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Dorota Lucja Piekna-Przybylska, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Faculty Appointments



HIV Replication and Latency: The Role of RNA and DNA G-quadruplexes.
G-quadruplexes are guanine rich nucleic acid structures capable of forming a four-stranded structure. DNA G-quadruplexes have been identified in telomeric DNA as well as more recently in mammalian chromosomal DNA - and are considered attractive targets in anti-cancer drug development studies.
We have recently shown that guanine-rich sequences in the HIV-1 genome can adopt G-quadruplex structures in both viral RNA and DNA. Viral RNA G-quadruplexes support genome dimerization and may facilitate viral recombination, which contributes to viral diversity. We have also identified G-quadruplexes in the promoter region of HIV-1 proviral DNA (Sp1 binding sites). This suggests that these structures may also contribute to the regulation of viral gene expression (i.e., regulation of latency and reactivation). Our current research focuses on understanding the role of G-quadruplexes in HIV-1 DNA, and determining whether these structures may represent a new target for antiviral therapies.



MSc | Poland-Adam Mickiewicz Univ

PhD | Poland-Adam Mickiewicz Univ
Molecular Biology

Post-doctoral Training & Residency

2008 - 2011
Postdoctoral Research Associate - Laboratory of Dr. Robert Bambara. University of Rochester, Rochester, NY, United States

01/2003 - 06/2008
Postdoctoral Research Associate - Laboratory of Dr. Maurille (Skip) Fournier. University of Massachusetts, Amherst, MA, United States


Journal Articles

Piekna-Przybylska D, Nagumotu K, Reid DM, Maggirwar SB. "HIV-1 infection renders brain vascular pericytes susceptible to the extracellular glutamate." Journal of neurovirology.. 2018 Nov 6; Epub 2018 Nov 06.

Falsetta ML, Foster DC, Woeller CF, Pollock SJ, Bonham AD, Piekna-Przybylska D, Maggirwar SB, Haidaris CG, Phipps RP. "Toll-Like Receptor Signaling Contributes to Proinflammatory Mediator Production in Localized Provoked Vulvodynia." Journal of lower genital tract disease.. 2018 Jan 0; 22(1):52-57.

Piekna-Przybylska D, Maggirwar SB. "CD4+ memory T cells infected with latent HIV-1 are susceptible to drugs targeting telomeres." Cell cycle.. 2018 17(17):2187-2203. Epub 2018 Sep 20.

Books & Chapters

Chapter Title: Proviral DNA Synthesis in HIV: Background
Book Title: Human Immunodeficiency Virus Reverse Transcriptase. A Bench-to-Bedside Success.
Author List: Piekna-Przybylska D, Bambara RA.
Edited By: LeGrice and M. Gotte
Published By: Springer 2013 in New York