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Dorota Lucja Piekna-Przybylska, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Faculty Appointments

Biography

Research

HIV Replication and Latency: DNA damage response in HIV infected cells

Relationships between viruses and DNA damage response (DDR) in host are well described and show that viruses modulate cell metabolism and interact with cellular mechanisms to activate or deactivate different pathways in DNA damage repair. Cells with affected DNA repair pathway were shown to be more vulnerable to targeting DDR causing increases in DNA damage to the level that triggers apoptosis. HIV-1 influences DDR during active infection, and my studies showed for the first time that latently infected cells exhibit deficiencies in DDR and telomere maintenance (TM), indicating that HIV-1 latency has impact on a host ability to efficiently respond to DNA damage. My research interest is focused on investigating latency and virus-mediated alterations in DDR and TM in different HIV reservoirs, with major focus on memory CD4+ T cells and HIV reservoirs in CNS.

Credentials

Education

2003
PhD | Poland-Adam Mickiewicz Univ
Molecular Biology

Post-doctoral Training & Residency

2008 - 2011
Postdoctoral Research Associate - Laboratory of Dr. Robert Bambara. University of Rochester, Rochester, NY, United States

2003 - 2008
Postdoctoral Research Associate - Laboratory of Dr. Maurille (Skip) Fournier. University of Massachusetts, Amherst, MA, United States

Publications

Journal Articles

11/6/2018
Piekna-Przybylska D, Nagumotu K, Reid DM, Maggirwar SB. "HIV-1 infection renders brain vascular pericytes susceptible to the extracellular glutamate." Journal of neurovirology.. 2018 Nov 6; Epub 2018 Nov 06.

1/2018
Falsetta ML, Foster DC, Woeller CF, Pollock SJ, Bonham AD, Piekna-Przybylska D, Maggirwar SB, Haidaris CG, Phipps RP. "Toll-Like Receptor Signaling Contributes to Proinflammatory Mediator Production in Localized Provoked Vulvodynia." Journal of lower genital tract disease.. 2018 Jan 0; 22(1):52-57.

2018
Piekna-Przybylska D, Maggirwar SB. "CD4+ memory T cells infected with latent HIV-1 are susceptible to drugs targeting telomeres." Cell cycle.. 2018 17(17):2187-2203. Epub 2018 Sep 20.

Books & Chapters

2019
Chapter Title: Reporter Assays for BER Pathway.
Book Title: DNA Repair. Methods Mol Biol
Author List: Dorota Piekna-Przybylska
Edited By: Balakrishnan L., Stewart J.
Published By: Humana, New York, NY 2019

2013
Chapter Title: Proviral DNA Synthesis in HIV: Background
Book Title: Human Immunodeficiency Virus Reverse Transcriptase. A Bench-to-Bedside Success.
Author List: Piekna-Przybylska D, Bambara RA.
Edited By: LeGrice and M. Gotte
Published By: Springer 2013 in New York

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