Xia Jin, B.Med., Ph.D.

Xia Jin, B.Med., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 689
Rochester, NY 14642

Office: (585) 275-6515
Lab: (585) 275-5775
Administrative: (585) 275-5871
Fax: (585) 442-9328

Journal Articles

Showing all 62 journal articles available.

2012 Feb
Miao H, Jin X, Perelson AS, Wu H. "Evaluation of multitype mathematical models for CFSE-labeling experiment data." Bulletin of mathematical biology. 2012 Feb; 74(2):300-26. Epub 2011 Jun 17.
Kobie JJ, Alcena DC, Zheng B, Bryk P, Mattiacio JL, Brewer M, Labranche C, Young FM, Dewhurst S, Montefiori DC, Rosenberg AF, Feng C, Jin X, Keefer MC, Sanz I. "9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity." PloS one. 2012 7(4):e35356. Epub 2012 Apr 18.
2011 Feb 24
Keefer MC, Frey SE, Elizaga M, Metch B, De Rosa SC, Barroso PF, Tomaras G, Cardinali M, Goepfert P, Kalichman A, Philippon V, McElrath MJ, Jin X, Ferrari G, Defawe OD, Mazzara GP, Montefiori D, Pensiero M, Panicali DL, Corey L, . "A phase I trial of preventive HIV vaccination with heterologous poxviral-vectors containing matching HIV-1 inserts in healthy HIV-uninfected subjects." Vaccine. 2011 Feb 24; 29(10):1948-58. Epub 2011 Jan 07.
2011 Feb 5
Kou Z, Lim JY, Beltramello M, Quinn M, Chen H, Liu SN, Martnez-Sobrido L, Diamond MS, Schlesinger JJ, de Silva A, Sallusto F, Jin X. "Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes." Virology. 2011 Feb 5; 410(1):240-7. Epub 2010 Dec 04.
Zhihua Kou; Joanne Y. H. Lim; Martina Beltramello; Matthew Quinn; Huiyuan Chen; Shengyoung Liu; Luis Martnez-Sobrido; Michael S. Diamond;Jacob J. Schlesinger; Aravinda de Silva; Federica Sallusto; and Xia Jin. "Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes". Virology. 2011; 410: 240-247.
Spyros A. Kalams; Scott Parker; Marnie Elizaga; Barbara Metch; Maggie Wang; Elizabeth Adams; John Hural; Michael Lubeck; Ralph Braun; John Eldridge; Massimo Cardinali; Xia Jin; William A. Blattner; Beryl Koblin; Vinai Suriyanon; Arturo Kalichman; Lindsey Baden; and the NIAID HIV Vaccine Trials Network. "Safety and Immunogenicity of an HIV-1 Gag DNA vaccine with or without IL-12 or IL-15 plasmid cytokine adjuvant in healthy, HIV-1 uninfected adult participants". PLoS ONE. 2011; : In Review.
Saima J Ansari; Matthew L Ferrantino; James Cavanaugh; Changyong Feng; Xia Jin; Edward E Walsh; Tim R Mosmann; F. Eun-Hyung Lee. "RSV- and Influenza-specific IFN? Responses are Novel Biomarkers that Can Predict Opportunistic Infection Risk in HIV+ patients". JAIDS. 2011; : In Review.
Arevalo, M.T.; Simpson-Haidaris, P.J.; Chen, HY; Quinn, M.; Huang, C.Y-H; Jin, X. "Syndecans mediate dengue viral infection of humanvascular endothelial cells". Journal of Virology. 2011; : In Review.
Liao, B-L; Tang, Y-B; Hu, F-Y; Zhou, W-Z; Yao, X.; Hong, W-X; Wang J.; Zhang, X-Y; Tang, X-P; Jin, X.; Zhang, F-C. "Soluble vascular cell adhesion molecule-1 (sVCAM-1) is a biomarker for severe dengue fever in DENV-1 infected adults". The Journal of Infectious Diseases. 2011; : In Review.
2010 Nov 29
Block OK, Rodrigo WW, Quinn M, Jin X, Rose RC, Schlesinger JJ. "A tetravalent recombinant dengue domain III protein vaccine stimulates neutralizing and enhancing antibodies in mice." Vaccine. 2010 Nov 29; 28(51):8085-94. Epub 2010 Oct 16.
Wang, J.; Jin, X. "HIV vaccine could use a little help". Human Vaccine. 2010; 6(6): 1-6.
Yangbo Tang; Zhihua Kou;Fuchun Zhang;Xian Yao; Shengyong Liu; Jingming Ma; Yusen Zhou; Wei Zhao; Xiaoping Tang; and Xia Jin. "Both viremia and cytokine levels associate with the lack of severe disease in secondary dengue 1 infection among adult Chinese patients". PLoS ONE. 2010; 5(12): e15631.
2009 Nov 25
Rodrigo WW, Block OK, Lane C, Sukupolvi-Petty S, Goncalvez AP, Johnson S, Diamond MS, Lai CJ, Rose RC, Jin X, Schlesinger JJ. "Dengue virus neutralization is modulated by IgG antibody subclass and Fcgamma receptor subtype." Virology. 2009 Nov 25; 394(2):175-82. Epub 2009 Oct 14.
2009 Nov 23
Jin X, Newman MJ, De-Rosa S, Cooper C, Thomas E, Keefer M, Fuchs J, Blattner W, Livingston BD, McKinney DM, Noonan E, Decamp A, Defawe OD, Wecker M, . "A novel HIV T helper epitope-based vaccine elicits cytokine-secreting HIV-specific CD4+ T cells in a Phase I clinical trial in HIV-uninfected adults." Vaccine. 2009 Nov 23; 27(50):7080-6. Epub 2009 Sep 26.
2009 Sep 1
Li H, Chen X, Jin X, Liu Z, Huang X, Cao Z, Guo C, Dong T, Wu H. "Proliferation, but not interleukin 2 production, of Gag-specific CD8+ T cells is associated with low HIV viremia and high CD4 counts in HIV-1-infected Chinese individuals." Journal of acquired immune deficiency syndromes : JAIDS. 2009 Sep 1; 52(1):1-8.
2009 Jul
Lee HY, Topham DJ, Park SY, Hollenbaugh J, Treanor J, Mosmann TR, Jin X, Ward B, Miao H, Holden-Wiltse J, Perelson AS, Zand M, Wu H. "Simulation and prediction of the adaptive immune response to influenza A virus infection." Journal of virology. 2009 Jul; 83(14):7151-65. Epub 2009 May 13.
2009 Mar
Arévalo MT, Simpson-Haidaris PJ, Kou Z, Schlesinger JJ, Jin X. "Primary human endothelial cells support direct but not antibody-dependent enhancement of dengue viral infection." Journal of medical virology. 2009 Mar; 81(3):519-28.
2009 Feb
Rodrigo WW, Alcena DC, Kou Z, Kochel TJ, Porter KR, Comach G, Rose RC, Jin X, Schlesinger JJ. "Difference between the abilities of human Fcgamma receptor-expressing CV-1 cells to neutralize American and Asian genotypes of dengue virus 2." Clinical and vaccine immunology : CVI. 2009 Feb; 16(2):285-7. Epub 2008 Nov 26.
2009 Jan
Shanaka WW, Rodrigo I, Alcena DC, Rose RC, Jin X, Schlesinger JJ. "An automated Dengue virus microneutralization plaque assay performed in human Fc{gamma} receptor-expressing CV-1 cells." The American journal of tropical medicine and hygiene. 2009 Jan; 80(1):61-5.
Jin X, Block OT, Rose R, Schlesinger J. "Dengue vaccine development and dengue viral neutralization and enhancement assays." Antiviral therapy. 2009 14(6):739-49.
2008 Aug
Caserta MT, O'Connor TG, Wyman PA, Wang H, Moynihan J, Cross W, Tu X, Jin X. "The associations between psychosocial stress and the frequency of illness, and innate and adaptive immune function in children." Brain, behavior, and immunity. 2008 Aug; 22(6):933-40. Epub 2008 Mar 04.
2008 Aug
Tang Y, Kou Z, Tang X, Zhang F, Yao X, Liu S, Jin X. "Unique impacts of HBV co-infection on clinical and laboratory findings in a recent dengue outbreak in China." The American journal of tropical medicine and hygiene. 2008 Aug; 79(2):154-8.
2008 Jan
Kou Z, Quinn M, Chen H, Rodrigo WW, Rose RC, Schlesinger JJ, Jin X. "Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells." Journal of medical virology. 2008 Jan; 80(1):134-46.
Xia Jin. "Cellular and molecular basis antibody-dependent enhancement in human dengue pathogenesis". Future Virology. 2008; 3(4): 343-361.
2007 Mar
Wyman PA, Moynihan J, Eberly S, Cox C, Cross W, Jin X, Caserta MT. "Association of family stress with natural killer cell activity and the frequency of illnesses in children." Archives of pediatrics & adolescent medicine. 2007 Mar; 161(3):228-34.
Jin X, Wu H, Smith H. "APOBEC3G levels predict rates of progression to AIDS." Retrovirology. 2007 4:20. Epub 2007 Mar 20.
Blackley S, Kou Z, Chen H, Quinn M, Rose RC, Schlesinger JJ, Coppage M, Jin X. "Primary human splenic macrophages, but not T or B cells, are the principal target cells for dengue virus infection in vitro." Journal of virology. 2007 81(24):13325-34. Epub 2007 Oct 10.
2006 Oct
Rodrigo WW, Jin X, Blackley SD, Rose RC, Schlesinger JJ. "Differential enhancement of dengue virus immune complex infectivity mediated by signaling-competent and signaling-incompetent human Fcgamma RIA (CD64) or FcgammaRIIA (CD32)." Journal of virology. 2006 Oct; 80(20):10128-38.
2006 Sep
Yu J, Chen H, Horton H, Bansal A, McElrath JM, Reichman R, Goepfert P, Jin X. "Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection." Journal of medical virology. 2006 Sep; 78(9):1147-57.
2006 Jun
Dykes C, Wang J, Jin X, Planelles V, An DS, Tallo A, Huang Y, Wu H, Demeter LM. "Evaluation of a multiple-cycle, recombinant virus, growth competition assay that uses flow cytometry to measure replication efficiency of human immunodeficiency virus type 1 in cell culture." Journal of clinical microbiology. 2006 Jun; 44(6):1930-43.
2006 May 30
Liu D, Yu J, Chen H, Reichman R, Wu H, Jin X. "Statistical determination of threshold for cellular division in the CFSE-labeling assay." Journal of immunological methods. 2006 May 30; 312(1-2):126-36. Epub 2006 May 02.
2006 Feb 15
Snyder-Cappione JE, Divekar AA, Maupin GM, Jin X, Demeter LM, Mosmann TR. "HIV-specific cytotoxic cell frequencies measured directly ex vivo by the Lysispot assay can be higher or lower than the frequencies of IFN-gamma-secreting cells: anti-HIV cytotoxicity is not generally impaired relative to other chronic virus responses." The Journal of immunology : official journal of the American Association of Immunologists. 2006 Feb 15; 176(4):2662-8.
2005 Sep
Jin X, Brooks A, Chen H, Bennett R, Reichman R, Smith H. "APOBEC3G/CEM15 (hA3G) mRNA levels associate inversely with human immunodeficiency virus viremia." Journal of virology. 2005 Sep; 79(17):11513-6.
2005 Feb
Chen H, Reichman R, Keefer M, McDermott MP, Jin X. "Establishment of an alternative intracellular cytokine staining assay for HIV/AIDS clinical studies." Journal of virological methods. 2005 Feb; 123(2):131-40.
Metzner KJ, Moretto WJ, Donahoe SM, Jin X, Gettie A, Montefiori DC, Marx PA, Binley JM, Nixon DF, Connor RI. "Evaluation of CD8+ T-cell and antibody responses following transient increased viraemia in rhesus macaques infected with live, attenuated simian immunodeficiency virus." The Journal of general virology. 2005 86(Pt 12):3375-84.
2003 Jul
Wang X, Messerle M, Sapinoro R, Santos K, Hocknell PK, Jin X, Dewhurst S. "Murine cytomegalovirus abortively infects human dendritic cells, leading to expression and presentation of virally vectored genes." Journal of virology. 2003 Jul; 77(13):7182-92.
2002 Sep 1
Markowitz M, Jin X, Hurley A, Simon V, Ramratnam B, Louie M, Deschenes GR, Ramanathan M, Barsoum S, Vanderhoeven J, He T, Chung C, Murray J, Perelson AS, Zhang L, Ho DD. "Discontinuation of antiretroviral therapy commenced early during the course of human immunodeficiency virus type 1 infection, with or without adjunctive vaccination." The Journal of infectious diseases. 2002 Sep 1; 186(5):634-43. Epub 2002 Aug 09.
2002 Mar
Jin X, Ramanathan M, Barsoum S, Deschenes GR, Ba L, Binley J, Schiller D, Bauer DE, Chen DC, Hurley A, Gebuhrer L, El Habib R, Caudrelier P, Klein M, Zhang L, Ho DD, Markowitz M. "Safety and immunogenicity of ALVAC vCP1452 and recombinant gp160 in newly human immunodeficiency virus type 1-infected patients treated with prolonged highly active antiretroviral therapy." Journal of virology. 2002 Mar; 76(5):2206-16.
Jin X, Gao X, Ramanathan M, Deschenes GR, Nelson GW, O'Brien SJ, Goedert JJ, Ho DD, O'Brien TR, Carrington M. "Human immunodeficiency virus type 1 (HIV-1)-specific CD8+-T-cell responses for groups of HIV-1-infected individuals with different HLA-B*35 genotypes." Journal of virology. 2002 76(24):12603-10.
2001 Nov 1
Cherpelis S, Jin X, Gettie A, Ho DD, Barnett SW, Shrivastava I, Stamatatos L. "DNA-immunization with a V2 deleted HIV-1 envelope elicits protective antibodies in macaques." Immunology letters. 2001 Nov 1; 79(1-2):47-55.
2001 Feb
Cherpelis S, Shrivastava I, Gettie A, Jin X, Ho DD, Barnett SW, Stamatatos L. "DNA vaccination with the human immunodeficiency virus type 1 SF162DeltaV2 envelope elicits immune responses that offer partial protection from simian/human immunodeficiency virus infection to CD8(+) T-cell-depleted rhesus macaques." Journal of virology. 2001 Feb; 75(3):1547-50.
2000 Oct
Zhang L, Chung C, Hu BS, He T, Guo Y, Kim AJ, Skulsky E, Jin X, Hurley A, Ramratnam B, Markowitz M, Ho DD. "Genetic characterization of rebounding HIV-1 after cessation of highly active antiretroviral therapy." The Journal of clinical investigation. 2000 Oct; 106(7):839-45.
2000 Sep
Jin X, Ogg G, Bonhoeffer S, Safrit J, Vesanen M, Bauer D, Chen D, Cao Y, Demoitie MA, Zhang L, Markowitz M, Nixon D, McMichael A, Ho DD. "An antigenic threshold for maintaining human immunodeficiency virus type 1-specific cytotoxic T lymphocytes." Molecular medicine. 2000 Sep; 6(9):803-9.
2000 Jun 5
Metzner KJ, Jin X, Lee FV, Gettie A, Bauer DE, Di Mascio M, Perelson AS, Marx PA, Ho DD, Kostrikis LG, Connor RI. "Effects of in vivo CD8(+) T cell depletion on virus replication in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine." The Journal of experimental medicine. 2000 Jun 5; 191(11):1921-31.
2000 Jan 1
Jin X, Roberts CG, Nixon DF, Safrit JT, Zhang LQ, Huang YX, Bhardwaj N, Jesdale B, DeGroot AS, Koup RA. "Identification of subdominant cytotoxic T lymphocyte epitopes encoded by autologous HIV type 1 sequences, using dendritic cell stimulation and computer-driven algorithm." AIDS research and human retroviruses. 2000 Jan 1; 16(1):67-76.
2000 Jan
Jin X, Demoitie MA, Donahoe SM, Ogg GS, Bonhoeffer S, Kakimoto WM, Gillespie G, Moss PA, Dyer W, Kurilla MG, Riddell SR, Downie J, Sullivan JS, McMichael AJ, Workman C, Nixon DF. "High frequency of cytomegalovirus-specific cytotoxic T-effector cells in HLA-A*0201-positive subjects during multiple viral coinfections." The Journal of infectious diseases. 2000 Jan; 181(1):165-75.
1999 Sep 6
Zhang L, Lewin SR, Markowitz M, Lin HH, Skulsky E, Karanicolas R, He Y, Jin X, Tuttleton S, Vesanen M, Spiegel H, Kost R, van Lunzen J, Stellbrink HJ, Wolinsky S, Borkowsky W, Palumbo P, Kostrikis LG, Ho DD. "Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy." The Journal of experimental medicine. 1999 Sep 6; 190(5):725-32.
1999 Sep
Ortiz GM, Nixon DF, Trkola A, Binley J, Jin X, Bonhoeffer S, Kuebler PJ, Donahoe SM, Demoitie MA, Kakimoto WM, Ketas T, Clas B, Heymann JJ, Zhang L, Cao Y, Hurley A, Moore JP, Ho DD, Markowitz M. "HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy." The Journal of clinical investigation. 1999 Sep; 104(6):R13-8.
1999 May 7
Larsson M, Jin X, Ramratnam B, Ogg GS, Engelmayer J, Demoitie MA, McMichael AJ, Cox WI, Steinman RM, Nixon D, Bhardwaj N. "A recombinant vaccinia virus based ELISPOT assay detects high frequencies of Pol-specific CD8 T cells in HIV-1-positive individuals." AIDS. 1999 May 7; 13(7):767-77.
1999 Mar 15
Jin X, Bauer DE, Tuttleton SE, Lewin S, Gettie A, Blanchard J, Irwin CE, Safrit JT, Mittler J, Weinberger L, Kostrikis LG, Zhang L, Perelson AS, Ho DD. "Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques." The Journal of experimental medicine. 1999 Mar 15; 189(6):991-8.
1999 Mar
Markowitz M, Vesanen M, Tenner-Racz K, Cao Y, Binley JM, Talal A, Hurley A, Jin X, Chaudhry MR, Yaman M, Frankel S, Heath-Chiozzi M, Leonard JM, Moore JP, Racz P, Nixon DF, Ho DD, J X. "The effect of commencing combination antiretroviral therapy soon after human immunodeficiency virus type 1 infection on viral replication and antiviral immune responses." The Journal of infectious diseases. 1999 Mar; 179(3):527-37.
1999 Mar
Kakimoto WM, Gettie A, Smith S, Donahoe SM, Jin X, Marx P, Connor R, Nixon DF. "Comparison of restimulation methods to elicit SIV specific cytotoxic T-lymphocytes (CTL) in vitro: Staphylococcal enterotoxin B (SEB) provides a novel method for the quantification of SIV specific CTL precursors." Immunology letters. 1999 Mar; 66(1-3):135-40.
1999 Mar
Nixon DF, Douek D, Kuebler PJ, Jin X, Vesanen M, Bonhoeffer S, Cao Y, Koup RA, Ho DD, Markowitz M. "Molecular tracking of an Human Immunodeficiency Virus nef specific cytotoxic T-cell clone shows persistence of clone-specific T-cell receptor DNA but not mRNA following early combination antiretroviral therapy." Immunology letters. 1999 Mar; 66(1-3):219-28.
1999 Jan
Dyer WB, Ogg GS, Demoitie MA, Jin X, Geczy AF, Rowland-Jones SL, McMichael AJ, Nixon DF, Sullivan JS. "Strong human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte activity in Sydney Blood Bank Cohort patients infected with nef-defective HIV type 1." Journal of virology. 1999 Jan; 73(1):436-43.
1999 Jan
Ogg GS, Jin X, Bonhoeffer S, Moss P, Nowak MA, Monard S, Segal JP, Cao Y, Rowland-Jones SL, Hurley A, Markowitz M, Ho DD, McMichael AJ, Nixon DF. "Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy." Journal of virology. 1999 Jan; 73(1):797-800.
1998 Nov
Jin X, Roberts CG, Nixon DF, Cao Y, Ho DD, Walker BD, Muldoon M, Korber BT, Koup RA. "Longitudinal and cross-sectional analysis of cytotoxic T lymphocyte responses and their relationship to vertical human immunodeficiency virus transmission. ARIEL Project Investigators." The Journal of infectious diseases. 1998 Nov; 178(5):1317-26.
1998 Nov
Jin X, Wills M, Sissons JG, Carmichael A. "Progressive loss of IL-2-expandable HIV-1-specific cytotoxic T lymphocytes during asymptomatic HIV infection." European journal of immunology. 1998 Nov; 28(11):3564-76.
1998 Apr
Binley JM, Jin X, Huang Y, Zhang L, Cao Y, Ho DD, Moore JP. "Persistent antibody responses but declining cytotoxic T-lymphocyte responses to multiple human immunodeficiency virus type 1 antigens in a long-term nonprogressing individual with a defective p17 proviral sequence and no detectable viral RNA expression." Journal of virology. 1998 Apr; 72(4):3472-4.
1998 Mar 27
Ogg GS, Jin X, Bonhoeffer S, Dunbar PR, Nowak MA, Monard S, Segal JP, Cao Y, Rowland-Jones SL, Cerundolo V, Hurley A, Markowitz M, Ho DD, Nixon DF, McMichael AJ. "Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA." Science. 1998 Mar 27; 279(5359):2103-6.
1996 Nov
Wills MR, Carmichael AJ, Mynard K, Jin X, Weekes MP, Plachter B, Sissons JG. "The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL." Journal of virology. 1996 Nov; 70(11):7569-79.
Carmichael A, Jin X, Sissons P. "Analysis of the human env-specific cytotoxic T-lymphocyte (CTL) response in natural human immunodeficiency virus type 1 infection: low prevalence of broadly cross-reactive env-specific CTL." Journal of virology. 1996 70(12):8468-76.
1993 Feb 1
Carmichael A, Jin X, Sissons P, Borysiewicz L. "Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease." The Journal of experimental medicine. 1993 Feb 1; 177(2):249-56.


Xia Jin. "Quantitative comparison of the human immunodeficiency virus 1 and Epstein-Barr virus specific cytotoxic T lymphocyte responses". PhD Thesis. : Open University, England, 1995.