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Alan M. Grossfield, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-4193

Fax: (585) 275-6007

Research Labs

My lab's research is focused on understanding the stomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool.

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Biography

Research

My research interests revolve around the use of computer modeling to understand the structure and thermodynamics of biological molecules. In particular, I am most interested in understanding the biology and physics of lipid-protein interactions. These interactions underlie a fantastic array of biological processes, including cell-signaling by GPCRs and some immune reactions, specifically the action of antimicrobial peptides.

Credentials

Faculty Appointments

Publications

Journal Articles

1/11/2018
Thompson JL, Zhao Y, Stathopulos PB, Grossfield A, Shuttleworth TJ. "Phosphorylation-mediated structural changes within the SOAR domain of STIM1 enable specific activation of distinct Orai channels." The Journal of biological chemistry.. 2018 Jan 11; Epub 2018 Jan 11.

9/20/2017
Romo TD, Lewis AK, Braun AR, Grossfield A, Sachs JN. "Minimal Nucleation State of ?-Synuclein Is Stabilized by Dynamic Threonine-Water Networks." ACS chemical neuroscience. 2017 Sep 20; 8(9):1859-1864. Epub 2017 Jul 10.

2/14/2017
Aytenfisu AH, Spasic A, Grossfield A, Stern HA, Mathews DH. "Revised RNA Dihedral Parameters for the Amber Force Field Improve RNA Molecular Dynamics." Journal of chemical theory and computation.. 2017 Feb 14; 13(2):900-915. Epub 2017 Jan 24.

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