Professional Bio
Dr. Sally A. Quataert, Director of the Human Immunology Center (HIC) Core Laboratory, is an internationally recognized expert in bioanalytical method development and standardization. She received her Ph.D. in Microbiology from the State University of New York at Buffalo and has over 25 years in the pharmaceutical and medical device fields. Under her leadership and scientific direction, her laboratory at Wyeth Vaccines (formerly Lederle-Praxis Biologicals) established W.H.O. recognized methods for evaluating serological correlates for immune protection with polysaccharide conjugate vaccines for Neisseria meningitis, Haemophilus influenzae, and Streptococcus pneumoniae.
Dr. Quataert has extensive experience in conducting inter-laboratory studies and method validation in support of pre-clinical and clinical testing. She was responsible for all aspects of laboratory regulatory compliance and quality systems management in the performance of clinical trial evaluations for vaccine development at Wyeth. Prior to joining Wyeth, Dr. Quataert worked for Electro-Nucleonics, Inc. and Corning Glass Works in the development of immunodiagnostic tests and monoclonal antibody reagents for the biomedical field. Early in her career, Dr. Quataert's interest focused in developing methods for the evaluation of human immune responses in the field of tumor immunology. Her goals for the HIC Core lab are to reduce to practise the highest quality innovative bioanalytical techniques for evaluation of human immune responses and to assist biomedical researchers in the acquisition and execution of these techniques.
Research Bio
The mission of the Human Immunology Center is to provide expertise for applying new cutting edge immunological techniques from basic animal research through development and standardization to human research. Research in the HIC core laboratory supports exploratory clinical research programs by establishing measures for immune status and response across multiple disciplines and programs.
Standard procedures using 18-color multichromatic flow cytometry for cell analysis and 15-color cell sorting, Elispot, fluorispot and lysispot are available for application to clinical trials including lymphoma, autoimmunity, and infectious disease.
New techniques provide insight into T, B, dendritic and antigen presenting cell regulation, activation and interactions. Standardized reagent panels for human cell differentiation and activation markers provide the consistency needed to allow interpretation of complex data from analysis of human immune compartments
2009
Kyu,S. Y.; Kobie,J.; Yang,H.; Zand,M. S.; Topham,D. J.; Quataert,S. A.; Sanz,I.; Lee,F. E.;. "Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells". J.Immunol.Methods. 2009; 340(1): 42-47. Link |
2008
Wang,J. C.; Kobie,J. J.; Zhang,L.; Cochran,M.; Mosmann,T. R.; Ritchlin,C. T.; Quataert,S. A.;. "An 11-color flow cytometric assay for identifying, phenotyping, and assessing endocytic ability of peripheral blood dendritic cell subsets in a single platform". J.Immunol.Methods. 2008; . Link |
2005
Hu,B. T.; Yu,X.; Jones,T. R.; Kirch,C.; Harris,S.; Hildreth,S. W.; Madore,D. V.; Quataert,S. A.;. "Approach to validating an opsonophagocytic assay for Streptococcus pneumoniae". Clin.Diagn.Lab.Immunol.. 2005; 12(2): 287-295. Link |
2005
Sikkema,D. J.; Ziembiec,N. A.; Jones,T. R.; Hildreth,S. W.; Madore,D. V.; Quataert,S. A.;. "Assignment of weight-based immunoglobulin G1 (IgG1) and IgG2 units in antipneumococcal reference serum lot 89-S(F) for pneumococcal polysaccharide serotypes 1, 4, 5, 7F, 9V, and 18C". Clin.Diagn.Lab.Immunol.. 2005; 12(1): 218-223. Link |
2004
Quataert,S. A.; Rittenhouse-Olson,K.; Kirch,C. S.; Hu,B.; Secor,S.; Strong,N.; Madore,D. V.;. "Assignment of weight-based antibody units for 13 serotypes to a human antipneumococcal standard reference serum, lot 89-S(f)". Clin.Diagn.Lab.Immunol.. 2004; 11(6): 1064-1069. Link |
