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Toru Takimoto, D.V.M., Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-2856

Fax: (585) 473-9573

Research Labs

Lab: (585) 273-2894

Visit Lab Website

Biography

Research

RESEARCH ACTIVITIES

Research project in progress
The major areas of research in my laboratory are as follows:
Molecular mechanism of paramyxovirus assembly: Efficient assembly and release of progeny virions from infected cells are major determinants of viral pathogenicity. Molecular mechanism of paramyxovirus assembly is not well understood. We are characterizing the trafficking of viral nucleocapsid to the site of assembly at the plasma membrane to understand the cellular machinery viruses utilize for assembly of progeny virions. URSMD Collaborators = Brian Ward, Minsoo Kim.

Assembly of Influenza A viruses: Influenza viruses replicate and form nucleocapsid core in nuclei of infected cells. The progeny nucleocapsid cores are then transported to the plasma membrane budding sites. This study analyzes cellular and viral protein interactions required for the nuclear export of nucleocapsid and budding of progeny virions. URSMD Collaborators = Brian Ward

Role of Influenza Virus Polymerase in Host Adaptation: We participate in the virology research team of the New York Influenza Center of Excellence (NYICE), which is part of the NIH Centers of Excellence for Influenza Research and Surveillance (CEIRS) network. Our focus is on the influenza virus RNA polymerase, and understanding how it contributes to host adaptation. We characterize the polymerase activities of avian and human strains, and identify residues and subunits of the polymerase complex important for the enhanced activity in mammalian hosts in vitro and in vivo. URSMD Collaborators = David Topham, John Treanor, Steve Dewhurst, Baek Kim.

Credentials

Faculty Appointments

Education

1986
BS | Japan-Hokkaido University - Sapporo
Veterinary Medicine

1988
MS | Japan-Hokkaido University - Sapporo
Microbiology

1989
DVM | Japan-Hokkaido University - Sapporo
Veterinary Medicine

1994
PhD | Japan-Hokkaido University - Sapporo
Microbiology

Publications

Journal Articles

10/2017
Bajimaya S, Frankl T, Hayashi T, Takimoto T. "Cholesterol is required for stability and infectivity of influenza A and respiratory syncytial viruses." Virology.. 2017 Oct 0; 510:234-241. Epub 2017 Jul 25.

9/2017
Russell CJ, Jones BG, Sealy RE, Surman SL, Mason JN, Hayden RT, Tripp RA, Takimoto T, Hurwitz JL. "A Sendai virus recombinant vaccine expressing a gene for truncated human metapneumovirus (hMPV) fusion protein protects cotton rats from hMPV challenge." Virology.. 2017 Sep 0; 509:60-66. Epub 2017 Jun 09.

5/2017
Chaimayo C, Hayashi T, Underwood A, Hodges E, Takimoto T. "Selective incorporation of vRNP into influenza A virions determined by its specific interaction with M1 protein." Virology.. 2017 May 0; 505:23-32. Epub 2017 Feb 17.

Books & Chapters

2006
Chapter Title: Parainfluenza viruses. (version 2.0) Encyclopedia of Life Sciences. John Wiley & Sons, Ltd. 2006.
Book Title: Encyclopedia of Life Sciences
Author List: Takimoto T
Published By: John Wiley & Sons, Ltd.2006

2002
Chapter Title: Parainfluenza viruses. Nature Encyclopedia of Life Science. Nature Publishing Group. 2002.
Book Title: Nature Encyclopedia of Life Science
Author List: Takimoto T.
Published By: Nature Publishing Group2002

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