Skip to main content
Explore URMC

URMC Logo

menu

Dorota Lucja Piekna-Przybylska, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Faculty Appointments

Biography

Research

HIV Replication and Latency: The Role of RNA and DNA G-quadruplexes.
G-quadruplexes are guanine rich nucleic acid structures capable of forming a four-stranded structure. DNA G-quadruplexes have been identified in telomeric DNA as well as more recently in mammalian chromosomal DNA - and are considered attractive targets in anti-cancer drug development studies.
We have recently shown that guanine-rich sequences in the HIV-1 genome can adopt G-quadruplex structures in both viral RNA and DNA. Viral RNA G-quadruplexes support genome dimerization and may facilitate viral recombination, which contributes to viral diversity. We have also identified G-quadruplexes in the promoter region of HIV-1 proviral DNA (Sp1 binding sites). This suggests that these structures may also contribute to the regulation of viral gene expression (i.e., regulation of latency and reactivation). Our current research focuses on understanding the role of G-quadruplexes in HIV-1 DNA, and determining whether these structures may represent a new target for antiviral therapies.

Credentials

Education

1997
MSc | Poland-Adam Mickiewicz Univ
Biochemistry

2002
PhD | Poland-Adam Mickiewicz Univ
Molecular Biology

Post-doctoral Training & Residency

2008 - 2011
Postdoctoral Research Associate - Laboratory of Dr. Robert Bambara. University of Rochester, Rochester, NY, United States

01/2003 - 06/2008
Postdoctoral Research Associate - Laboratory of Dr. Maurille (Skip) Fournier. University of Massachusetts, Amherst, MA, United States

Publications

Journal Articles

9/9/2018
Piekna-Przybylska D, Maggirwar SB. "CD4+ memory T cells infected with latent HIV-1 are susceptible to drugs targeting telomeres." Cell cycle.. 2018 Sep 9; :1-17. Epub 2018 Sep 09.

1/2018
Falsetta ML, Foster DC, Woeller CF, Pollock SJ, Bonham AD, Piekna-Przybylska D, Maggirwar SB, Haidaris CG, Phipps RP. "Toll-Like Receptor Signaling Contributes to Proinflammatory Mediator Production in Localized Provoked Vulvodynia." Journal of lower genital tract disease.. 2018 Jan 0; 22(1):52-57.

8/29/2017
Singh VB, Singh MV, Piekna-Przybylska D, Gorantla S, Poluektova LY, Maggirwar SB. "Sonic Hedgehog mimetic prevents leukocyte infiltration into the CNS during acute HIV infection." Scientific reports.. 2017 Aug 29; 7(1):9578. Epub 2017 Aug 29.

Books & Chapters

2013
Chapter Title: Proviral DNA Synthesis in HIV: Background
Book Title: Human Immunodeficiency Virus Reverse Transcriptase. A Bench-to-Bedside Success.
Author List: Piekna-Przybylska D, Bambara RA.
Edited By: LeGrice and M. Gotte
Published By: Springer2013 in New York

VIEW ALL PUBLICATIONS