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Damian J. Krysan, M.D., Ph.D.

Pediatrics

Publications

Showing all 61 journal articles & 2 books available

Journal Articles

2/17/2017
Krysan DJ. "The unmet clinical need of novel antifungal drugs." Virulence.. 2017 Feb 17; 8(2):135-137.

12/2016
Koselny K, Green J, DiDone L, Halterman JP, Fothergill AW, Wiederhold NP, Patterson TF, Cushion MT, Rappelye C, Wellington M, Krysan DJ. "The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis." Antimicrobial agents and chemotherapy.. 2016 Dec 0; 60(12):7115-7127. Epub 2016 Nov 21.

8/2016
Krysan DJ. "Challenges in the development of novel anticryptococcal agents." Future medicinal chemistry.. 2016 Aug 0; 8(12):1375-7. Epub 2016 Aug 03.

7/2016
Saputo S, Norman KL, Murante T, Horton BN, De La Cruz Diaz J, DiDone L, Colquhoun J, Schroeder JW, Simmons LA, Kumar A, Krysan DJ. "Complex Haploinsufficiency-Based Genetic Analysis of the NDR/Lats Kinase Cbk1 Provides Insight into Its Multiple Functions in Candida albicans." Genetics.. 2016 Jul 0; 203(3):1217-33. Epub 2016 May 20.

4/8/2016
Koselny K, Green J, Favazzo L, Glazier VE, DiDone L, Ransford S, Krysan DJ. "Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase." ACS infectious diseases.. 2016 Apr 8; 2(4):268-280. Epub 2016 Feb 23.

1/8/2016
Hartland K, Pu J, Palmer M, Dandapani S, Moquist PN, Munoz B, DiDone L, Schreiber SL, Krysan DJ. "High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling." ACS infectious diseases.. 2016 Jan 8; 2(1):93-102. Epub 2015 Nov 06.

5/2015
Krysan DJ. "Toward improved anti-cryptococcal drugs: Novel molecules and repurposed drugs." Fungal genetics and biology : FG & B.. 2015 May 0; 78:93-8. Epub 2014 Dec 13.

2015
Butts A, Martin JA, DiDone L, Bradley EK, Mutz M, Krysan DJ. "Structure-activity relationships for the antifungal activity of selective estrogen receptor antagonists related to tamoxifen." PloS one. 2015 10(5):e0125927. Epub 2015 May 27.

2015
Forbes L, Ebsworth-Mojica K, DiDone L, Li SG, Freundlich JS, Connell N, Dunman PM, Krysan DJ. "A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis." PloS one. 2015 10(6):e0129234. Epub 2015 Jun 22.

11/20/2014
Brown JC, Nelson J, VanderSluis B, Deshpande R, Butts A, Kagan S, Polacheck I, Krysan DJ, Myers CL, Madhani HD. "Unraveling the biology of a fungal meningitis pathogen using chemical genetics." Cell.. 2014 Nov 20; 159(5):1168-87.

10/23/2014
Perlmutter JI, Forbes LT, Krysan DJ, Ebsworth-Mojica K, Colquhoun JM, Wang JL, Dunman PM, Flaherty DP. "Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus." Journal of medicinal chemistry.. 2014 Oct 23; 57(20):8540-62. Epub 2014 Oct 06.

9/2014
Saputo S, Kumar A, Krysan DJ. "Efg1 directly regulates ACE2 expression to mediate cross talk between the cAMP/PKA and RAM pathways during Candida albicans morphogenesis." Eukaryotic cell.. 2014 Sep 0; 13(9):1169-80. Epub 2014 Jul 07.

9/2014
Hoy Z, Dodds Ashley ES, Weinberg GA, Krysan DJ. "Voriconazole Therapeutic Drug Monitoring." Journal of the Pediatric Infectious Diseases Society.. 2014 Sep 0; 3(3):270-1. Epub 2014 Mar 30.

6/2014
Krysan DJ, Sutterwala FS, Wellington M. "Catching fire: Candida albicans, macrophages, and pyroptosis." PLoS pathogens.. 2014 Jun 0; 10(6):e1004139. Epub 2014 Jun 26.

5/1/2014
Roemer T, Krysan DJ. "Antifungal drug development: challenges, unmet clinical needs, and new approaches." Cold Spring Harbor perspectives in medicine. 2014 May 1; 4(5)Epub 2014 May 01.

5/2014
Falsetta ML, Klein MI, Colonne PM, Scott-Anne K, Gregoire S, Pai CH, Gonzalez M, Watson G, Krysan DJ, Bowen WH, Koo H. "Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo." Infection and immunity.. 2014 May 0; 82(5):1968-81. Epub 2014 Feb 24.

2/11/2014
Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, Didone L, Tabroff J, Childers WE, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ. "Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo." mBio. 2014 Feb 11; 5(1):e00765-13. Epub 2014 Feb 11.

2/2014
Wellington M, Koselny K, Sutterwala FS, Krysan DJ. "Candida albicans triggers NLRP3-mediated pyroptosis in macrophages." Eukaryotic cell.. 2014 Feb 0; 13(2):329-40. Epub 2013 Dec 27.

2/2013
Butts A, Didone L, Koselny K, Baxter BK, Chabrier-Rosello Y, Wellington M, Krysan DJ. "A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis." Eukaryotic cell.. 2013 Feb 0; 12(2):278-87. Epub 2012 Dec 14.

1/2013
Chabrier-Roselló Y, Gerik KJ, Koselny K, Didone L, Lodge JK, Krysan DJ. "Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes." Eukaryotic cell.. 2013 Jan 0; 12(1):12-22. Epub 2012 Oct 19.

12/26/2012
Wellington M, Koselny K, Krysan DJ. "Candida albicans morphogenesis is not required for macrophage interleukin 1? production." mBio. 2012 Dec 26; 4(1):e00433-12. Epub 2012 Dec 26.

9/2012
Butts A, Krysan DJ. "Antifungal drug discovery: something old and something new." PLoS pathogens.. 2012 Sep 0; 8(9):e1002870. Epub 2012 Sep 06.

6/2012
Saputo S, Chabrier-Rosello Y, Luca FC, Kumar A, Krysan DJ. "The RAM network in pathogenic fungi." Eukaryotic cell.. 2012 Jun 0; 11(6):708-17. Epub 2012 Apr 27.

8/2011
Didone L, Oga D, Krysan DJ. "A novel assay of biofilm antifungal activity reveals that amphotericin B and caspofungin lyse Candida albicans cells in biofilms." Yeast (Chichester, England). 2011 Aug 0; 28(8):561-8. Epub 2011 Jun 15.

5/20/2011
Baxter BK, Didone L, Oga D, Schor S, Krysan DJ. "Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules." ACS chemical biology. 2011 May 20; 6(5):502-10. Epub 2011 Feb 22.

4/2011
Bharucha N, Chabrier-Roselló Y, Xu T, Johnson C, Sobczynski S, Song Q, Dobry CJ, Eckwahl MJ, Anderson CP, Benjamin AJ, Kumar A, Krysan DJ. "A Large-Scale Complex Haploinsufficiency-Based Genetic Interaction Screen in Candida albicans: Analysis of the RAM Network during Morphogenesis." PLoS genetics.. 2011 Apr 0; 7(4):e1002058. Epub 2011 Apr 28.

4/2011
Bharucha N, Chabrier-Rosello Y, Xu T, Johnson C, Sobczynski S, Song Q, Dobry CJ, Eckwah MJ, Anderson CP, Benjamin AJ, Kumar A, Krysan DJ. "A large-scale complex haploinsufficiency-based genetic interaction screen in Candida albicans: analysis of the RAM network during morphogenesis." PLoS genetics.. 2011 Apr 0; 7(4):e1002058.

3/2011
Kainth MK, Krysan DJ. "Age and symptoms affect the prevalence of group A beta-hemolytic streptococcus in pharyngeal cultures of school-age children." The Journal of pediatrics.. 2011 Mar 0; 158(3):515-6.

11/2010
Miller KA, Didone L, Krysan DJ. "Extracellular secretion of overexpressed glycosylphosphatidylinositol-linked cell wall protein Utr2/Crh2p as a novel protein quality control mechanism in Saccharomyces cerevisiae." Eukaryotic cell.. 2010 Nov 0; 9(11):1669-79. Epub 2010 Sep 10.

6/2010
Didone L, Scrimale T, Baxter BK, Krysan DJ. "A high-throughput assay of yeast cell lysis for drug discovery and genetic analysis." Nature protocols. 2010 Jun 0; 5(6):1107-14. Epub 2010 May 27.

8/2009
Dolan K, Montgomery S, Bucchiet B, Didone L, Wellington M, Krysan DJ. "Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization." Antimicrobial agents and chemotherapy.. 2009 Aug 0; 53(8):3337-46. Epub 2009 Jun 01.

5/2009
Krysan DJ. "The cell wall and endoplasmic reticulum stress responses are coordinately regulated in Saccharomyces cerevisiae." Communicative & integrative biology. 2009 May 0; 2(3):233-5.

1/2009
Scrimale T, Didone L, de Mesy Bentley KL, Krysan DJ. "The unfolded protein response is induced by the cell wall integrity mitogen-activated protein kinase signaling cascade and is required for cell wall integrity in Saccharomyces cerevisiae." Molecular biology of the cell.. 2009 Jan 0; 20(1):164-75. Epub 2008 Oct 29.

1/2009
Wellington M, Dolan K, Krysan DJ. "Live Candida albicans suppresses production of reactive oxygen species in phagocytes." Infection and immunity.. 2009 Jan 0; 77(1):405-13. Epub 2008 Nov 03.

8/2008
Ma J, Dobry CJ, Krysan DJ, Kumar A. "Unconventional genomic architecture in the budding yeast saccharomyces cerevisiae masks the nested antisense gene NAG1." Eukaryotic cell.. 2008 Aug 0; 7(8):1289-98. Epub 2008 Feb 29.

8/2008
Krysan DJ, Didone L. "A high-throughput screening assay for small molecules that disrupt yeast cell integrity." Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. 2008 Aug 0; 13(7):657-64. Epub 2008 Jul 14.

6/30/2008
Vadaie N, Dionne H, Akajagbor DS, Nickerson SR, Krysan DJ, Cullen PJ. "Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast." The Journal of cell biology.. 2008 Jun 30; 181(7):1073-81.

8/2005
Krysan DJ, Ting EL, Abeijon C, Kroos L, Fuller RS. "Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae." Eukaryotic cell.. 2005 Aug 0; 4(8):1364-74.

9/2004
Krysan DJ. "Effectiveness over time of varicella vaccine." The Journal of pediatrics.. 2004 Sep 0; 145(3):416-7.

8/20/2004
Rozan L, Krysan DJ, Rockwell NC, Fuller RS. "Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and furin." The Journal of biological chemistry.. 2004 Aug 20; 279(34):35656-63. Epub 2004 May 24.

3/2004
Krysan D. "Effectiveness of inactivated influenza vaccine in preventing acute otitis media in young children: a randomized controlled trial." The Journal of pediatrics.. 2004 Mar 0; 144(3):406-7.

12/2002
Rockwell NC, Krysan DJ, Komiyama T, Fuller RS. "Precursor processing by kex2/furin proteases." Chemical reviews.. 2002 Dec 0; 102(12):4525-48.

8/2002
Krysan DJ, Kemper AR. "Claims of equivalence in randomized controlled trials of the treatment of bacterial meningitis in children." The Pediatric infectious disease journal.. 2002 Aug 0; 21(8):753-8.

1/2002
Kemper AR, Krysan DJ. "Reevaluating the efficacy of naturopathic ear drops." Archives of pediatrics & adolescent medicine.. 2002 Jan 0; 156(1):88-9.

2/2001
Krysan DJ, Flynn JT. "Renal transplantation after Streptococcus pneumoniae-associated hemolytic uremic syndrome." American journal of kidney diseases : the official journal of the National Kidney Foundation.. 2001 Feb 0; 37(2):E15.

5/1/2000
Rockwell NC, Krysan DJ, Fuller RS. "Synthesis of peptidyl methylcoumarin esters as substrates and active-site titrants for the prohormone processing proteases Kex2 and PC2." Analytical biochemistry.. 2000 May 1; 280(2):201-8.

8/13/1999
Krysan DJ, Rockwell NC, Fuller RS. "Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides." The Journal of biological chemistry.. 1999 Aug 13; 274(33):23229-34.

1996
Krysan, DJ. "A dramatic reversal of facial selectivity in the Sharpless asymmetric dihydroxylation of a sterically hindered 3-methylidene-benzofuran." Tetrahedron. 1996; 37: 1375.

1996
Krysan, DJ. "A practical synthesis of alpha-acylamino-beta-keto esters: acylation of alkyl hydrogen (acylamino)malonates via the MgCl2/R3N base system." Tetrahedron. 1996; 37: 3303.

1996
Ayers, TA; Schnettler, RA; Marciniak, G; Stewart, KT; Mishra, RK; Krysan, DJ; Bernas, BR; Bhardwaj, P; Fevig, TL. "Enzymatic resolution for an improved enantioselective synthesis of benzofuranyl derivatives: precursors to a class of vitamin E-related antioxidants." Tetrahedron: Asymmetry. 1996; 6: 827.

1995
Krysan DJ. "p-Allyl complexes in organic synthesis: p-allylnickel halides and other (Mo, W, Co, Fe) p-allyl complexes (excluding Pd) in synthesis." Comprehensive Organometallic Chemistry II. 1995; .

1994
Krysan, DJ. "An expedient route to enantiomerically pure allylic alcohols via 1,3-dioxolanone derivatives of 2-hydroxy-carboxylic acids." Synth Commun. 1994; 24: 1589.

1994
Krysan, DJ; Rockway, TR; Haight, AR. "Diastereoselectivity in the osmium-catalyzed dihydroxylation of allylic amides and carbamates." Tetrahedron: Asymmetry. 1994; 4: 625.

1994
Krysan, DJ; Haight, AR; Menzia, JA; Welch, N. "A stereoselective synthesis of the dihydroxyethylene dipeptide isostere A-82768." Tetrahedron. 1994; 21: 6163.

1993
Krysan, DJ; Haight, AR; Lallaman, JE; Landridge, DC; Menzia, JA; Narayanan, BA; Pariza, JR; Reno, DS; Rockway, TW; Stuk, TL; Tien, J. "An improved preparation of (S)-N-(boc)-cyclohexylalaninal: on the Moffat/Swern oxidation of alpha-amino alcohols." Org Prep Proc Inter. 1993; 25: 437.

1993
Edwards, JP; Krysan, DJ; Liebeskind, LS. "A general, regioselective synthesis of substituted benzocyclobutenedione monoacetals." J Organ Chem. 1993; 58: 3942.

1993
Edwards, JP; Krysan, DJ; Liebeskind, LS. "Benannulation of stannylquinones. A new regiocontrolled construction of substituted naptho- and anthraquinones." J Am Chem Soc. 1993; 115: 9868.

1992
Krysan, DJ; Gurski, A; Liebeskind, LS. "A synthesis of highly substituted aromatics through the regiocontrolled construction of cyclobutenones bearing unsaturated substituents at the 4- position." J Am Chem Soc. 1992; 114: 1412.

1992
Friebe, TL; Johnson, JJ; Krysan, DJ; Mackenzie, PB; Sabat, M. "High velocity palladium catalysis." Homogeneous Transition Metal Catalyzed Reactions, Advances in Chemistry Series 230. 1992; : 529-40.

1990
Krysan, DJ; Mackenzie, PB. "A new, convenient synthesis of bis(1,5-cyclooctadiene)nickel(0)." J Organ Chem. 1990; 55: 4109.

8/1/1988
Krysan DJ, Mackenzie PB. "Optically active 2-ethenyl-1,3-dioxolanones as 3-carbon synthons. Allylnickel derivatives as homoenolate equivalents." Journal of the American Chemical Society.. 1988 Aug 1; 110(18):6273-4.

Books & Chapters

2015
Chapter Title: Pneumocystis and Other Less Common
Book Title: Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant
Author List: Gigliotti F, Wright TW, Krysan, DF
Published By: Elsevier Saunders2015 in Phildelphia

2014
Chapter Title: Fusariosis and Scedosporiosis
Book Title: Feigin and Cherry's Textbook of Pediatric Infectious Diseases
Author List: Krysan DJ, Wellington M, Steinbach WJ
Edited By: Cherry J, Harrison GJ, Kaplan S, Peter J, Hotez PJ, Steinbach WJ
Published By: Saunders Elsevier2014 in Philadelphia