Damian J. Krysan, M.D., Ph.D.

Damian J. Krysan, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Office: (585) 275-9729
Fax: (585) 273-1104
Lab: (585) 275-6814

Professional Bio

Associate Chair of Basic Research

Research Bio

Dr. Krysan's research focuses on two broad areas: 1) antifungal and antibiotic drug discovery and 2) fungal pathogenesis.



First, our antifungal and antibiotic drug discovery work involves high-throughput screening, characterizing in vitro and in vivo activity, determining mechanism of action and structure-activity optimization of new leads. We are currently studying triphenylethylene-bases molecules similar to tamoxifen as anti-cryptococcal agents, PDK1 kinase inhibitors as antifungal agents (in collaboration with Dr. Robert Boeckman from the Department of Chemistry), and a variety of new molecular scaffolds. High-throughput screening projects involve (in collaboration with Dr. Paul Dunman from the Department of Microbiology) the ESKAPE (Enterococcus, Staphylococcus, Klebsiella, Acinetobacter, Pseudomonas and Enterobacter) bacterial pathogens and Mycobacterium tuberculosis.

Second, we use large-scale genetic approaches to study the pathogenesis and host-pathogen interactions of Candida albicans, the most common human fungal pathogen. These studies are carried out in collaboration with Dr. Anuj Kumar (University of Michigan), and Dr. Melanie Wellington (University of Rochester, Pediatric Infectious Diseases). We are particularly interested in how genetic networks regulate morphogenesis and interactions with macrophages.

Awards & Honors (Local)

Featured APS New Member of the Month 2013
Elected to American Pediatric Society 2013
1st Tennessee Chair Distinguished Visiting Professor 2012
Ruth A. Lawrence Academic Faculty Service Award in Research 2012

Recent Journal Articles

Showing the 5 most recent journal articles. 59 available »

2016 Aug
Krysan DJ. "Challenges in the development of novel anticryptococcal agents." Future medicinal chemistry. 2016 Aug; 8(12):1375-7. Epub 2016 Aug 03.
2016 Jul
Saputo S, Norman KL, Murante T, Horton BN, De La Cruz Diaz J, DiDone L, Colquhoun J, Schroeder JW, Simmons LA, Kumar A, Krysan DJ. "Complex Haploinsufficiency-Based Genetic Analysis of the NDR/Lats Kinase Cbk1 Provides Insight into Its Multiple Functions in Candida albicans." Genetics. 2016 Jul; 203(3):1217-33. Epub 2016 May 20.
2016 Apr 8
Koselny K, Green J, Favazzo L, Glazier VE, DiDone L, Ransford S, Krysan DJ. "Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase." ACS infectious diseases. 2016 Apr 8; 2(4):268-280. Epub 2016 Feb 23.
2016 Jan 8
Hartland K, Pu J, Palmer M, Dandapani S, Moquist PN, Munoz B, DiDone L, Schreiber SL, Krysan DJ. "High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling." ACS infectious diseases. 2016 Jan 8; 2(1):93-102. Epub 2015 Nov 06.
2015 May
Krysan DJ. "Toward improved anti-cryptococcal drugs: Novel molecules and repurposed drugs." Fungal genetics and biology : FG & B. 2015 May; 78:93-8. Epub 2014 Dec 13.

Current Appointments

Associate Professor - Department of Pediatrics, Infectious Diseases (SMD) - Primary
Associate Professor - Department of Microbiology and Immunology (SMD)

Specialties

Pediatric Infectious Diseases - American Board of Pediatrics
Pediatrics - American Board of Pediatrics

Education

MD | Medicine | University of Michigan Medical School2000
PhD | Organic Chemistry | Northwestern University1989
BA | Chemistry | Grinnell College1984

Post-Doctoral Training & Residency

Fellowship in Pediatric Infectious Disease at University of Michigan Medical Center07/01/2002 - 06/30/2005
Residency in Pediatrics at University of Michigan Medical Center07/01/2001 - 06/30/2002
Internship in Pediatrics at University of Michigan Medical Center06/24/2000 - 06/30/2001