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Zhongren Zhou, B.Med., Ph.D.

Pathology

Contact Information

Phone Numbers

Administrative: (585) 275-1959

Fax: (585) 276-2832

Office: (585) 276-4718

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentNot Accepting New Patients

Biography

Dr. Zhongren (David) Zhou is a surgical and cytopathologist with interests in gastrointestinal pathology, in particular esophageal pathology. He performs translational research using tissue microarrays and banked frozen tissue specimens to study the gene amplification, overexpression and molecular changes in esophageal cancer. The goal of these studies is to discover new biomarkers for early diagnosis and/or for screening of patients at high risk for esophageal cancer development.

Research

I am an associate professor in University of Rochester with subspecialized GI and cytology practice. I am very interested in translational research on the esophageal carcinoma and precancerous lesions. I am developing a new screening test for Barrett's esophagous and other precancerous lesions.This new screening method will combine cytology, immunohistochemistry and next generation sequencing to find patients with Barrett's esophagus and predict the high risk patients for esophageal adenocarcinoma. In addition, I am involved in studying a new diagnosis method for the recurrent esophageal adenocarcinoma with blood sample and next generation sequencing. I also join the TCGA GI committee in National Cancer Institute to detect the genetic mutation related with esophageal carcinoma and gastric adenocarcinoma and American Society of Cytopathology, Research and Current Concepts Committee (review abstracts and presentation for Awards).

Credentials

Faculty Appointments

Specialties

  • Anatomic Pathology and Clinical Pathology - American Board of Pathology
  • Cytopathology - American Board of Pathology

Education

1986
MD | North China University of Science and Technology (formerly School of Medicine, Hebei United University)
Medicine

1989
MS | Capital University of Medical Science
Anatomy

1993
PhD | Shanghai Medical College; Fundan University
Neurobiology

Post-doctoral Training & Residency

07/01/2002 - 06/30/2003
Residency in Pathology-Anatomic and Clinical at North Shore University Hospital

07/01/2003 - 06/30/2006
Residency in Pathology-Anatomic and Clinical at Boston University Medical Center - University Hospital

07/01/2006 - 06/30/2007
Fellowship in Pathology-Anatomic and Clinical: Cytopathology at Baylor College of Medicine

07/01/2007 - 06/30/2008
Fellowship in Internal Medicine: Oncology at M.D. Anderson Cancer Cnter

02/01/1994 - 07/31/1998
Fellowship in at Harvard

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Awards

2011
CAPA Award for the best research abstract

1992
Annual Science Festival Award for Outstanding Research Work
Sponsor: Shanghai Medical University

1992
Guang-Hua Award for Outstanding Graduate Student
Sponsor: Shanghai Medical University

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Publications

Journal Articles

2017
Cancer Genome Atlas Research Network; Analysis Working Group: Asan University; BC Cancer Agency; Brigham and Women's Hospital; Broad Institute; Brown University; Case Western Reserve University; Dana-Farber Cancer Institute; Duke University; Greater Poland Cancer Centre; Harvard Medical School; Institute for Systems Biology; KU Leuven; Mayo Clinic; Memorial Sloan Kettering Cancer Center; National Cancer Institute; Nationwide Children's Hospital; Stanford University; University of Alabama; University of Mich. "Integrated genomic characterization of oesophageal carcinoma." Nature. 2017; 541(7636): 169-175.

11/2016
Choy B, LaLonde A, Que J, Wu T, Zhou Z. "MCM4 and MCM7, potential novel proliferation markers, significantly correlated with Ki-67, Bmi1, and cyclin E expression in esophageal adenocarcinoma, squamous cell carcinoma, and precancerous lesions." Human pathology.. 2016 Nov 0; 57:126-135. Epub 2016 Jul 29.

2016
Ghatak S, Reveiller M, Toia L, Ivanov AI, Zhou Z, Redmond EM, Godfrey TE, Peters JH. "Low pH Cause Dilation of Intercellular Spaces in In Vitro Stratified Primary Esophageal Cells, Possibly by Modulating Wnt Signaling". J Gastrointest Surg. 2016; 20(3): 500-9.

Books & Chapters

2013
Chapter Title: HER2 Amplification or Overexpression in Upper GI Tract and Breast Cancer with Clinical Diagnosis and Treatment
Book Title: Oncogene and Cancer--From Bench to Clinic
Author List: Zhou Z, and Hicks DG
Edited By: Yahwardiah Siregar
Published By: InTech2013

2008
Chapter Title: Therapeutic Concentrations of Local Anaesthetics Unveil the Potential Role of Sodium Channels in Neuropathic Pain
Book Title: Sodium Channels and Neuronal Hyperexcitability
Author List: Strichartz, GR, Zhou Z, Sinnott C, and Khodorova A.
Published By: Novartis Foundation2008

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