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Damian J. Krysan, M.D., Ph.D.

Pediatrics

Clinical Interests

Infectious Diseases

Contact Information

Phone Numbers

Appointment: (585) 275-5944

Fax: (585) 273-1104

Office: (585) 275-9729

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Biography

Pediatric infectious diseases

Professional Background

Associate Chair of Basic Research

Research

Dr. Krysan's research focuses on two broad areas: 1) antifungal and antibiotic drug discovery and 2) fungal pathogenesis. First, our antifungal and antibiotic drug discovery work involves high-throughput screening, characterizing in vitro and in vivo activity, determining mechanism of action and structure-activity optimization of new leads. We are currently studying triphenylethylene-bases molecules similar to tamoxifen as anti-cryptococcal agents, PDK1 kinase inhibitors as antifungal agents (in collaboration with Dr. Robert Boeckman from the Department of Chemistry), and a variety of new molecular scaffolds. High-throughput screening projects involve (in collaboration with Dr. Paul Dunman from the Department of Microbiology) the ESKAPE (Enterococcus, Staphylococcus, Klebsiella, Acinetobacter, Pseudomonas and Enterobacter) bacterial pathogens and Mycobacterium tuberculosis. Second, we use large-scale genetic approaches to study the pathogenesis and host-pathogen interactions of Candida albicans, the most common human fungal pathogen. These studies are carried out in collaboration with Dr. Anuj Kumar (University of Michigan), and Dr. Melanie Wellington (University of Rochester, Pediatric Infectious Diseases). We are particularly interested in how genetic networks regulate morphogenesis and interactions with macrophages.

Credentials

Faculty Appointments

Specialties

  • Pediatrics
  • Pediatric Infectious Diseases - American Board of Pediatrics

Education

1984
BA | Grinnell College
Chemistry

1989
PhD | Northwestern University
Organic Chemistry

2000
MD | University of Michigan Medical School
Medicine

Post-doctoral Training & Residency

06/24/2000 - 06/30/2001
Internship in Pediatrics at University of Michigan Medical Center

07/01/2001 - 06/30/2002
Residency in Pediatrics at University of Michigan Medical Center

07/01/2002 - 06/30/2005
Fellowship in Pediatrics: Pediatric Infectious Diseases at University of Michigan Medical Center

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Awards

2013
Featured APS New Member of the Month

2013
Elected to American Pediatric Society

2012
1st Tennessee Chair Distinguished Visiting Professor

2012
Ruth A. Lawrence Academic Faculty Service Award in Research

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Publications

Journal Articles

2/17/2017
Krysan DJ. "The unmet clinical need of novel antifungal drugs." Virulence.. 2017 Feb 17; 8(2):135-137.

12/2016
Koselny K, Green J, DiDone L, Halterman JP, Fothergill AW, Wiederhold NP, Patterson TF, Cushion MT, Rappelye C, Wellington M, Krysan DJ. "The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis." Antimicrobial agents and chemotherapy.. 2016 Dec 0; 60(12):7115-7127. Epub 2016 Nov 21.

8/2016
Krysan DJ. "Challenges in the development of novel anticryptococcal agents." Future medicinal chemistry.. 2016 Aug 0; 8(12):1375-7. Epub 2016 Aug 03.

Books & Chapters

2015
Chapter Title: Pneumocystis and Other Less Common
Book Title: Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant
Author List: Gigliotti F, Wright TW, Krysan, DF
Published By: Elsevier Saunders2015 in Phildelphia

2014
Chapter Title: Fusariosis and Scedosporiosis
Book Title: Feigin and Cherry's Textbook of Pediatric Infectious Diseases
Author List: Krysan DJ, Wellington M, Steinbach WJ
Edited By: Cherry J, Harrison GJ, Kaplan S, Peter J, Hotez PJ, Steinbach WJ
Published By: Saunders Elsevier2014 in Philadelphia

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