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Soo Ok Lee, Ph.D.


Showing all 62 journal articles & 0 books available

Journal Articles

Wen S, Niu Y, Lee SO, Yeh S, Shang Z, Gao H, Li Y, Chou F, Chang C. "Targeting fatty acid synthase with ASC-J9 suppresses proliferation and invasion of prostate cancer cells." Molecular carcinogenesis.. 2016 Dec 0; 55(12):2278-2290. Epub 2016 Feb 19.

Zhang F, Duan S, Tsai Y, Keng P, Chen Y, Lee SO, Chen Y. "Cisplatin treatment increases stemness through upregulation of hypoxia-inducible factors by interleukin-6 in non-small cell lung cancer." Cancer science.. 2016 Jun 0; 107(6):746-54. Epub 2016 May 03.

Huang CK, Lee SO, Chang E, Pang H, Chang C. "Androgen receptor (AR) in cardiovascular diseases." The Journal of endocrinology.. 2016 Apr 0; 229(1):R1-R16. Epub 2016 Jan 14.

Lee SO, Yang X, Duan S, Tsai Y, Strojny LR, Keng P, Chen Y. "IL-6 promotes growth and epithelial-mesenchymal transition of CD133+ cells of non-small cell lung cancer." Oncotarget. 2016 Feb 9; 7(6):6626-38.

Yang L; Zhang F; Wang X; Tsai Y; Chuang KH; Keng PC; Lee SO; Chen Y. "A FASN-TGF-?1-FASN regulatory loop contributes to high EMT/metastatic potential of cisplatin-resistant non-small cell lung cancer". Oncotarget. 2016; 7(34): 55543-55554.

Chen Y, Zhang F, Tsai Y, Yang X, Yang L, Duan S, Wang X, Keng P, Lee SO. "IL-6 signaling promotes DNA repair and prevents apoptosis in CD133+ stem-like cells of lung cancer after radiation." Radiation oncology. 2015 Nov 14; 10:227. Epub 2015 Nov 14.

Huang CK, Luo J, Lai KP, Wang R, Pang H, Chang E, Yan C, Sparks J, Lee SO, Cho J, Chang C. "Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1? and transforming growth factor-?1 expression." Hypertension.. 2015 Oct 0; 66(4):881-91.

Duan S, Tsai Y, Keng P, Chen Y, Lee SO, Chen Y. "IL-6 signaling contributes to cisplatin resistance in non-small cell lung cancer via the up-regulation of anti-apoptotic and DNA repair associated molecules." Oncotarget. 2015 Sep 29; 6(29):27651-60.

Luo J, Lee SO, Cui Y, Yang R, Li L, Chang C. "Infiltrating bone marrow mesenchymal stem cells (BM-MSCs) increase prostate cancer cell invasion via altering the CCL5/HIF2?/androgen receptor signals." Oncotarget. 2015 Sep 29; 6(29):27555-65.

Ding X, Yang DR, Lee SO, Chen YL, Xia LQ, Lin SJ, Yu SC, Niu YJ, Li G, Chang C. "TR4 nuclear receptor promotes prostate cancer metastasis via upregulation of CCL2/CCR2 signaling." International journal of cancer.. 2015 Feb 15; 136(4):955-64. Epub 2014 Jul 14.

Huang CK, Luo J, Lee SO, Chang C. "Concise review: androgen receptor differential roles in stem/progenitor cells including prostate, embryonic, stromal, and hematopoietic lineages." Stem cells.. 2014 Sep 0; 32(9):2299-308.

Liang L, Li L, Tian J, Lee SO, Dang Q, Huang CK, Yeh S, Erturk E, Bushinsky D, Chang LS, He D, Chang C. "Androgen receptor enhances kidney stone-CaOx crystal formation via modulation of oxalate biosynthesis & oxidative stress." Molecular endocrinology.. 2014 Aug 0; 28(8):1291-303. Epub 2014 Jun 23.

Chang C, Lee SO, Yeh S, Chang TM. "Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver." Oncogene.. 2014 Jun 19; 33(25):3225-34. Epub 2013 Jul 22.

Lin SJ, Lee SO, Lee YF, Miyamoto H, Yang DR, Li G, Chang C. "TR4 nuclear receptor functions as a tumor suppressor for prostate tumorigenesis via modulation of DNA damage/repair system." Carcinogenesis.. 2014 Jun 0; 35(6):1399-406. Epub 2014 Feb 28.

Huang CK, Pang H, Wang L, Niu Y, Luo J, Chang E, Sparks JD, Lee SO, Chang C. "New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis." Hypertension.. 2014 Jun 0; 63(6):1345-53. Epub 2014 Mar 31.

Luo J, Ok Lee S, Liang L, Huang CK, Li L, Wen S, Chang C. "Infiltrating bone marrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling." Oncogene.. 2014 May 22; 33(21):2768-78. Epub 2013 Jun 24.

Wen S, Niu Y, Lee SO, Chang C. "Androgen receptor (AR) positive vs negative roles in prostate cancer cell deaths including apoptosis, anoikis, entosis, necrosis and autophagic cell death." Cancer treatment reviews.. 2014 Feb 0; 40(1):31-40. Epub 2013 Aug 07.

Soh SF, Huang CK, Lee SO, Xu D, Yeh S, Li J, Yong EL, Gong Y, Chang C. "Determination of androgen receptor degradation enhancer ASC-J9(®) in mouse sera and organs with liquid chromatography tandem mass spectrometry." Journal of pharmaceutical and biomedical analysis.. 2014 Jan 0; 88:117-22. Epub 2013 Aug 27.

Chen Y, Nowak I, Huang J, Keng PC, Sun H, Xu H, Wei G, Lee SO. "Erk/MAP kinase signaling pathway and neuroendocrine differentiation of non-small-cell lung cancer." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.. 2014 Jan 0; 9(1):50-8.

Huang CK, Lee SO, Luo J, Wang R, Dang Q, Chang C. "A mouse model of liver injury to evaluate paracrine and endocrine effects of bone marrow mesenchymal stem cells." Methods in molecular biology.. 2014 1213:69-79.

Huang CK, Lai KP, Luo J, Tsai MY, Kang HY, Chen Y, Lee SO, Chang C. "Loss of androgen receptor promotes adipogenesis but suppresses osteogenesis in bone marrow stromal cells." Stem cell research. 2013 Sep 0; 11(2):938-50. Epub 2013 Jun 10.

Lin TH, Izumi K, Lee SO, Lin WJ, Yeh S, Chang C. "Anti-androgen receptor ASC-J9 versus anti-androgens MDV3100 (Enzalutamide) or Casodex (Bicalutamide) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and STAT3-CCL2 signaling." Cell death & disease. 2013 Aug 8; 4:e764. Epub 2013 Aug 08.

Lin TH, Lee SO, Niu Y, Xu D, Liang L, Li L, Yeh SD, Fujimoto N, Yeh S, Chang C. "Differential androgen deprivation therapies with anti-androgens casodex/bicalutamide or MDV3100/Enzalutamide versus anti-androgen receptor ASC-J9(R) Lead to promotion versus suppression of prostate cancer metastasis." The Journal of biological chemistry.. 2013 Jul 5; 288(27):19359-69. Epub 2013 May 16.

Chang C, Lee SO, Wang RS, Yeh S, Chang TM. "Androgen receptor (AR) physiological roles in male and female reproductive systems: lessons learned from AR-knockout mice lacking AR in selective cells." Biology of reproduction.. 2013 Jul 0; 89(1):21. Epub 2013 Jul 25.

Yang DR, Ding XF, Luo J, Shan YX, Wang R, Lin SJ, Li G, Huang CK, Zhu J, Chen Y, Lee SO, Chang C. "Increased chemosensitivity via targeting testicular nuclear receptor 4 (TR4)-Oct4-interleukin 1 receptor antagonist (IL1Ra) axis in prostate cancer CD133+ stem/progenitor cells to battle prostate cancer." The Journal of biological chemistry.. 2013 Jun 7; 288(23):16476-83. Epub 2013 Apr 22.

Wang X, Lee SO, Xia S, Jiang Q, Luo J, Li L, Yeh S, Chang C. "Endothelial cells enhance prostate cancer metastasis via IL-6?androgen receptor?TGF-??MMP-9 signals." Molecular cancer therapeutics.. 2013 Jun 0; 12(6):1026-37. Epub 2013 Mar 27.

Huang CK, Tsai MY, Luo J, Kang HY, Lee SO, Chang C. "Suppression of androgen receptor enhances the self-renewal of mesenchymal stem cells through elevated expression of EGFR." Biochimica et biophysica acta.. 2013 May 0; 1833(5):1222-34. Epub 2013 Jan 17.

Huang CK, Lee SO, Lai KP, Ma WL, Lin TH, Tsai MY, Luo J, Chang C. "Targeting androgen receptor in bone marrow mesenchymal stem cells leads to better transplantation therapy efficacy in liver cirrhosis." Hepatology : official journal of the American Association for the Study of Liver Diseases.. 2013 Apr 0; 57(4):1550-63.

Lee SO, Ma Z, Yeh CR, Luo J, Lin TH, Lai KP, Yamashita S, Liang L, Tian J, Li L, Jiang Q, Huang CK, Niu Y, Yeh S, Chang C. "New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells." Journal of molecular cell biology. 2013 Feb 0; 5(1):14-26. Epub 2012 Jul 24.

Li L, Xie H, Liang L, Gao Y, Zhang D, Chen X, Wang X, Chang LS, Wang Y, Yeh S, He D, Chang C. "Increased PrLZ-mediated androgen receptor transactivation promotes prostate cancer growth at castration-resistant stage." Carcinogenesis.. 2013 Feb 0; 34(2):257-67. Epub 2012 Oct 26.

Lai KP, Huang CK, Chang YJ, Chung CY, Yamashita S, Li L, Lee SO, Yeh S, Chang C. "New therapeutic approach to suppress castration-resistant prostate cancer using ASC-J9 via targeting androgen receptor in selective prostate cells." The American journal of pathology.. 2013 Feb 0; 182(2):460-73. Epub 2012 Dec 04.

Chang C, Yeh S, Lee SO, Chang TM. "Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells." Nuclear receptor signaling. 2013 11:e001. Epub 2013 Aug 19.

Tian J, Lee SO, Liang L, Luo J, Huang CK, Li L, Niu Y, Chang C. "Targeting the unique methylation pattern of androgen receptor (AR) promoter in prostate stem/progenitor cells with 5-aza-2'-deoxycytidine (5-AZA) leads to suppressed prostate tumorigenesis." The Journal of biological chemistry.. 2012 Nov 16; 287(47):39954-66. Epub 2012 Sep 25.

Lee SO, Tian J, Huang CK, Ma Z, Lai KP, Hsiao H, Jiang M, Yeh S, Chang C. "Suppressor role of androgen receptor in proliferation of prostate basal epithelial and progenitor cells." The Journal of endocrinology.. 2012 May 0; 213(2):173-82. Epub 2012 Mar 05.

Lee SO, Chun JY, Nadiminty N, Lou W, Feng S, Gao AC. "Interleukin-4 activates androgen receptor through CBP/p300." The Prostate.. 2009 Feb 1; 69(2):126-32.

Lee SO, Pinder E, Chun JY, Lou W, Sun M, Gao AC. "Interleukin-4 stimulates androgen-independent growth in LNCaP human prostate cancer cells." The Prostate.. 2008 Jan 1; 68(1):85-91.

Lee SO, Dutt SS, Nadiminty N, Pinder E, Liao H, Gao AC. "Development of an androgen-deprivation induced and androgen suppressed human prostate cancer cell line." The Prostate.. 2007 Sep 1; 67(12):1293-300.

Lee SO, Chun JY, Nadiminty N, Lou W, Gao AC. "Interleukin-6 undergoes transition from growth inhibitor associated with neuroendocrine differentiation to stimulator accompanied by androgen receptor activation during LNCaP prostate cancer cell progression." The Prostate.. 2007 May 15; 67(7):764-73.

Lee SO, Yeon Chun J, Nadiminty N, Trump DL, Ip C, Dong Y, Gao AC. "Monomethylated selenium inhibits growth of LNCaP human prostate cancer xenograft accompanied by a decrease in the expression of androgen receptor and prostate-specific antigen (PSA)." The Prostate.. 2006 Jul 1; 66(10):1070-5.

Nadiminty N, Lou W, Lee SO, Lin X, Trump DL, Gao AC. "Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation." Proceedings of the National Academy of Sciences of the United States of America.. 2006 May 9; 103(19):7264-9. Epub 2006 May 01.

Chun JY, Nadiminty N, Lee SO, Onate SA, Lou W, Gao AC. "Mechanisms of selenium down-regulation of androgen receptor signaling in prostate cancer." Molecular cancer therapeutics.. 2006 Apr 0; 5(4):913-8.

Nadiminty N, Lou W, Lee SO, Mehraein-Ghomi F, Kirk JS, Conroy JM, Zhang H, Gao AC. "Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2." Clinical cancer research : an official journal of the American Association for Cancer Research.. 2006 Mar 1; 12(5):1420-30.

Tan D, Wu X, Hou M, Lee SO, Lou W, Wang J, Janarthan B, Nallapareddy S, Trump DL, Gao AC. "Interleukin-6 polymorphism is associated with more aggressive prostate cancer." The Journal of urology.. 2005 Aug 0; 174(2):753-6.

Lee SO, Lou W, Nadiminty N, Lin X, Gao AC. "Requirement for NF-(kappa)B in interleukin-4-induced androgen receptor activation in prostate cancer cells." The Prostate.. 2005 Jul 1; 64(2):160-7.

Lee SO, Nadiminty N, Wu XX, Lou W, Dong Y, Ip C, Onate SA, Gao AC. "Selenium disrupts estrogen signaling by altering estrogen receptor expression and ligand binding in human breast cancer cells." Cancer research.. 2005 Apr 15; 65(8):3487-92.

Lee SO, Gao AC. "STAT3 and transactivation of steroid hormone receptors." Vitamins and hormones.. 2005 70:333-57.

Lee SO, Lou W, Qureshi KM, Mehraein-Ghomi F, Trump DL, Gao AC. "RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells." The Prostate.. 2004 Sep 1; 60(4):303-9.

Lee SO, Lou W, Johnson CS, Trump DL, Gao AC. "Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway." The Prostate.. 2004 Aug 1; 60(3):178-86.

Dong Y, Lee SO, Zhang H, Marshall J, Gao AC, Ip C. "Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling." Cancer research.. 2004 Jan 1; 64(1):19-22.

Lee SO, Lou W, Hou M, Onate SA, Gao AC. "Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway." Oncogene.. 2003 Sep 11; 22(39):7981-8.

De Miguel F, Lee SO, Onate SA, Gao AC. "Stat3 enhances transactivation of steroid hormone receptors." Nuclear receptor. 2003 Jun 13; 1(1):3. Epub 2003 Jun 13.

Lee SO, Lou W, Hou M, de Miguel F, Gerber L, Gao AC. "Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells." Clinical cancer research : an official journal of the American Association for Cancer Research.. 2003 Jan 0; 9(1):370-6.

DeMiguel F, Lee SO, Lou W, Xiao X, Pflug BR, Nelson JB, Gao AC. "Stat3 enhances the growth of LNCaP human prostate cancer cells in intact and castrated male nude mice." The Prostate.. 2002 Jul 1; 52(2):123-9.

Ni Z, Lou W, Lee SO, Dhir R, DeMiguel F, Grandis JR, Gao AC. "Selective activation of members of the signal transducers and activators of transcription family in prostate carcinoma." The Journal of urology.. 2002 Apr 0; 167(4):1859-62.

Lee HJ; Kim SW; Lee SO; Park YM; Na DS. "Translocation of Annexin 1 to the nucleus by Epidermal Growth Factor in A549 cells". J Biochem Mol Biol. 1999; 32: 28-32.

Park H; Jang YJ; Kim DH; Lee SO; Na DS. "Transient increase of lipocortin 1 nuclei of the hippocampal pyramidal neurons in rats by immobilization stress". J Biochem Mol Biol. 1998; 31: 117-122.

Kim HW, Choi E, Yoo B, Choi JR, Park YM, Lee SO, Moon HB, Na DS. "Lipocortin 1 binding sites on human T-cells: the population of cells with the binding sites is larger in CD8+ T-lymphocytes than in CD4+ T-lymphocytes." Biochemistry and molecular biology international.. 1996 Dec 0; 40(6):1167-73.

Huh KR; Cho EH; Lee SO; Na DS. "High level expression of human lipocortin (annexin) 1 in Escherichia coli". Biotechnology Letters. 1996; 18: 163-168.

Kim GY; Lee HB; Lee SO; Rhee HJ; Na DS. "Chaperone like function of lipocortin-1 in human glomerulonephritis". Nephrology. 1996; 2: 235-240.

Kim SB, Yang WS, Lee OS, Lee KP, Park JS, Na DS. "Lipocortin-1 inhibits proliferation of cultured human mesangial cells." Nephron.. 1996 74(1):39-44.

Lee SO, Poretz RD. "Hybrid myeloma cells which secrete heterodimeric IgG: a model to study the N-linked glycan." Immunology and cell biology.. 1991 Jun 0; 69 ( Pt 3):151-7.

Lee SO, Connolly JM, Ramirez-Soto D, Poretz RD. "The polypeptide of immunoglobulin G influences its galactosylation in vivo." The Journal of biological chemistry.. 1990 Apr 5; 265(10):5833-9.