Damian J. Krysan, M.D., Ph.D.

Damian J. Krysan, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Office: (585) 275-9729
Fax: (585) 273-1104
Lab: (585) 275-6814

Journal Articles

Showing all 60 journal articles available.

2016 Sep 19
Koselny K, Green J, DiDone L, Halterman JP, Fothergill AW, Wiederhold NP, Patterson TF, Cushion MT, Rappelye C, Wellington M, Krysan DJ. "The celecoxib derivative AR-12 has broad spectrum antifungal activity in vitro and improves the activity of fluconazole in a murine model of cryptococcosis." Antimicrobial agents and chemotherapy. 2016 Sep 19; Epub 2016 Sep 19.
2016 Aug
Krysan DJ. "Challenges in the development of novel anticryptococcal agents." Future medicinal chemistry. 2016 Aug; 8(12):1375-7. Epub 2016 Aug 03.
2016 Jul
Saputo S, Norman KL, Murante T, Horton BN, De La Cruz Diaz J, DiDone L, Colquhoun J, Schroeder JW, Simmons LA, Kumar A, Krysan DJ. "Complex Haploinsufficiency-Based Genetic Analysis of the NDR/Lats Kinase Cbk1 Provides Insight into Its Multiple Functions in Candida albicans." Genetics. 2016 Jul; 203(3):1217-33. Epub 2016 May 20.
2016 Apr 8
Koselny K, Green J, Favazzo L, Glazier VE, DiDone L, Ransford S, Krysan DJ. "Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase." ACS infectious diseases. 2016 Apr 8; 2(4):268-280. Epub 2016 Feb 23.
2016 Jan 8
Hartland K, Pu J, Palmer M, Dandapani S, Moquist PN, Munoz B, DiDone L, Schreiber SL, Krysan DJ. "High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling." ACS infectious diseases. 2016 Jan 8; 2(1):93-102. Epub 2015 Nov 06.
2015 May
Krysan DJ. "Toward improved anti-cryptococcal drugs: Novel molecules and repurposed drugs." Fungal genetics and biology : FG & B. 2015 May; 78:93-8. Epub 2014 Dec 13.
Butts A, Martin JA, DiDone L, Bradley EK, Mutz M, Krysan DJ. "Structure-activity relationships for the antifungal activity of selective estrogen receptor antagonists related to tamoxifen." PloS one. 2015 10(5):e0125927. Epub 2015 May 27.
Forbes L, Ebsworth-Mojica K, DiDone L, Li SG, Freundlich JS, Connell N, Dunman PM, Krysan DJ. "A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis." PloS one. 2015 10(6):e0129234. Epub 2015 Jun 22.
2014 Nov 20
Brown JC, Nelson J, VanderSluis B, Deshpande R, Butts A, Kagan S, Polacheck I, Krysan DJ, Myers CL, Madhani HD. "Unraveling the biology of a fungal meningitis pathogen using chemical genetics." Cell. 2014 Nov 20; 159(5):1168-87.
2014 Oct 23
Perlmutter JI, Forbes LT, Krysan DJ, Ebsworth-Mojica K, Colquhoun JM, Wang JL, Dunman PM, Flaherty DP. "Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus." Journal of medicinal chemistry. 2014 Oct 23; 57(20):8540-62. Epub 2014 Oct 06.
2014 Sep
Saputo S, Kumar A, Krysan DJ. "Efg1 directly regulates ACE2 expression to mediate cross talk between the cAMP/PKA and RAM pathways during Candida albicans morphogenesis." Eukaryotic cell. 2014 Sep; 13(9):1169-80. Epub 2014 Jul 07.
2014 Sep
Hoy Z, Dodds Ashley ES, Weinberg GA, Krysan DJ. "Voriconazole Therapeutic Drug Monitoring." Journal of the Pediatric Infectious Diseases Society. 2014 Sep; 3(3):270-1. Epub 2014 Mar 30.
2014 Jun
Krysan DJ, Sutterwala FS, Wellington M. "Catching fire: Candida albicans, macrophages, and pyroptosis." PLoS pathogens. 2014 Jun; 10(6):e1004139. Epub 2014 Jun 26.
2014 May 1
Roemer T, Krysan DJ. "Antifungal drug development: challenges, unmet clinical needs, and new approaches." Cold Spring Harbor perspectives in medicine. 2014 May 1; 4(5)Epub 2014 May 01.
2014 May
Falsetta ML, Klein MI, Colonne PM, Scott-Anne K, Gregoire S, Pai CH, Gonzalez M, Watson G, Krysan DJ, Bowen WH, Koo H. "Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo." Infection and immunity. 2014 May; 82(5):1968-81. Epub 2014 Feb 24.
2014 Feb 11
Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, Didone L, Tabroff J, Childers WE, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ. "Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo." mBio. 2014 Feb 11; 5(1):e00765-13. Epub 2014 Feb 11.
2014 Feb
Wellington M, Koselny K, Sutterwala FS, Krysan DJ. "Candida albicans triggers NLRP3-mediated pyroptosis in macrophages." Eukaryotic cell. 2014 Feb; 13(2):329-40. Epub 2013 Dec 27.
2013 Feb
Butts A, Didone L, Koselny K, Baxter BK, Chabrier-Rosello Y, Wellington M, Krysan DJ. "A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis." Eukaryotic cell. 2013 Feb; 12(2):278-87. Epub 2012 Dec 14.
2013 Jan
Chabrier-Roselló Y, Gerik KJ, Koselny K, Didone L, Lodge JK, Krysan DJ. "Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes." Eukaryotic cell. 2013 Jan; 12(1):12-22. Epub 2012 Oct 19.
2012 Sep
Butts A, Krysan DJ. "Antifungal drug discovery: something old and something new." PLoS pathogens. 2012 Sep; 8(9):e1002870. Epub 2012 Sep 06.
2012 Jun
Saputo S, Chabrier-Rosello Y, Luca FC, Kumar A, Krysan DJ. "The RAM network in pathogenic fungi." Eukaryotic cell. 2012 Jun; 11(6):708-17. Epub 2012 Apr 27.
Wellington M, Koselny K, Krysan DJ. "Candida albicans morphogenesis is not required for macrophage interleukin 1? production." mBio. 2012 4(1):e00433-12. Epub 2012 Dec 26.
2011 Aug
Didone L, Oga D, Krysan DJ. "A novel assay of biofilm antifungal activity reveals that amphotericin B and caspofungin lyse Candida albicans cells in biofilms." Yeast (Chichester, England). 2011 Aug; 28(8):561-8. Epub 2011 Jun 15.
2011 May 20
Baxter BK, Didone L, Oga D, Schor S, Krysan DJ. "Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules." ACS chemical biology. 2011 May 20; 6(5):502-10. Epub 2011 Feb 22.
2011 Apr
Bharucha N, Chabrier-Roselló Y, Xu T, Johnson C, Sobczynski S, Song Q, Dobry CJ, Eckwahl MJ, Anderson CP, Benjamin AJ, Kumar A, Krysan DJ. "A Large-Scale Complex Haploinsufficiency-Based Genetic Interaction Screen in Candida albicans: Analysis of the RAM Network during Morphogenesis." PLoS genetics. 2011 Apr; 7(4):e1002058. Epub 2011 Apr 28.
2011 Apr
Bharucha N, Chabrier-Rosello Y, Xu T, Johnson C, Sobczynski S, Song Q, Dobry CJ, Eckwah MJ, Anderson CP, Benjamin AJ, Kumar A, Krysan DJ. "A large-scale complex haploinsufficiency-based genetic interaction screen in Candida albicans: analysis of the RAM network during morphogenesis." PLoS genetics. 2011 Apr; 7(4):e1002058.
2011 Mar
Kainth MK, Krysan DJ. "Age and symptoms affect the prevalence of group A beta-hemolytic streptococcus in pharyngeal cultures of school-age children." The Journal of pediatrics. 2011 Mar; 158(3):515-6.
2010 Nov
Miller KA, Didone L, Krysan DJ. "Extracellular secretion of overexpressed glycosylphosphatidylinositol-linked cell wall protein Utr2/Crh2p as a novel protein quality control mechanism in Saccharomyces cerevisiae." Eukaryotic cell. 2010 Nov; 9(11):1669-79. Epub 2010 Sep 10.
2010 Jun
Didone L, Scrimale T, Baxter BK, Krysan DJ. "A high-throughput assay of yeast cell lysis for drug discovery and genetic analysis." Nature protocols. 2010 Jun; 5(6):1107-14. Epub 2010 May 27.
2009 Aug
Dolan K, Montgomery S, Bucchiet B, Didone L, Wellington M, Krysan DJ. "Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization." Antimicrobial agents and chemotherapy. 2009 Aug; 53(8):3337-46. Epub 2009 Jun 01.
2009 May
Krysan DJ. "The cell wall and endoplasmic reticulum stress responses are coordinately regulated in Saccharomyces cerevisiae." Communicative & integrative biology. 2009 May; 2(3):233-5.
2009 Jan
Scrimale T, Didone L, de Mesy Bentley KL, Krysan DJ. "The unfolded protein response is induced by the cell wall integrity mitogen-activated protein kinase signaling cascade and is required for cell wall integrity in Saccharomyces cerevisiae." Molecular biology of the cell. 2009 Jan; 20(1):164-75. Epub 2008 Oct 29.
2009 Jan
Wellington M, Dolan K, Krysan DJ. "Live Candida albicans suppresses production of reactive oxygen species in phagocytes." Infection and immunity. 2009 Jan; 77(1):405-13. Epub 2008 Nov 03.
2008 Aug
Ma J, Dobry CJ, Krysan DJ, Kumar A. "Unconventional genomic architecture in the budding yeast saccharomyces cerevisiae masks the nested antisense gene NAG1." Eukaryotic cell. 2008 Aug; 7(8):1289-98. Epub 2008 Feb 29.
2008 Aug
Krysan DJ, Didone L. "A high-throughput screening assay for small molecules that disrupt yeast cell integrity." Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. 2008 Aug; 13(7):657-64. Epub 2008 Jul 14.
2008 Jun 30
Vadaie N, Dionne H, Akajagbor DS, Nickerson SR, Krysan DJ, Cullen PJ. "Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast." The Journal of cell biology. 2008 Jun 30; 181(7):1073-81.
2005 Aug
Krysan DJ, Ting EL, Abeijon C, Kroos L, Fuller RS. "Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae." Eukaryotic cell. 2005 Aug; 4(8):1364-74.
2004 Sep
Krysan DJ. "Effectiveness over time of varicella vaccine." The Journal of pediatrics. 2004 Sep; 145(3):416-7.
2004 Aug 20
Rozan L, Krysan DJ, Rockwell NC, Fuller RS. "Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and furin." The Journal of biological chemistry. 2004 Aug 20; 279(34):35656-63. Epub 2004 May 24.
2004 Mar
Krysan D. "Effectiveness of inactivated influenza vaccine in preventing acute otitis media in young children: a randomized controlled trial." The Journal of pediatrics. 2004 Mar; 144(3):406-7.
2002 Aug
Krysan DJ, Kemper AR. "Claims of equivalence in randomized controlled trials of the treatment of bacterial meningitis in children." The Pediatric infectious disease journal. 2002 Aug; 21(8):753-8.
2002 Jan
Kemper AR, Krysan DJ. "Reevaluating the efficacy of naturopathic ear drops." Archives of pediatrics & adolescent medicine. 2002 Jan; 156(1):88-9.
Rockwell NC, Krysan DJ, Komiyama T, Fuller RS. "Precursor processing by kex2/furin proteases." Chemical reviews. 2002 102(12):4525-48.
2001 Feb
Krysan DJ, Flynn JT. "Renal transplantation after Streptococcus pneumoniae-associated hemolytic uremic syndrome." American journal of kidney diseases : the official journal of the National Kidney Foundation. 2001 Feb; 37(2):E15.
2000 May 1
Rockwell NC, Krysan DJ, Fuller RS. "Synthesis of peptidyl methylcoumarin esters as substrates and active-site titrants for the prohormone processing proteases Kex2 and PC2." Analytical biochemistry. 2000 May 1; 280(2):201-8.
1999 Aug 13
Krysan DJ, Rockwell NC, Fuller RS. "Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides." The Journal of biological chemistry. 1999 Aug 13; 274(33):23229-34.
Krysan, DJ. "A dramatic reversal of facial selectivity in the Sharpless asymmetric dihydroxylation of a sterically hindered 3-methylidene-benzofuran." Tetrahedron. 1996; 37: 1375. Link
Krysan, DJ. "A practical synthesis of alpha-acylamino-beta-keto esters: acylation of alkyl hydrogen (acylamino)malonates via the MgCl2/R3N base system." Tetrahedron. 1996; 37: 3303. Link
Ayers, TA; Schnettler, RA; Marciniak, G; Stewart, KT; Mishra, RK; Krysan, DJ; Bernas, BR; Bhardwaj, P; Fevig, TL. "Enzymatic resolution for an improved enantioselective synthesis of benzofuranyl derivatives: precursors to a class of vitamin E-related antioxidants." Tetrahedron: Asymmetry. 1996; 6: 827. Link
Krysan DJ. "p-Allyl complexes in organic synthesis: p-allylnickel halides and other (Mo, W, Co, Fe) p-allyl complexes (excluding Pd) in synthesis." Comprehensive Organometallic Chemistry II. 1995; . Link
Krysan, DJ. "An expedient route to enantiomerically pure allylic alcohols via 1,3-dioxolanone derivatives of 2-hydroxy-carboxylic acids." Synth Commun. 1994; 24: 1589. Link
Krysan, DJ; Rockway, TR; Haight, AR. "Diastereoselectivity in the osmium-catalyzed dihydroxylation of allylic amides and carbamates." Tetrahedron: Asymmetry. 1994; 4: 625. Link
Krysan, DJ; Haight, AR; Menzia, JA; Welch, N. "A stereoselective synthesis of the dihydroxyethylene dipeptide isostere A-82768." Tetrahedron. 1994; 21: 6163. Link
Krysan, DJ; Haight, AR; Lallaman, JE; Landridge, DC; Menzia, JA; Narayanan, BA; Pariza, JR; Reno, DS; Rockway, TW; Stuk, TL; Tien, J. "An improved preparation of (S)-N-(boc)-cyclohexylalaninal: on the Moffat/Swern oxidation of alpha-amino alcohols." Org Prep Proc Inter. 1993; 25: 437. Link
Edwards, JP; Krysan, DJ; Liebeskind, LS. "A general, regioselective synthesis of substituted benzocyclobutenedione monoacetals." J Organ Chem. 1993; 58: 3942.
Edwards, JP; Krysan, DJ; Liebeskind, LS. "Benannulation of stannylquinones. A new regiocontrolled construction of substituted naptho- and anthraquinones." J Am Chem Soc. 1993; 115: 9868.
Krysan, DJ; Gurski, A; Liebeskind, LS. "A synthesis of highly substituted aromatics through the regiocontrolled construction of cyclobutenones bearing unsaturated substituents at the 4- position." J Am Chem Soc. 1992; 114: 1412.
Friebe, TL; Johnson, JJ; Krysan, DJ; Mackenzie, PB; Sabat, M. "High velocity palladium catalysis." Homogeneous Transition Metal Catalyzed Reactions, Advances in Chemistry Series 230. 1992; : 529-40.
Krysan, DJ; Mackenzie, PB. "A new, convenient synthesis of bis(1,5-cyclooctadiene)nickel(0)." J Organ Chem. 1990; 55: 4109.
1988 Aug 1
Krysan DJ, Mackenzie PB. "Optically active 2-ethenyl-1,3-dioxolanones as 3-carbon synthons. Allylnickel derivatives as homoenolate equivalents." Journal of the American Chemical Society. 1988 Aug 1; 110(18):6273-4.