Lei Xu, Ph.D.

Lei Xu, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 633
Rochester, NY 14642

Fax: (585) 273-1450
Office: (585) 273-1302
Administrative: (585) 273-1440
Lab: (585) 276-4365

Research Bio

The Xu laboratory investigates the mechanism of metastasis, the spread of cancer cells from their original loci to other parts of the body. It is the major cause of death in cancer patients, but exactly how it occurs is not clear. Metastasis involves multiple levels of interactions between migrating tumor cells and their microenvironment. Understanding these interactions will greatly enhance our knowledge on metastasis and lead to a better treatment of cancer. A major focus of the laboratory is thus to dissect these interactions by studying the functions of cell surface molecules during tumor spread. Knockout mice, mouse cancer models, as well as various biochemical and bioinformatics tools are used in the laboratory.

Awards & Honors (Local)

IDEA Award from NYSTEM | New York State Department of Health 2009
Ruth L. Kirschstein National Research Service Award | NIH 2009
Gold Medal | Nanjing University, China 1992
Excellent Student Award | Nanjing University, China 1992 - 1994
Guanghua Award | Nanjing University, China 1991

Recent Journal Articles

Showing the 5 most recent journal articles. 12 available »

2012 Apr
Yang L, Xu L. "GPR56 in cancer progression: current status and future perspective." Future oncology. 2012 Apr; 8(4):431-40.
Liquan Yang; Guangchun Chen; Sonali Mohanty; Glynis Scott; Febeha Fazal; Arshad Rahman; Shahinoor Begum; Richard O. Hynes; Lei Xu. "GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression." Cancer Research. 2011; 71: 5558-68.
Lei Xu; Shahinoor Begum; Marc Barry; Denise Crowley; Liquan Yang; Roderick T. Bronson; Richard O. Hynes. "GPR56 Plays Varying Roles in Endogenous Cancer Progression". Clinical and Experimental Metastasis. 2010; 27: 241-9.
Guangchun Chen; Liquan Yang; Shahinoor Begum; Lei Xu. "GPR56 Is Essential for Testis Development and Male Fertility in Mice." Developmental Dynamics. 2010; 239: 3358-67.
2008 May
Xu L, Shen SS, Hoshida Y, Subramanian A, Ross K, Brunet JP, Wagner SN, Ramaswamy S, Mesirov JP, Hynes RO. "Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases." Molecular cancer research : MCR. 2008 May; 6(5):760-9.

Current Appointments

Associate Professor - Department of Biomedical Genetics (SMD) - Primary


Postdoctoral Training | Massachusetts Institute of Technology2007
Ph.D. | Biological Sciences | Indiana University2000
B.S. | Biochemistry | Nanjing University1994

Post-Doctoral Training & Residency

Massachusetts Institute of Technology, Cancer Biology (Mentor: Richard Hynes) 2007