Yi Zhang, Ph.D., M.S., M.B.A.

Yi Zhang, Ph.D., M.S., M.B.A.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Office: (585) 275-1950
Fax: (585) 756-4468

Lab Information

Visit Lab Website »

Research Bio

Dr. Zhang's graduate work revealed a role for the Wnt regulator Axin in the regulation of Jun N-terminal kinase. As a postdoc, he discovered a connection between the anti-angiogenesis drug fumagillin and the Wnt signaling pathway, which both provided strong evidence for the role of the Wnt pathway in angiogenesis, as well as explained the role of the fumagillin target, MetAP2, in cellular growth control.

Awards & Honors (Local)

New York State Stem Cell Sciences funding | New York State Department of Health 2014 - Present
Empire State Stem Cell Board IDEA Award | New York State 2011
James P. Wilmot Cancer Center Symposium 1st place award | University of Rochester Medical Center 2008
Advanced Training in Science Teaching | Yale Graduate Teaching Center 2006
Life Science Research Foundation Finalist | Princeton University 2003
Helen Hay Whitney Foundation finalist 2003

Recent Journal Articles

Showing the 5 most recent journal articles. 28 available »

2016 Jun 24
Wilson M, Tsakraklides V, Tran M, Xiao YY, Zhang Y, Perkins AS. "EVI1 Interferes with Myeloid Maturation via Transcriptional Repression of Cebpa, via Binding to Two Far Downstream Regulatory Elements." The Journal of biological chemistry. 2016 Jun 24; 291(26):13591-607. Epub 2016 Apr 21.
2014 Mar
Juneja SC, Vonica A, Zeiss C, Lezon-Geyda K, Yatsula B, Sell DR, Monnier VM, Lin S, Ardito T, Eyre D, Reynolds D, Yao Z, Awad HA, Yu H, Wilson M, Honnons S, Boyce BF, Xing L, Zhang Y, Perkins AS. "Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia." Bone. 2014 Mar; 60:148-61. Epub 2013 Dec 04.
Glass C, Wilson M, Gonzalez R, Zhang Y, Perkins AS. "The role of EVI1 in myeloid malignancies." Blood cells, molecules & diseases. 2014 53(1-2):67-76. Epub 2014 Feb 01.
Bard-Chapeau EA, Szumska D, Jacob B, Chua BQ, Chatterjee GC, Zhang Y, Ward JM, Urun F, Kinameri E, Vincent SD, Ahmed S, Bhattacharya S, Osato M, Perkins AS, Moore AW, Jenkins NA, Copeland NG. "Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects." PloS one. 2014 9(2):e89397. Epub 2014 Feb 27.
2013 Oct 17
Zhang Y, Owens K, Hatem L, Glass CH, Karuppaiah K, Camargo F, Perkins AS. "Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia." Blood. 2013 Oct 17; 122(16):2888-92. Epub 2013 Sep 10.

Current Appointments

Research Associate Professor - Department of Pathology and Laboratory Medicine (SMD) - Primary


MBA | Finance, Accounting, Healthcare Business | Simon Business School, University of Rochester2014
Medical Management Master | William E. Simon Graduate School of Business Administration, University of Rochester Business School2012
Research Faculty | Chemical Genetics Chemical Genomics | Yale University2007
Post-doc | Chemical Genetics Chemical Genomics | Yale University2004
PhD | Molecular and Cell Biology | National University of Singapore, IMCB, A-STAR and NUS2001
BS | Biophysics and Physiology | Fudan University1990

Post-Doctoral Training & Residency

Research Faculty, Anti-Cancer Drug Mode-of-Action Study, Chemical Genetics and Chemical Genomics, Department of MCDB and Yale Center for Molecular Discovery, Yale University 2007
Postdoctoral Fellow, Chemical Genetics and Chemical Genomics, (advisor: Craig M Crews, AAAS Fellow, Director Yale Center for Molecular Discovery, Lab of Invention of FDA-approved drug Carfilzomib/KyprolisTM), Yale University 2004