Skip to main content
Explore URMC
menu

Dorota Lucja Piekna-Przybylska, Ph.D.

Contact Information

Biography

Research

HIV Replication and Latency: DNA damage response in HIV infected cells

Relationships between viruses and DNA damage response (DDR) in host are well described and show that viruses modulate cell metabolism and interact with cellular mechanisms to activate or deactivate different pathways in DNA damage repair. Cells with affected DNA repair pathway were shown to be more vulnerable to targeting DDR causing increases in DNA damage to the level that triggers apoptosis. HIV-1 influences DDR during active infection, and my studies showed for the first time that latently infected cells exhibit deficiencies in DDR and telomere maintenance (TM), indicating that HIV-1 latency has impact on a host ability to efficiently respond to DNA damage. My research interest is focused on investigating latency and virus-mediated alterations in DDR and TM in different HIV reservoirs, with major focus on memory CD4+ T cells and HIV reservoirs in CNS.

Credentials

Education

2003
PhD | Poland-Adam Mickiewicz Univ
Molecular Biology

Post-doctoral Training & Residency

2008 - 2011
Postdoctoral Research Associate - Laboratory of Dr. Robert Bambara. University of Rochester, Rochester, NY, United States

2003 - 2008
Postdoctoral Research Associate - Laboratory of Dr. Maurille (Skip) Fournier. University of Massachusetts, Amherst, MA, United States

Awards

2017 - 2020
NIH Exploratory/Developmental Research Grant Award (R21)
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

2014 - 2015
Center for AIDS Research (CFAR) Developmental Pilot Project Award
Sponsor: University of Rochester Medical Center

2012 - 2013
Center for AIDS Research (CFAR) Developmental Pilot Project Award
Sponsor: University of Rochester Medical Center

VIEW ALL expand_more

Publications

Journal Articles

8/17/2020
Piekna-Przybylska D, Bambara RA, Maggirwar SB, Dewhurst S. "G-quadruplex ligands targeting telomeres do not inhibit HIV promoter activity and cooperate with latency reversing agents in killing latently infected cells." Cell cycle.. 2020 Aug 17; :1-16. Epub 2020 Aug 17.

2020
Piekna-Przybylska D, Bambara RA, Maggirwar SB, Dewhurst D. "G-quadruplex ligands targeting telomeres do not inhibit HIV promoter activity and cooperate with latency reversing agents in killing latently infected cells." Cell Cycle. 2020; .

2019
Piekna-Przybylska D. "Reporter Assays for BER Pathway." Methods in molecular biology.. 2019 1999:145-160.

Books & Chapters

2019
Chapter Title: Reporter Assays for BER Pathway.
Book Title: DNA Repair. Methods Mol Biol
Author List: Dorota Piekna-Przybylska
Edited By: Balakrishnan L., Stewart J.
Published By: Humana, New York, NY 2019

2013
Chapter Title: Proviral DNA Synthesis in HIV: Background
Book Title: Human Immunodeficiency Virus Reverse Transcriptase. A Bench-to-Bedside Success.
Author List: Piekna-Przybylska D, Bambara RA.
Edited By: LeGrice and M. Gotte
Published By: Springer 2013 in New York

VIEW ALL PUBLICATIONS