Skip to main content
Explore URMC

URMC Logo

menu

Alan M. Grossfield, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-4193

Fax: (585) 275-6007

Research Labs

My lab's research is focused on understanding the stomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool.

Visit Lab Website

Faculty Appointments

Biography

Research

My research interests revolve around the use of computer modeling to understand the structure and thermodynamics of biological molecules. In particular, I am most interested in understanding the biology and physics of lipid-protein interactions. These interactions underlie a fantastic array of biological processes, including cell-signaling by GPCRs and some immune reactions, specifically the action of antimicrobial peptides.

Publications

Journal Articles

3/2/2018
Thompson JL, Zhao Y, Stathopulos PB, Grossfield A, Shuttleworth TJ. "Phosphorylation-mediated structural changes within the SOAR domain of stromal interaction molecule 1 enable specific activation of distinct Orai channels." The Journal of biological chemistry.. 2018 Mar 2; 293(9):3145-3155. Epub 2018 Jan 11.

3/1/2018
Sur S, Romo TD, Grossfield A. "Selectivity and Mechanism of Fengycin, an Antimicrobial Lipopeptide, from Molecular Dynamics." The journal of physical chemistry. B. 2018 Mar 1; 122(8):2219-2226. Epub 2018 Feb 15.

1/23/2018
Salas-Estrada LA, Leioatts N, Romo TD, Grossfield A. "Lipids Alter Rhodopsin Function via Ligand-like and Solvent-like Interactions." Biophysical journal.. 2018 Jan 23; 114(2):355-367.

VIEW ALL PUBLICATIONS