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Jennifer Jonason, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-5608

Fax: (585) 275-1121

Biography

Research

The Jonason laboratory is interested in the signaling mechanisms that govern mesenchymal stem cell differentiation as well as maturation of committed chondrocytes and osteoblasts during skeletal development. Additionally, we have a strong interest in those mechanisms that function to maintain articular chondrocytes and the integrity of the articular cartilage matrix. We combine in vivo genetic mouse models with in vitro tissue culture and molecular biology techniques to better understand the role of specific signaling pathways and transcription factors in regulation of bone and joint development as well as in the onset and progression of osteoarthritis.

Credentials

Faculty Appointments

Education

1999
BS | Otterbein College
Molecular Biology

2006
PhD | Yale University
Genetics

Awards

2011
Young Investigator Travel Award
Sponsor: CMSR Annual Symposium
Location: University of Rochester

2008
Forum on Metabolic Bone Disease Travel Award
Location: Endocrine Fellows Foundation

2007 - 2010
National Research Service Award
Location: University of Rochester

1999
Outstanding Honor's Thesis
Location: Otterbein College

1999
Oustanding Senior Research Project
Location: Otterbein College

1998 - 1999
Mortar Board National College Senior Honor Society
Location: Otterbein College

1995 - 1999
Otterbein Scholar Award
Location: Otterbein College

1995 - 1999
Endowed Scholar Award
Location: Otterbein College

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Publications

Journal Articles

5/2014
Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ. "Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment." Bone.. 2014 May 0; 62:79-89. Epub 2014 Feb 12.

2014
Jonason JH, O'Keefe RJ. "Isolation and culture of neonatal mouse calvarial osteoblasts." Methods in molecular biology.. 2014 1130:295-305.

12/15/2013
Gao L, Sheu TJ, Dong Y, Hoak DM, Zuscik MJ, Schwarz EM, Hilton MJ, O'Keefe RJ, Jonason JH. "TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages." Journal of cell science.. 2013 Dec 15; 126(Pt 24):5704-13. Epub 2013 Oct 21.

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