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Dorota Lucja Piekna-Przybylska, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Biography

Research

HIV Replication and Latency: The Role of RNA and DNA G-quadruplexes.
G-quadruplexes are guanine rich nucleic acid structures capable of forming a four-stranded structure. DNA G-quadruplexes have been identified in telomeric DNA as well as more recently in mammalian chromosomal DNA - and are considered attractive targets in anti-cancer drug development studies.
We have recently shown that guanine-rich sequences in the HIV-1 genome can adopt G-quadruplex structures in both viral RNA and DNA. Viral RNA G-quadruplexes support genome dimerization and may facilitate viral recombination, which contributes to viral diversity. We have also identified G-quadruplexes in the promoter region of HIV-1 proviral DNA (Sp1 binding sites). This suggests that these structures may also contribute to the regulation of viral gene expression (i.e., regulation of latency and reactivation). Our current research focuses on understanding the role of G-quadruplexes in HIV-1 DNA, and determining whether these structures may represent a new target for antiviral therapies.

Credentials

Faculty Appointments

Education

1997
MSc | Poland-Adam Mickiewicz Univ
Biochemistry

2002
PhD | Poland-Adam Mickiewicz Univ
Molecular Biology

Publications

Journal Articles

4/7/2017
Piekna-Przybylska D, Sharma G, Maggirwar SB, Bambara RA. "Deficiency in DNA damage response, a new characteristic of cells infected with latent HIV-1." Cell cycle.. 2017 Apr 7; :1-11. Epub 2017 Apr 07.

6/2/2016
Piekna-Przybylska D, Bambara RA, Balakrishnan L. "Acetylation regulates DNA repair mechanisms in human cells." Cell cycle.. 2016 Jun 2; 15(11):1506-17. Epub 2016 Apr 22.

4/29/2014
Piekna-Przybylska D, Sullivan MA, Sharma G, Bambara RA. "U3 region in the HIV-1 genome adopts a G-quadruplex structure in its RNA and DNA sequence." Biochemistry.. 2014 Apr 29; 53(16):2581-93. Epub 2014 Apr 15.

Books & Chapters

2013
Chapter Title: Proviral DNA Synthesis in HIV: Background
Book Title: Human Immunodeficiency Virus Reverse Transcriptase. A Bench-to-Bedside Success.
Author List: Piekna-Przybylska D, Bambara RA.
Edited By: LeGrice and M. Gotte
Published By: Springer2013 in New York

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