Lei Xu, Ph.D.

Lei Xu, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 633
Rochester, NY 14642

Fax: (585) 273-1450
Office: (585) 273-1302
Administrative: (585) 273-1440
Lab: (585) 276-4365

Journal Articles

Showing all 23 journal articles available.

Tiwary S, Xu L. "FRIZZLED7 Is Required for Tumor Inititation and Metastatic Growth of Melanoma Cells." PloS one. 2016 11(1):e0147638. Epub 2016 Jan 25.
2015 May 12
Stoveken HM, Hajduczok AG, Xu L, Tall GG. "Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist." Proceedings of the National Academy of Sciences of the United States of America. 2015 May 12; 112(19):6194-9. Epub 2015 Apr 27.
Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB. "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors." Pharmacological reviews. 2015 67(2):338-67.
2014 Dec
Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. "New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors." Annals of the New York Academy of Sciences. 2014 Dec; 1333:43-64. Epub 2014 Nov 25.
2014 Jul 7
Tiwary S, Preziosi M, Rothberg PG, Zeitouni N, Corson N, Xu L. "ERBB3 is required for metastasis formation of melanoma cells." Oncogenesis. 2014 Jul 7; 3:e110. Epub 2014 Jul 07.
2014 Feb 15
Yang L, Friedland S, Corson N, Xu L. "GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2." Cancer research. 2014 Feb 15; 74(4):1022-31. Epub 2013 Dec 19.
2013 Oct 10
Chen Y, Soong J, Mohanty S, Xu L, Scott G. "The neural guidance receptor Plexin C1 delays melanoma progression." Oncogene. 2013 Oct 10; 32(41):4941-9. Epub 2012 Nov 19.
2012 Dec
Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T. "Dissecting signaling and functions of adhesion G protein-coupled receptors." Annals of the New York Academy of Sciences. 2012 Dec; 1276:1-25. Epub 2012 Dec 07.
2012 Apr
Yang L, Xu L. "GPR56 in cancer progression: current status and future perspective." Future oncology. 2012 Apr; 8(4):431-40.
2011 Aug 15
Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A, Begum S, Hynes R, Xu L. "GPR56 Regulates VEGF production and angiogenesis during melanoma progression." Cancer research. 2011 Aug 15; 71(16):5558-68. Epub 2011 Jul 01.
2011 May
Dimond P, Carlson K, Bouvier M, Gerard C, Xu L, Covic L, Agarwal A, Ernst OP, Janz JM, Schwartz TW, Gardella TJ, Milligan G, Kuliopulos A, Sakmar TP, Hunt SW. "G protein-coupled receptor modulation with pepducins: moving closer to the clinic." Annals of the New York Academy of Sciences. 2011 May; 1226:34-49.
2010 Aug 24
Mohanty S, Xu L. "Experimental metastasis assay." Journal of visualized experiments : JoVE. 2010 Aug 24; (42)Epub 2010 Aug 24.
2010 Apr
Xu L, Begum S, Barry M, Crowley D, Yang L, Bronson RT, Hynes RO. "GPR56 plays varying roles in endogenous cancer progression." Clinical & experimental metastasis. 2010 Apr; 27(4):241-9. Epub 2010 Mar 24.
Guangchun Chen; Liquan Yang; Shahinoor Begum; Lei Xu. "GPR56 Is Essential for Testis Development and Male Fertility in Mice." Developmental Dynamics. 2010; 239: 3358-67.
Xu L. "GPR56 interacts with extracellular matrix and regulates cancer progression." Advances in experimental medicine and biology. 2010 706:98-108.
2008 May 28
Li S, Jin Z, Koirala S, Bu L, Xu L, Hynes RO, Walsh CA, Corfas G, Piao X. "GPR56 regulates pial basement membrane integrity and cortical lamination." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 May 28; 28(22):5817-26.
2008 May
Xu L, Shen SS, Hoshida Y, Subramanian A, Ross K, Brunet JP, Wagner SN, Ramaswamy S, Mesirov JP, Hynes RO. "Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases." Molecular cancer research : MCR. 2008 May; 6(5):760-9.
2007 Jan 15
Xu L, Hynes RO. "GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment." Cell cycle. 2007 Jan 15; 6(2):160-5. Epub 2007 Jan 28.
2006 Jun 13
Xu L, Begum S, Hearn JD, Hynes RO. "GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis." Proceedings of the National Academy of Sciences of the United States of America. 2006 Jun 13; 103(24):9023-8. Epub 2006 Jun 06.
2001 Nov
Xu L, Paulsen J, Yoo Y, Goodwin EB, Strome S. "Caenorhabditis elegans MES-3 is a target of GLD-1 and functions epigenetically in germline development." Genetics. 2001 Nov; 159(3):1007-17.
2001 Nov
Xu L, Strome S. "Depletion of a novel SET-domain protein enhances the sterility of mes-3 and mes-4 mutants of Caenorhabditis elegans." Genetics. 2001 Nov; 159(3):1019-29.
2001 Apr 24
Xu L, Fong Y, Strome S. "The Caenorhabditis elegans maternal-effect sterile proteins, MES-2, MES-3, and MES-6, are associated in a complex in embryos." Proceedings of the National Academy of Sciences of the United States of America. 2001 Apr 24; 98(9):5061-6.
1999 Jan
Williams C, Xu L, Blumenthal T. "SL1 trans splicing and 3'-end formation in a novel class of Caenorhabditis elegans operon." Molecular and cellular biology. 1999 Jan; 19(1):376-83.


Lei Xu. "GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression.". Adhesion-GPCRs. : Landes Biosciences, 2010.