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Luis Martinez-Sobrido, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-4733

Research Labs

Dr. Luis Martinez-Sobrido research interest focuses on the molecular biology and in the evasion of the innate immune response by negative strand RNA viruses, mainly Arenaviruses and Influenza viruses.

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Biography

Professional Background

- 1994: MSc Degree in Biology awarded by the University of Navarra (Spain).
- 1996-2000: PhD Thesis. Estudio de las interacciones entre las proteínas implicadas en los procesos de replicación y transcripción del Virus Respiratorio Sincitial. Mentor: José Antonio Melero Fondevila. Research Center: Centro Nacional de Biología Fundamental, Instituto de Salud Carlos III. Madrid, Spain.
- 2000-2007: Post-doctoral fellow. Mentor: Dr. Adolfo García-Sastre. Research Center: Mount Sinai School of Medicine. Microbiology Department. 1 Gustave L. Levy Place, New York, NY, 10029.
- 2007 (January)-2008 (July): Research Assistant Professor. Research Center: Mount Sinai School of Medicine. Microbiology Department. 1 Gustave L. Levy Place, New York, NY, 10029.
- 2008 (August)-present: Assistant Professor. Research Center: University of Rochester School of Medicine and Dentistry. Department of Microbiology and Immunology. 601 Elmwood Avenue, Box 672, Rochester, NY, 14642.
- 2012 (January)-present: External Professor Universidad de Merida en Yucatan, Mexico.

Research

My research interest for the last decade has been focused on the molecular biology, immunology, and pathogenesis of negative-strand (Influenza viruses, Respiratory Syncytial Virus, Human Metapneumovirus, arenavirus, Thogoto virus, Ebola virus, Crimean Congo Hemorrhagic Fever virus) and positive-strand (Dengue virus, SARS coronavirus, Mouse Hepatitis virus) RNA, and DNA viruses. I have extensive knowledge in reverse genetics techniques for rescuing RNA and DNA viruses, pioneered the development of techniques and screening assays to identify viral-encoded interferon antagonist proteins, and established new molecular biology techniques to study highly pathogenic viruses without the requirement of special biosafety conditions. My major contributions to the virology field include the development of new experimental systems to answer difficult questions in the mechanisms of virus-host interactions, including: 1) Reverse genetics tools to genetically manipulate viruses, that I have used to examine virus-host interactions and development of vaccines; 2) Plasmid, virus and cellular based assays for the identification of virus-encoded IFN-antagonist proteins that I have used to uncover molecular mechanisms involved in viral pathogenesis, including the first description of an IFN antagonist protein in the arenavirus family and the multiple anti-IFN actions of influenza virus NS1; and 3) Single-cycle infectious influenza and arenaviruses to study highly pathogenic viruses, without the requirement of special biosafety conditions.
Since my recent appointment in the Department of Microbiology and Immunology at University of Rochester, one of the 5 NIAID Centers of Excellence for Influenza Research and Surveillance, my research has focused on the interactions of influenza and arenavirus proteins with the host cell. My experience in molecular biology, virus reverse genetics techniques, and virus-based bioassays to study the interferon response gives me the unique opportunity to carry out innovative and original research projects, the major objective of which is to shed light and understand the molecular determinants of patogenesis of influenza and arenaviruses and how these viruses interact with their hosts.

Credentials

Faculty Appointments

Awards

2011
- ASM International Professorship for Latin America and the Caribbean
Sponsor: American Society for Microbiology

2010
- Special Recognition from the NIAID, Division of Microbiology and Infectious Disease for H1N1 influenza work
Sponsor: NIAID

2008
- American Society for Virology travel award to attend the XVIth International Congress of Virology in Istanbul, Turkey.
Sponsor: American Society for Virology

2007
- International Society for Interferon and Cytokine Research Young Investigator Award for the 2007 ISICR meeting in Oxford
Sponsor: ISICR

2006
- International Society for Interferon and Cytokine Research Travel Award for the 2006 ISICR meeting in Vienna, Austria
Sponsor: ISICR

2005
- International Society for Interferon and Cytokine Research Travel Award for the 2005 ISICR meeting in Shangai, China.
Sponsor: ISICR

1996 - 2000
- Graduate Fellowship: Evaluation of interactions among human respiratory syncytial virus (HRSV) ribonucleoprotein components.
Sponsor: Ministerio de Sanidad (National Institute of Health)

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Publications

Journal Articles

9/1/2017
Nogales A, Rodriguez L, DeDiego ML, Topham DJ, Martínez-Sobrido L. "Interplay of PA-X and NS1 Proteins in Replication and Pathogenesis of a Temperature-Sensitive 2009 Pandemic H1N1 Influenza A Virus." Journal of virology.. 2017 Sep 1; 91(17)Epub 2017 Aug 10.

9/1/2017
Clark AM, Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML. "Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses." Journal of virology.. 2017 Sep 1; 91(17)Epub 2017 Aug 10.

8/10/2017
Domm W, Yee M, Misra RS, Gelein R, Nogales A, Martinez Sobrido L, O'Reilly MA. "Oxygen-dependent changes in lung development do not affect epithelial infection with influenza A virus." American journal of physiology. Lung cellular and molecular physiology.. 2017 Aug 10; :ajplung.00203.2017. Epub 2017 Aug 10.

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