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Nina F. Schor, M.D., Ph.D.

Pediatrics

Contact Information

Phone Numbers

Office: (585) 275-4673

Fax: (585) 273-1079

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentNot Accepting New Patients

Research Labs

Biography

Dr. Nina F. Schor is the seventh Chair of the Department of Pediatrics and the William H. Eilinger Professor of Pediatrics at the University of Rochester Medical Center. She is also Pediatrician-in-Chief of the Golisano Children's Hospital at Strong and Professor in the Departments of Neurology and Neuroscience. Before arriving in Rochester, she was the Chief of the Division of Child Neurology in the Department of Pediatrics at Children's Hospital of Pittsburgh. She was Professor of Pediatrics, Neurology, and Pharmacology at the University of Pittsburgh and held the Carol Ann Craumer Endowed Chair in Pediatric Research at Children's Hospital of Pittsburgh. She served as President of the Child Neurology Society from 2013-2015 and is currently a Director of the American Board of Psychiatry and Neurology. Her research designed to understand and find effective treatments for neuroblastoma has been funded by the NIH and a host of research foundations since 1988.

Research

The laboratory of Dr. Nina F. Schor began with a focus on designing and testing in preclinical models targeted therapy for neuroblastoma, the most common solid tumor of childhood and a derivative of the neural crest. Therapeutic approaches that have been pioneered in Dr. Schor's laboratory include:

(1) adjunctive use of 6-hydroxydopamine (tumor cell ablative agent) with TEMPOL (selective normal cell chemoprotectant);

(2) adjunctive use of neocarzinostatin (non-selective chemotherapeutic prodrug) with 6-mercaptodopamine (neural crest-selective activator of neocarzinostatin);

(3) caspase 3-dependent potentiation of apoptosis induced by enediyne chemotherapeutic agents in Bcl-2-overexpressing tumors; and

(4) potentiation of apoptosis induced by chemotherapeutic agents with agonists and antagonists at specific neurotrophin receptors.

In the process of this work, Dr. Schor's laboratory has evolved several distinct lines of inquiry and drug and mechanism discovery. For example, the peripheral administration of 6-hydroxydopamine alone resulted in an autonomic neuropathy that mimicked that seen in patients with Parkinson's disease. Dr. Schor's group has used this model to examine the development of auto-recycling antioxidants for use in Parkinson's disease. Since moving from the University of Pittsburgh to the University of Rochester, Dr. Schor and her colleagues have been piloting mitochondrially-targeted auto-recycling antioxidants and gene therapy with constructs that code for endogenous neuroprotective species (e.g., the intracellular domain of the p75 neurotrophin receptor), respectively, in this model system.

Another example of work that developed from the targeted chemotherapeutic strategies relates to the discovery by Dr. Schor and her group that, not only is the p75 neurotrophin receptor an excellent substrate for presenilin, liberating its intracellular domain; this intracellular domain is protective against oxidative stress and facilitatory of antimitotic activity by a mechanism that involves translocation of NF-kappaB to the nucleus and up-regulation of all of the enzymes responsible for cholesterol biosynthesis. This is of particular interest in Alzheimer's disease because, while p75 is ubiquitously expressed in the embryonic brain, it is selectively highly expressed in the nucleus basalis of Meynert in the adult brain. Furthermore, genetically engineered cells that express only the familial Alzheimer's disease mutant presenilin do not exhibit p75-mediated protection from oxidative stress.

Credentials

Faculty Appointments

Specialties

  • Neurology with Special Qualifications in Child Neurology - American Board of Psychiatry and Neurology
  • Pediatrics - American Board of Pediatrics

Education

1981
MD | Cornell University Medical School
Medicine

1980
PhD | Rockefeller University
Medical Biochemistry

1975
BS | Yale University
Molecular Biophysics Biochemistry

Post-doctoral Training & Residency

07/01/1981 - 06/30/1982
Internship in Pediatrics at Children's Hospital Boston

07/01/1982 - 06/30/1983
Residency in Pediatrics at Children s Hospital

07/01/1983 - 06/30/1986
Fellowship in Neurology: Child Neurology at Children s Hospital

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Awards

2017
National Research Mentoring Network Master Mentor
Sponsor: National Research Mentoring Network

2012
Fellow
Sponsor: American Association for the Advancement of Science

2012
Keynote Speaker/Panel Member, Tri-Institutional MD-PhD Program 40th Anniversary Student Retreat
Sponsor: Weill Cornell/Rockefeller/Sloan-Kettering
Location: New York City, NY

2010
Annual Pediatric Neurology Invited Lecturer
Sponsor: Cleveland Clinic
Location: Cleveland OH

2010
Keynote Speaker, University of Utah Neurology Retreat
Sponsor: University of Utah
Location: Salt Lake City, UT

2009
Baldwin Lecturer
Sponsor: University of Maryland Medical Center
Location: Baltimore, MD

2008
E. Stanley Emery Professor
Sponsor: University of Vermont Medical Center
Location: Burlington, VT

2008
Dean's Distinguished Lecturer
Sponsor: University of Arkansas Medical Center
Location: Fayetteville, AR

2007
William H. Eilinger Endowed Chair of Pediatrics
Sponsor: University of Rochester Medical Center
Location: Rochester NY

2006
Keynote Speaker
Sponsor: University of Rochester MSTP Program Retreat
Location: Rochester, NY

2005
Distinguished Neurology Teacher Award
Sponsor: American Neurological Association
Location: San Diego, CA

2004 - Present
Best Doctors in America
Sponsor: America's Best Doctors

2004
Distinguished Alumni Speaker
Sponsor: Intel Science Talent Search
Location: Washington, DC

2004
Distinguished Alumni Speaker Series Speaker
Sponsor: Tri-Institutional Distinguished Alumni Speaker
Location: Cornell-Rockefeller-Memorial Sloan Kettering, NY

2002
Named to Best Doctors in America
Sponsor: America's Best Doctors

2000
Craumer Endowed Professorship for Pediatrics Research
Sponsor: Children's Hospital of Pittsburgh
Location: Pittsburgh, PA

1999
Named to Best Doctors in America
Sponsor: America's Best Doctors

1999
Volunteer in the Schools Award
Sponsor: Pittsburgh Elementary Gifted Center
Location: Pittsburgh, PA

1997
Teaching Excellence Award, Second Year Medical School Class
Sponsor: University of Pittsburgh
Location: Pittsburgh, PA

1996
Chancellor's Distinguished Teaching Award
Sponsor: University of Pittsburgh
Location: Pittsburgh, PA

1995
Kenneth E. Schuitt-Dean's Master Educator Award
Sponsor: University of Pittsburgh School of Medicine
Location: Pittsburgh, PA

1991
Presidential Citation
Sponsor: Jewish Community Center of Pittsburgh

1991
Conferral of tenure
Sponsor: University of Pittsburgh School of Medicine
Location: Pittsburgh, PA

1990
Michael E. Miller Young Investigator Award
Sponsor: Children's Hospital of Pittsburgh

1990
Benjamin N. Cardozo High School Women in Science Award

1987 - 1989
Child Neurology Fellows' Award for Excellence in Teaching

1985
Ruth Estrin Goldberg Memorial Award for Cancer Research
Sponsor: Ruth Estrin Goldberg Memorial Foundation

1980
Alfred A. Richman Award for Cardiopulmonary Research
Sponsor: American College of Chest Physicians

1973
Cold Spring Harbor Laboratory Undergraduate Research Participant

1972
American Academy of Achievement Award

1972
Tomorrow's Scientists and Engineers Award

1972
National Merit Scholar

1972
Yale National Scholar

1972
Westinghouse Science Talent Search, First Prize

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Publications

Journal Articles

6/14/2017
Schor NF. "Chance juxtapositions and (un)biased methods in science: More efficient at inefficiency." Neurology.. 2017 Jun 14; Epub 2017 Jun 14.

6/2017
Li X, Eberhardt A, Hansen JN, Bohmann D, Li H, Schor NF. "Methylation of the phosphatase-transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2017 Jun 0; 31(6):2327-2339. Epub 2017 Feb 17.

4/4/2017
Jeste SS, Schor NF. "Autism today: Have we put the cart before the horse?" Neurology.. 2017 Apr 4; 88(14):1303-1304. Epub 2017 Mar 08.

Books & Chapters

2006
Chapter Title: Neurological Sequelae of Rheumatologic Disease (in press)
Book Title: Pediatric Neurology
Author List: Schor NF, Sheets R, Szer IS, Ashwal S
Edited By: Swaiman K, Ashwal S, Ferriero D
Published By: Mosby2006

2005
Chapter Title: Migraine in Children and Adolescents
Book Title: Current Management in Child Neurology
Author List: Schor NF
Edited By: Maria B
Published By: BC Decker2005 in Hamilton, Ontario, Canada

2002
Book Title: Neurology of Neuroblastoma: Neuroblastoma as a Neurobiological Disease
Author List: Schor NF
Published By: Kluwer Academic Publishers2002 in Boston, MA

VIEW ALL PUBLICATIONS

Videos

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Dr. Michael O'Reilly-Perinatal and Pediatric Origins of Disease Program.mov

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Dr. Schor discusses Golisano Children's Hospital expansion

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Pediatrician-in-Chief Shows off New Golisano Children's Hospital Plans