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Toru Takimoto, D.V.M., Ph.D.

Contact Information

Phone Numbers

Fax: (585) 473-9573

Office: (585) 273-2856

Research Labs



RESEARCH ACTIVITIES Research project in progress The major areas of research in my laboratory are as follows: Molecular mechanism of paramyxovirus assembly: Efficient assembly and release of progeny virions from infected cells are major determinants of viral pathogenicity. Molecular mechanism of paramyxovirus assembly is not well understood. We are characterizing the trafficking of viral nucleocapsid to the site of assembly at the plasma membrane to understand the cellular machinery viruses utilize for assembly of progeny virions. URSMD Collaborators = Brian Ward, Minsoo Kim. Assembly of Influenza A viruses: Influenza viruses replicate and form nucleocapsid core in nuclei of infected cells. The progeny nucleocapsid cores are then transported to the plasma membrane budding sites. This study analyzes cellular and viral protein interactions required for the nuclear export of nucleocapsid and budding of progeny virions. URSMD Collaborators = Brian Ward Role of Influenza Virus Polymerase in Host Adaptation: We participate in the virology research team of the New York Influenza Center of Excellence (NYICE), which is part of the NIH Centers of Excellence for Influenza Research and Surveillance (CEIRS) network. Our focus is on the influenza virus RNA polymerase, and understanding how it contributes to host adaptation. We characterize the polymerase activities of avian and human strains, and identify residues and subunits of the polymerase complex important for the enhanced activity in mammalian hosts in vitro and in vivo. URSMD Collaborators = David Topham, John Treanor, Steve Dewhurst, Baek Kim.


Faculty Appointments


DVM | Japan-Hokkaido University - Sapporo
Veterinary Medicine

BS | Japan-Hokkaido University - Sapporo
Veterinary Medicine

PhD | Japan-Hokkaido University - Sapporo

MS | Japan-Hokkaido University - Sapporo


Journal Articles

Chaimayo C, Hayashi T, Underwood A, Hodges E, Takimoto T. "Selective incorporation of vRNP into influenza A virions determined by its specific interaction with M1 protein." Virology.. 2017 May 0; 505:23-32. Epub 2017 Feb 17.

Bajimaya S, Hayashi T, Frankl T, Bryk P, Ward B, Takimoto T. "Cholesterol reducing agents inhibit assembly of type I parainfluenza viruses." Virology.. 2017 Jan 15; 501:127-135. Epub 2016 Dec 02.

Hayashi T, Chaimayo C, McGuinness J, Takimoto T. "Critical Role of the PA-X C-Terminal Domain of Influenza A Virus in Its Subcellular Localization and Shutoff Activity." Journal of virology.. 2016 Aug 15; 90(16):7131-41. Epub 2016 Jul 27.

Books & Chapters

Chapter Title: Parainfluenza viruses. (version 2.0) Encyclopedia of Life Sciences. John Wiley & Sons, Ltd. 2006.
Book Title: Encyclopedia of Life Sciences
Author List: Takimoto T
Published By: John Wiley & Sons, Ltd.2006

Chapter Title: Parainfluenza viruses. Nature Encyclopedia of Life Science. Nature Publishing Group. 2002.
Book Title: Nature Encyclopedia of Life Science
Author List: Takimoto T.
Published By: Nature Publishing Group2002