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Lei Xu, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 273-1440

Appointment: (585) 273-1302

Fax: (585) 273-1450

Office: (585) 273-1302

Research Labs

Biography

Research

The Xu laboratory investigates the mechanism of metastasis, the spread of cancer cells from their original loci to other parts of the body. It is the major cause of death in cancer patients, but exactly how it occurs is not clear. Metastasis involves multiple levels of interactions between migrating tumor cells and their microenvironment. Understanding these interactions will greatly enhance our knowledge on metastasis and lead to a better treatment of cancer. A major focus of the laboratory is to dissect these interactions by studying the functions of a new family of cell surface receptors, called adhesion G protein-coupled receptors (GPCRs), during tumor spread. One of the adhesion GPCRs, GPR56, was found to play inhibitory roles in metastatic growth of melanoma cells. We explore its regulatory mechanisms using xenograft models, knockout mice, transgenic tumor models, as well as various biochemical and bioinformatics tools.

Credentials

Faculty Appointments

Education

2000
Ph.D. | Indiana University
Biological Sciences

1994
B.S. | Nanjing University
Biochemistry

2007
Postdoctoral Training | Massachusetts Institute of Technology

Awards

2009
IDEA Award from NYSTEM
Sponsor: New York State Department of Health

2009
Ruth L. Kirschstein National Research Service Award
Sponsor: NIH

1992 - 1994
Excellent Student Award
Sponsor: Nanjing University, China

1992
Gold Medal
Sponsor: Nanjing University, China

1991
Guanghua Award
Sponsor: Nanjing University, China

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Publications

Journal Articles

10/2016
Chandrasekaran S, Giang UB, Xu L, DeLouise LA. "In vitro assays for determining the metastatic potential of melanoma cell lines with characterized in vivo invasiveness." Biomedical microdevices.. 2016 Oct 0; 18(5):89.

2016
Tiwary S, Xu L. "FRIZZLED7 Is Required for Tumor Inititation and Metastatic Growth of Melanoma Cells." PloS one. 2016 11(1):e0147638. Epub 2016 Jan 25.

5/12/2015
Stoveken HM, Hajduczok AG, Xu L, Tall GG. "Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist." Proceedings of the National Academy of Sciences of the United States of America.. 2015 May 12; 112(19):6194-9. Epub 2015 Apr 27.

Books & Chapters

2010
Chapter Title: GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression.
Book Title: Adhesion-GPCRs
Author List: Lei Xu
Published By: Landes Biosciences2010

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