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James M. Roger, D.D.S.

Contact Information

Phone Numbers

Fax: (585) 276-0190

Biography

Research

B cells have been implicated as central players in the autoimmune diseases Sjögren's Syndrome (SS), Systemic Lupus Erythematosus (SLE), and Rheumatoid Arthritis (RA). While it has been reported that B cells participate in both immune and autoimmune response through their traditional role of antibody (and auto-antibody) production--B cells are also known to participate, possibly pathologically, through antibody independent functions such as cytokine production and antigen presentation. It has long been reported that B cells are capable of cytokine production; B cells activated through the B cell Receptor (BCR) or Toll-Like Receptors (TLR) produce cytokines such as IL-10, IL-6 and TNFa. Preliminary data has shown that B cells produce a large and diverse array of cytokines in biologically significant quantities. Further data has shown that B cells can be induced to make pro-inflammatory cytokines (IFNg, IL-12p40, and TNFa) when stimulated by Th1 cells, or cytokines associated with allergic responses (IL-4) when stimulated by Th2 cells. This B / T cell communication indicates potentially complex effector roles when considering cytokine-producing B cells. In mice, IL-10 producing B cells seem to ameliorate symptoms of autoimmune diseases of RA and Inflammatory Bowel Disease. While the observation that B cells are capable of producing a variety of effector cytokines under differing stimulation conditions is tantalizing, a systematic approach to dissect the function of these cytokine producing B cells is necessary to elucidate their effector functions in both health and autoimmune disease. The immuno-modulatory effects of the cytokines produced and the hypothesis that cytokine-producing B cells contribute in both the healthy state as well as the autoimmune conditions of Sjögren's Syndrome, Lupus and Rheumatoid, through systemic inflammatory modulation and target-tissue influences are being evaluated.

Credentials

Faculty Appointments

Education

1998
Sc.B. | Brown University
Chemistry

2008
D.D.S. | Marquette University
Dentistry

2011
M.S. | University of Rochester, School of Medicine and Dentistry
Immunology

Post-doctoral Training & Residency

07/01/2012 - 06/30/2013
Internship in Dentist-Oral and Maxillofacial Surgery at University of Rochester Medical Center

07/01/2013 - 06/30/2017
Residency in Dentist-Oral and Maxillofacial Surgery at University of Rochester Medical Center

Awards

2008
2008 Volpe Prize for Periodontal Research, Finalist
Sponsor: The Ohio State University, Columbus, OH

2007 - 2008
Sjögren's Syndrome Foundation Fellowship; "Autoantibody characterization in salivary gland B cells in primary Sjögren'

2007
Dentsply/SCADA Student Clinician Research Program, Marquette representative at the ADA Annual Meeting

2006 - 2007
Academic Dental Careers Fellowship Program Fellow
Sponsor: ADEA

2006
Best Manuscript, Journal of Dental Education
Location: American Association for Dental Education

2006
1st Prize Dental Research Division, Poster Presentation
Sponsor: Marquette University Research Day

2005
Recipient of the Robert Burkhardt Memorial Scholarship
Sponsor: Pennsylvania Academy of Stomatology

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Publications

Journal Articles

4/2008
Rogér JM. "The Academic Dental Careers Fellowship Program: a pilot program to introduce dental students to academia." Journal of dental education.. 2008 Apr 0; 72(4):438-47.

4/2008
Rogér JM, Wehmeyer MM, Milliner MS. "Reflections on academic careers by current dental school faculty." Journal of dental education.. 2008 Apr 0; 72(4):448-57.

5/2007
Rogér JM, Javarone JA, Ealba EL, Markiewicz MR, Morlandt AB. "The National Student Research Group of the AADR--an introduction." Journal of dental research.. 2007 May 0; 86(5):388-91.

Books & Chapters

2006
Book Title: Dental Calcification Stages of the Permanent M1 and M2 in US Children of African
Author List: Monge, J., Mann, A., Stout, A., Roger, J., Wadenya, R.
Published By: Springer Verlag2006

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