15-25.
Takimoto T, Ono E, Ito T, Yanagawa R. "Affinity constants of anti-leptospira monoclonal antibodies, numbers of antigenic determinants on leptospiras, and their influence on the microscopic agglutination test and ELISA." Microbiology and immunology. 1988 32(8):775-84.


Takimoto T. "Parainfluenza viruses. (version 2.0) Encyclopedia of Life Sciences. John Wiley & Sons, Ltd. 2006.". Encyclopedia of Life Sciences. : John Wiley & Sons, Ltd., 2006.
Takimoto T.. "Parainfluenza viruses. Nature Encyclopedia of Life Science. Nature Publishing Group. 2002.". Nature Encyclopedia of Life Science. : Nature Publishing Group, 2002.