Soo Ok Lee, Ph.D.

Soo Ok Lee, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Office: (585) 276-5242

Journal Articles

Showing all 62 journal articles available.

2016 Dec
Wen S, Niu Y, Lee SO, Yeh S, Shang Z, Gao H, Li Y, Chou F, Chang C. "Targeting fatty acid synthase with ASC-J9 suppresses proliferation and invasion of prostate cancer cells." Molecular carcinogenesis. 2016 Dec; 55(12):2278-2290. Epub 2016 Feb 19.
2016 Jun
Zhang F, Duan S, Tsai Y, Keng P, Chen Y, Lee SO, Chen Y. "Cisplatin treatment increases stemness through upregulation of hypoxia-inducible factors by interleukin-6 in non-small cell lung cancer." Cancer science. 2016 Jun; 107(6):746-54. Epub 2016 May 03.
2016 Apr
Huang CK, Lee SO, Chang E, Pang H, Chang C. "Androgen receptor (AR) in cardiovascular diseases." The Journal of endocrinology. 2016 Apr; 229(1):R1-R16. Epub 2016 Jan 14.
2016 Feb 9
Lee SO, Yang X, Duan S, Tsai Y, Strojny LR, Keng P, Chen Y. "IL-6 promotes growth and epithelial-mesenchymal transition of CD133+ cells of non-small cell lung cancer." Oncotarget. 2016 Feb 9; 7(6):6626-38.
Yang L; Zhang F; Wang X; Tsai Y; Chuang KH; Keng PC; Lee SO; Chen Y. "A FASN-TGF-?1-FASN regulatory loop contributes to high EMT/metastatic potential of cisplatin-resistant non-small cell lung cancer". Oncotarget. 2016; 7(34): 55543-55554.
2015 Nov 14
Chen Y, Zhang F, Tsai Y, Yang X, Yang L, Duan S, Wang X, Keng P, Lee SO. "IL-6 signaling promotes DNA repair and prevents apoptosis in CD133+ stem-like cells of lung cancer after radiation." Radiation oncology. 2015 Nov 14; 10:227. Epub 2015 Nov 14.
2015 Oct
Huang CK, Luo J, Lai KP, Wang R, Pang H, Chang E, Yan C, Sparks J, Lee SO, Cho J, Chang C. "Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1? and transforming growth factor-?1 expression." Hypertension. 2015 Oct; 66(4):881-91.
2015 Sep 29
Duan S, Tsai Y, Keng P, Chen Y, Lee SO, Chen Y. "IL-6 signaling contributes to cisplatin resistance in non-small cell lung cancer via the up-regulation of anti-apoptotic and DNA repair associated molecules." Oncotarget. 2015 Sep 29; 6(29):27651-60.
2015 Sep 29
Luo J, Lee SO, Cui Y, Yang R, Li L, Chang C. "Infiltrating bone marrow mesenchymal stem cells (BM-MSCs) increase prostate cancer cell invasion via altering the CCL5/HIF2?/androgen receptor signals." Oncotarget. 2015 Sep 29; 6(29):27555-65.
2015 Feb 15
Ding X, Yang DR, Lee SO, Chen YL, Xia LQ, Lin SJ, Yu SC, Niu YJ, Li G, Chang C. "TR4 nuclear receptor promotes prostate cancer metastasis via upregulation of CCL2/CCR2 signaling." International journal of cancer. 2015 Feb 15; 136(4):955-64. Epub 2014 Jul 14.
2014 Sep
Huang CK, Luo J, Lee SO, Chang C. "Concise review: androgen receptor differential roles in stem/progenitor cells including prostate, embryonic, stromal, and hematopoietic lineages." Stem cells. 2014 Sep; 32(9):2299-308.
2014 Aug
Liang L, Li L, Tian J, Lee SO, Dang Q, Huang CK, Yeh S, Erturk E, Bushinsky D, Chang LS, He D, Chang C. "Androgen receptor enhances kidney stone-CaOx crystal formation via modulation of oxalate biosynthesis & oxidative stress." Molecular endocrinology. 2014 Aug; 28(8):1291-303. Epub 2014 Jun 23.
2014 Jun 19
Chang C, Lee SO, Yeh S, Chang TM. "Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver." Oncogene. 2014 Jun 19; 33(25):3225-34. Epub 2013 Jul 22.
2014 Jun
Lin SJ, Lee SO, Lee YF, Miyamoto H, Yang DR, Li G, Chang C. "TR4 nuclear receptor functions as a tumor suppressor for prostate tumorigenesis via modulation of DNA damage/repair system." Carcinogenesis. 2014 Jun; 35(6):1399-406. Epub 2014 Feb 28.
2014 Jun
Huang CK, Pang H, Wang L, Niu Y, Luo J, Chang E, Sparks JD, Lee SO, Chang C. "New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis." Hypertension. 2014 Jun; 63(6):1345-53. Epub 2014 Mar 31.
2014 May 22
Luo J, Ok Lee S, Liang L, Huang CK, Li L, Wen S, Chang C. "Infiltrating bone marrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling." Oncogene. 2014 May 22; 33(21):2768-78. Epub 2013 Jun 24.
2014 Feb
Wen S, Niu Y, Lee SO, Chang C. "Androgen receptor (AR) positive vs negative roles in prostate cancer cell deaths including apoptosis, anoikis, entosis, necrosis and autophagic cell death." Cancer treatment reviews. 2014 Feb; 40(1):31-40. Epub 2013 Aug 07.
2014 Jan
Soh SF, Huang CK, Lee SO, Xu D, Yeh S, Li J, Yong EL, Gong Y, Chang C. "Determination of androgen receptor degradation enhancer ASC-J9(®) in mouse sera and organs with liquid chromatography tandem mass spectrometry." Journal of pharmaceutical and biomedical analysis. 2014 Jan; 88:117-22. Epub 2013 Aug 27.
2014 Jan
Chen Y, Nowak I, Huang J, Keng PC, Sun H, Xu H, Wei G, Lee SO. "Erk/MAP kinase signaling pathway and neuroendocrine differentiation of non-small-cell lung cancer." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2014 Jan; 9(1):50-8.
Huang CK, Lee SO, Luo J, Wang R, Dang Q, Chang C. "A mouse model of liver injury to evaluate paracrine and endocrine effects of bone marrow mesenchymal stem cells." Methods in molecular biology. 2014 1213:69-79.
2013 Sep
Huang CK, Lai KP, Luo J, Tsai MY, Kang HY, Chen Y, Lee SO, Chang C. "Loss of androgen receptor promotes adipogenesis but suppresses osteogenesis in bone marrow stromal cells." Stem cell research. 2013 Sep; 11(2):938-50. Epub 2013 Jun 10.
2013 Aug 8
Lin TH, Izumi K, Lee SO, Lin WJ, Yeh S, Chang C. "Anti-androgen receptor ASC-J9 versus anti-androgens MDV3100 (Enzalutamide) or Casodex (Bicalutamide) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and STAT3-CCL2 signaling." Cell death & disease. 2013 Aug 8; 4:e764. Epub 2013 Aug 08.
2013 Jul 5
Lin TH, Lee SO, Niu Y, Xu D, Liang L, Li L, Yeh SD, Fujimoto N, Yeh S, Chang C. "Differential androgen deprivation therapies with anti-androgens casodex/bicalutamide or MDV3100/Enzalutamide versus anti-androgen receptor ASC-J9(R) Lead to promotion versus suppression of prostate cancer metastasis." The Journal of biological chemistry. 2013 Jul 5; 288(27):19359-69. Epub 2013 May 16.
2013 Jul
Chang C, Lee SO, Wang RS, Yeh S, Chang TM. "Androgen receptor (AR) physiological roles in male and female reproductive systems: lessons learned from AR-knockout mice lacking AR in selective cells." Biology of reproduction. 2013 Jul; 89(1):21. Epub 2013 Jul 25.
2013 Jun 7
Yang DR, Ding XF, Luo J, Shan YX, Wang R, Lin SJ, Li G, Huang CK, Zhu J, Chen Y, Lee SO, Chang C. "Increased chemosensitivity via targeting testicular nuclear receptor 4 (TR4)-Oct4-interleukin 1 receptor antagonist (IL1Ra) axis in prostate cancer CD133+ stem/progenitor cells to battle prostate cancer." The Journal of biological chemistry. 2013 Jun 7; 288(23):16476-83. Epub 2013 Apr 22.
2013 Jun
Wang X, Lee SO, Xia S, Jiang Q, Luo J, Li L, Yeh S, Chang C. "Endothelial cells enhance prostate cancer metastasis via IL-6?androgen receptor?TGF-??MMP-9 signals." Molecular cancer therapeutics. 2013 Jun; 12(6):1026-37. Epub 2013 Mar 27.
2013 May
Huang CK, Tsai MY, Luo J, Kang HY, Lee SO, Chang C. "Suppression of androgen receptor enhances the self-renewal of mesenchymal stem cells through elevated expression of EGFR." Biochimica et biophysica acta. 2013 May; 1833(5):1222-34. Epub 2013 Jan 17.
2013 Apr
Huang CK, Lee SO, Lai KP, Ma WL, Lin TH, Tsai MY, Luo J, Chang C. "Targeting androgen receptor in bone marrow mesenchymal stem cells leads to better transplantation therapy efficacy in liver cirrhosis." Hepatology : official journal of the American Association for the Study of Liver Diseases. 2013 Apr; 57(4):1550-63.
2013 Feb
Lee SO, Ma Z, Yeh CR, Luo J, Lin TH, Lai KP, Yamashita S, Liang L, Tian J, Li L, Jiang Q, Huang CK, Niu Y, Yeh S, Chang C. "New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells." Journal of molecular cell biology. 2013 Feb; 5(1):14-26. Epub 2012 Jul 24.
2013 Feb
Li L, Xie H, Liang L, Gao Y, Zhang D, Chen X, Wang X, Chang LS, Wang Y, Yeh S, He D, Chang C. "Increased PrLZ-mediated androgen receptor transactivation promotes prostate cancer growth at castration-resistant stage." Carcinogenesis. 2013 Feb; 34(2):257-67. Epub 2012 Oct 26.
2013 Feb
Lai KP, Huang CK, Chang YJ, Chung CY, Yamashita S, Li L, Lee SO, Yeh S, Chang C. "New therapeutic approach to suppress castration-resistant prostate cancer using ASC-J9 via targeting androgen receptor in selective prostate cells." The American journal of pathology. 2013 Feb; 182(2):460-73. Epub 2012 Dec 04.
Chang C, Yeh S, Lee SO, Chang TM. "Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells." Nuclear receptor signaling. 2013 11:e001. Epub 2013 Aug 19.
2012 Nov 16
Tian J, Lee SO, Liang L, Luo J, Huang CK, Li L, Niu Y, Chang C. "Targeting the unique methylation pattern of androgen receptor (AR) promoter in prostate stem/progenitor cells with 5-aza-2'-deoxycytidine (5-AZA) leads to suppressed prostate tumorigenesis." The Journal of biological chemistry. 2012 Nov 16; 287(47):39954-66. Epub 2012 Sep 25.
2012 May
Lee SO, Tian J, Huang CK, Ma Z, Lai KP, Hsiao H, Jiang M, Yeh S, Chang C. "Suppressor role of androgen receptor in proliferation of prostate basal epithelial and progenitor cells." The Journal of endocrinology. 2012 May; 213(2):173-82. Epub 2012 Mar 05.
2009 Feb 1
Lee SO, Chun JY, Nadiminty N, Lou W, Feng S, Gao AC. "Interleukin-4 activates androgen receptor through CBP/p300." The Prostate. 2009 Feb 1; 69(2):126-32.
2008 Jan 1
Lee SO, Pinder E, Chun JY, Lou W, Sun M, Gao AC. "Interleukin-4 stimulates androgen-independent growth in LNCaP human prostate cancer cells." The Prostate. 2008 Jan 1; 68(1):85-91.
2007 Sep 1
Lee SO, Dutt SS, Nadiminty N, Pinder E, Liao H, Gao AC. "Development of an androgen-deprivation induced and androgen suppressed human prostate cancer cell line." The Prostate. 2007 Sep 1; 67(12):1293-300.
2007 May 15
Lee SO, Chun JY, Nadiminty N, Lou W, Gao AC. "Interleukin-6 undergoes transition from growth inhibitor associated with neuroendocrine differentiation to stimulator accompanied by androgen receptor activation during LNCaP prostate cancer cell progression." The Prostate. 2007 May 15; 67(7):764-73.
2006 Jul 1
Lee SO, Yeon Chun J, Nadiminty N, Trump DL, Ip C, Dong Y, Gao AC. "Monomethylated selenium inhibits growth of LNCaP human prostate cancer xenograft accompanied by a decrease in the expression of androgen receptor and prostate-specific antigen (PSA)." The Prostate. 2006 Jul 1; 66(10):1070-5.
2006 May 9
Nadiminty N, Lou W, Lee SO, Lin X, Trump DL, Gao AC. "Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation." Proceedings of the National Academy of Sciences of the United States of America. 2006 May 9; 103(19):7264-9. Epub 2006 May 01.
2006 Apr
Chun JY, Nadiminty N, Lee SO, Onate SA, Lou W, Gao AC. "Mechanisms of selenium down-regulation of androgen receptor signaling in prostate cancer." Molecular cancer therapeutics. 2006 Apr; 5(4):913-8.
2006 Mar 1
Nadiminty N, Lou W, Lee SO, Mehraein-Ghomi F, Kirk JS, Conroy JM, Zhang H, Gao AC. "Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2." Clinical cancer research : an official journal of the American Association for Cancer Research. 2006 Mar 1; 12(5):1420-30.
2005 Aug
Tan D, Wu X, Hou M, Lee SO, Lou W, Wang J, Janarthan B, Nallapareddy S, Trump DL, Gao AC. "Interleukin-6 polymorphism is associated with more aggressive prostate cancer." The Journal of urology. 2005 Aug; 174(2):753-6.
2005 Jul 1
Lee SO, Lou W, Nadiminty N, Lin X, Gao AC. "Requirement for NF-(kappa)B in interleukin-4-induced androgen receptor activation in prostate cancer cells." The Prostate. 2005 Jul 1; 64(2):160-7.
2005 Apr 15
Lee SO, Nadiminty N, Wu XX, Lou W, Dong Y, Ip C, Onate SA, Gao AC. "Selenium disrupts estrogen signaling by altering estrogen receptor expression and ligand binding in human breast cancer cells." Cancer research. 2005 Apr 15; 65(8):3487-92.
Lee SO, Gao AC. "STAT3 and transactivation of steroid hormone receptors." Vitamins and hormones. 2005 70:333-57.
2004 Sep 1
Lee SO, Lou W, Qureshi KM, Mehraein-Ghomi F, Trump DL, Gao AC. "RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells." The Prostate. 2004 Sep 1; 60(4):303-9.
2004 Aug 1
Lee SO, Lou W, Johnson CS, Trump DL, Gao AC. "Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway." The Prostate. 2004 Aug 1; 60(3):178-86.
2004 Jan 1
Dong Y, Lee SO, Zhang H, Marshall J, Gao AC, Ip C. "Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling." Cancer research. 2004 Jan 1; 64(1):19-22.
2003 Sep 11
Lee SO, Lou W, Hou M, Onate SA, Gao AC. "Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway." Oncogene. 2003 Sep 11; 22(39):7981-8.
2003 Jun 13
De Miguel F, Lee SO, Onate SA, Gao AC. "Stat3 enhances transactivation of steroid hormone receptors." Nuclear receptor. 2003 Jun 13; 1(1):3. Epub 2003 Jun 13.
2003 Jan
Lee SO, Lou W, Hou M, de Miguel F, Gerber L, Gao AC. "Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells." Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 Jan; 9(1):370-6.
2002 Jul 1
DeMiguel F, Lee SO, Lou W, Xiao X, Pflug BR, Nelson JB, Gao AC. "Stat3 enhances the growth of LNCaP human prostate cancer cells in intact and castrated male nude mice." The Prostate. 2002 Jul 1; 52(2):123-9.
2002 Apr
Ni Z, Lou W, Lee SO, Dhir R, DeMiguel F, Grandis JR, Gao AC. "Selective activation of members of the signal transducers and activators of transcription family in prostate carcinoma." The Journal of urology. 2002 Apr; 167(4):1859-62.
Lee HJ; Kim SW; Lee SO; Park YM; Na DS. "Translocation of Annexin 1 to the nucleus by Epidermal Growth Factor in A549 cells". J Biochem Mol Biol. 1999; 32: 28-32.
Park H; Jang YJ; Kim DH; Lee SO; Na DS. "Transient increase of lipocortin 1 nuclei of the hippocampal pyramidal neurons in rats by immobilization stress". J Biochem Mol Biol. 1998; 31: 117-122.
1996 Dec
Kim HW, Choi E, Yoo B, Choi JR, Park YM, Lee SO, Moon HB, Na DS. "Lipocortin 1 binding sites on human T-cells: the population of cells with the binding sites is larger in CD8+ T-lymphocytes than in CD4+ T-lymphocytes." Biochemistry and molecular biology international. 1996 Dec; 40(6):1167-73.
Huh KR; Cho EH; Lee SO; Na DS. "High level expression of human lipocortin (annexin) 1 in Escherichia coli". Biotechnology Letters. 1996; 18: 163-168.
Kim GY; Lee HB; Lee SO; Rhee HJ; Na DS. "Chaperone like function of lipocortin-1 in human glomerulonephritis". Nephrology. 1996; 2: 235-240.
Kim SB, Yang WS, Lee OS, Lee KP, Park JS, Na DS. "Lipocortin-1 inhibits proliferation of cultured human mesangial cells." Nephron. 1996 74(1):39-44.
1991 Jun
Lee SO, Poretz RD. "Hybrid myeloma cells which secrete heterodimeric IgG: a model to study the N-linked glycan." Immunology and cell biology. 1991 Jun; 69 ( Pt 3):151-7.
1990 Apr 5
Lee SO, Connolly JM, Ramirez-Soto D, Poretz RD. "The polypeptide of immunoglobulin G influences its galactosylation in vivo." The Journal of biological chemistry. 1990 Apr 5; 265(10):5833-9.