Stephen R. Hammes, M.D., Ph.D.

Stephen R. Hammes, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 693
Rochester, NY 14642

Administrative: (585) 275-2901
Fax: (585) 273-1288

Journal Articles

Showing all 71 journal articles available.

2016 Dec
Miedlich SU, Karamooz N, Hammes SR. "Aromatase deficiency in a male patient - Case report and review of the literature." Bone. 2016 Dec; 93:181-186. Epub 2016 Sep 29.
2016 Oct
Hammes SR. "Editorial: Final Musings on the Impact of Molecular Endocrinology." Molecular endocrinology. 2016 Oct; 30(10):1027-1028.
2016 Sep
Prizant H, Hammes SR. "Minireview: Lymphangioleiomyomatosis (LAM): The "Other" Steroid-Sensitive Cancer." Endocrinology. 2016 Sep; 157(9):3374-83. Epub 2016 Jul 13.
2016 Apr
Prizant H, Taya M, Lerman I, Light A, Sen A, Mitra S, Foster T, Hammes SR. "Estrogen maintains myometrial tumors in a lymphangioleiomyomatosis model." Endocrine-related cancer. 2016 Apr; 23(4):265-80. Epub 2016 Feb 15.
2016 Mar
"Leptin-Induced CART (Cocaine- and Amphetamine-Regulated Transcript) Is a Novel Intraovarian Mediator of Obesity-Related Infertility in Females." Endocrinology. 2016 Mar; 157(3):1248-57. Epub 2016 Jan 05.
2015 Sep
Light A, Hammes SR. "LH-Induced Steroidogenesis in the Mouse Ovary, but Not Testis, Requires Matrix Metalloproteinase 2- and 9-Mediated Cleavage of Upregulated EGF Receptor Ligands." Biology of reproduction. 2015 Sep; 93(3):65. Epub 2015 Jul 22.
2015 Aug
Hammes SR. "Editorial: Selling Science in the 21st Century (Or, Trying to Teach an Old Dog New Tricks)." Molecular endocrinology. 2015 Aug; 29(8):1093-4.
2015 May
Hammes SR. "Editorial: selling your science: where preparation meets genius." Molecular endocrinology. 2015 May; 29(5):643-4.
2015 Feb
Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman ME, Hammes SR, Lange CA, Santen RJ. "Statement of principle." Hormones & cancer. 2015 Feb; 6(1):1.
2015 Jan
Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman M, Hammes SR, Lange CA, Santen RJ. "Statement of Principle." Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2015 Jan; 21(1):87.
2014 Dec 2
Singhai A, Wakefield DL, Bryant KL, Hammes SR, Holowka D, Baird B. "Spatially defined EGF receptor activation reveals an F-actin-dependent phospho-Erk signaling complex." Biophysical journal. 2014 Dec 2; 107(11):2639-51. Epub 2014 Dec 02.
2014 Dec
Ton QV, Hammes SR. "Recent insights on circulating catecholamines in hypertension." Current hypertension reports. 2014 Dec; 16(12):498.
2014 Dec
Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman M, Hammes SR, Lange CA, Santen RJ. "Statement of principle." Endocrine reviews. 2014 Dec; 35(6):850. Epub 2014 Nov 03.
2014 Nov
Hammes SR. "Editorial: Debates in graduate medical education: who will care for us when we get older?" Molecular endocrinology. 2014 Nov; 28(11):1753-5.
2014 Aug
Hammes SR, Lange CA. "Lost in translation: can we afford to miss the trees for the forest?" Hormones & cancer. 2014 Aug; 5(4):203-6.
2014 Aug
Hammes SR. "Editorial: Sex matters in preclinical research." Molecular endocrinology. 2014 Aug; 28(8):1209-10. Epub 2014 Jul 28.
2014 Jun 17
Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC. "Simultaneous adrenal and cardiac g-protein-coupled receptor-g?? inhibition halts heart failure progression." Journal of the American College of Cardiology. 2014 Jun 17; 63(23):2549-57. Epub 2014 Apr 02.
2014 Feb 25
Sen A, Prizant H, Light A, Biswas A, Hayes E, Lee HJ, Barad D, Gleicher N, Hammes SR. "Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression." Proceedings of the National Academy of Sciences of the United States of America. 2014 Feb 25; 111(8):3008-13. Epub 2014 Feb 10.
2014 Jan
Hammes SR. "Editorial: welcome to molecular endocrinology: pitfalls and promises for the future." Molecular endocrinology. 2014 Jan; 28(1):1-2.
Hammes SR, Miedlich SU, Sen A. "Paxillin and steroid signaling: from frog to human." Methods in molecular biology. 2014 1204:95-108.
2013 Sep
Prizant H, Sen A, Light A, Cho SN, Demayo FJ, Lydon JP, Hammes SR. "Uterine-specific loss of Tsc2 leads to myometrial tumors in both the uterus and lungs." Molecular endocrinology. 2013 Sep; 27(9):1403-14. Epub 2013 Jul 02.
2013 Jun
Light A, Hammes SR. "Membrane receptor cross talk in steroidogenesis: recent insights and clinical implications." Steroids. 2013 Jun; 78(6):633-8. Epub 2013 Feb 01.
Steinman RA, De Castro IO, Shrayyef M, Chengazi V, Giampoli E, Van Der Sloot P, Calvi LM, Wittlin SD, Hammes SR, Hou R. "Two cases of malignant struma ovarii with metastasis to pelvic bone." Gynecologic and obstetric investigation. 2013 75(2):139-44. Epub 2013 Feb 06.
2012 Jul
Sen A, De Castro I, Defranco DB, Deng FM, Melamed J, Kapur P, Raj GV, Rossi R, Hammes SR. "Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation." The Journal of clinical investigation. 2012 Jul; 122(7):2469-81. Epub 2012 Jun 11.
2012 Jun
Grubisha MJ, Cifuentes ME, Hammes SR, Defranco DB. "A local paracrine and endocrine network involving TGF?, Cox-2, ROS, and estrogen receptor ? influences reactive stromal cell regulation of prostate cancer cell motility." Molecular endocrinology. 2012 Jun; 26(6):940-54. Epub 2012 May 16.
2012 Apr
Yang L, Ravindranathan P, Ramanan M, Kapur P, Hammes SR, Hsieh JT, Raj GV. "Central role for PELP1 in nonandrogenic activation of the androgen receptor in prostate cancer." Molecular endocrinology. 2012 Apr; 26(4):550-61. Epub 2012 Mar 08.
2011 Dec
Hammes SR, Levin ER. "Minireview: Recent advances in extranuclear steroid receptor actions." Endocrinology. 2011 Dec; 152(12):4489-95. Epub 2011 Oct 25.
2011 Aug
Sen A, Prizant H, Hammes SR. "Understanding extranuclear (nongenomic) androgen signaling: what a frog oocyte can tell us about human biology." Steroids. 2011 Aug; 76(9):822-8. Epub 2011 Feb 25.
2011 Jun
Carbajal L, Biswas A, Niswander LM, Prizant H, Hammes SR. "GPCR/EGFR cross talk is conserved in gonadal and adrenal steroidogenesis but is uniquely regulated by matrix metalloproteinases 2 and 9 in the ovary." Molecular endocrinology. 2011 Jun; 25(6):1055-65. Epub 2011 Mar 31.
2011 Feb
Strauss TJ, Castrillon DH, Hammes SR. "GATA-like protein-1 (GLP-1) is required for normal germ cell development during embryonic oogenesis." Reproduction : the official journal of the Society for the Study of Fertility. 2011 Feb; 141(2):173-81. Epub 2010 Dec 01.
2010 Sep 10
Sen A, O'Malley K, Wang Z, Raj GV, Defranco DB, Hammes SR. "Paxillin regulates androgen- and epidermal growth factor-induced MAPK signaling and cell proliferation in prostate cancer cells." The Journal of biological chemistry. 2010 Sep 10; 285(37):28787-95. Epub 2010 Jul 13.
2010 Jul
Sen A, Hammes SR. "Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function." Molecular endocrinology. 2010 Jul; 24(7):1393-403. Epub 2010 May 25.
Sen A, Hammes SR. "Just when you thought it was safe to go into the membrane: the growing complexities of extra-nuclear progesterone signaling." Breast cancer research : BCR. 2010 12(3):109. Epub 2010 Jun 16.
2009 Aug
Grasfeder LL, Gaillard S, Hammes SR, Ilkayeva O, Newgard CB, Hochberg RB, Dwyer MA, Chang CY, McDonnell DP. "Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha." Molecular endocrinology. 2009 Aug; 23(8):1171-82. Epub 2009 Apr 23.
2009 Jul
Deng J, Carbajal L, Evaul K, Rasar M, Jamnongjit M, Hammes SR. "Nongenomic steroid-triggered oocyte maturation: of mice and frogs." Steroids. 2009 Jul; 74(7):595-601. Epub 2008 Nov 24.
2009 Jul
Carbajal L, Deng J, Dressing GE, Hagan CR, Lange CA, Hammes SR. "Meeting review: Extra-nuclear steroid receptors-Integration with multiple signaling pathways." Steroids. 2009 Jul; 74(7):551-4. Epub 2008 Nov 27.
2009 Mar
Ghayee HK, Havekes B, Corssmit EP, Eisenhofer G, Hammes SR, Ahmad Z, Tessnow A, Lazúrová I, Adams KT, Fojo AT, Pacak K, Auchus RJ. "Mediastinal paragangliomas: association with mutations in the succinate dehydrogenase genes and aggressive behavior." Endocrine-related cancer. 2009 Mar; 16(1):291-9. Epub 2008 Dec 15.
2008 Oct 10
Evaul K, Hammes SR. "Cross-talk between G protein-coupled and epidermal growth factor receptors regulates gonadotropin-mediated steroidogenesis in Leydig cells." The Journal of biological chemistry. 2008 Oct 10; 283(41):27525-33. Epub 2008 Aug 13.
2008 Aug
Deng J, Lang S, Wylie C, Hammes SR. "The Xenopus laevis isoform of G protein-coupled receptor 3 (GPR3) is a constitutively active cell surface receptor that participates in maintaining meiotic arrest in X. laevis oocytes." Molecular endocrinology. 2008 Aug; 22(8):1853-65. Epub 2008 May 29.
2007 Dec
Hammes SR, Levin ER. "Extranuclear steroid receptors: nature and actions." Endocrine reviews. 2007 Dec; 28(7):726-41. Epub 2007 Oct 04.
2007 Feb
Gill A, Hammes SR. "G beta gamma signaling reduces intracellular cAMP to promote meiotic progression in mouse oocytes." Steroids. 2007 Feb; 72(2):117-23. Epub 2006 Dec 18.
2007 Jan 1
Li S, Lu MM, Zhou D, Hammes SR, Morrisey EE. "GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell development." Developmental biology. 2007 Jan 1; 301(1):106-16. Epub 2006 Aug 11.
2007 Jan
Evaul K, Jamnongjit M, Bhagavath B, Hammes SR. "Testosterone and progesterone rapidly attenuate plasma membrane Gbetagamma-mediated signaling in Xenopus laevis oocytes by signaling through classical steroid receptors." Molecular endocrinology. 2007 Jan; 21(1):186-96. Epub 2006 Oct 04.
Lange CA, Gioeli D, Hammes SR, Marker PC. "Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer." Annual review of physiology. 2007 69:171-99.
2006 Dec 22
Rasar M, DeFranco DB, Hammes SR. "Paxillin regulates steroid-triggered meiotic resumption in oocytes by enhancing an all-or-none positive feedback kinase loop." The Journal of biological chemistry. 2006 Dec 22; 281(51):39455-64. Epub 2006 Oct 25.
2006 Nov
VanLandingham JW, Cutler SM, Virmani S, Hoffman SW, Covey DF, Krishnan K, Hammes SR, Jamnongjit M, Stein DG. "The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury." Neuropharmacology. 2006 Nov; 51(6):1078-85. Epub 2006 Aug 22.
2006 Jun
Jamnongjit M, Hammes SR. "Ovarian steroids: the good, the bad, and the signals that raise them." Cell cycle. 2006 Jun; 5(11):1178-83. Epub 2006 Jun 01.
Rasar MA, Hammes SR. "The physiology of the Xenopus laevis ovary." Methods in molecular biology. 2006 322:17-30.
2005 Nov 8
Jamnongjit M, Gill A, Hammes SR. "Epidermal growth factor receptor signaling is required for normal ovarian steroidogenesis and oocyte maturation." Proceedings of the National Academy of Sciences of the United States of America. 2005 Nov 8; 102(45):16257-62. Epub 2005 Oct 31.
2005 Aug
Haas D, White SN, Lutz LB, Rasar M, Hammes SR. "The modulator of nongenomic actions of the estrogen receptor (MNAR) regulates transcription-independent androgen receptor-mediated signaling: evidence that MNAR participates in G protein-regulated meiosis in Xenopus laevis oocytes." Molecular endocrinology. 2005 Aug; 19(8):2035-46. Epub 2005 Apr 14.
2005 Aug
Jamnongjit M, Hammes SR. "Oocyte maturation: the coming of age of a germ cell." Seminars in reproductive medicine. 2005 Aug; 23(3):234-41.
2005 Mar 18
Yang WH, Hammes SR. "Xenopus laevis CYP17 regulates androgen biosynthesis independent of the cofactor cytochrome b5." The Journal of biological chemistry. 2005 Mar 18; 280(11):10196-201. Epub 2005 Jan 07.
White SN, Jamnongjit M, Gill A, Lutz LB, Hammes SR. "Specific modulation of nongenomic androgen signaling in the ovary." Steroids. 2005 70(5-7):352-60. Epub 2005 Mar 16.
2004 Apr
Hammes SR. "Steroids and oocyte maturation--a new look at an old story." Molecular endocrinology. 2004 Apr; 18(4):769-75. Epub 2003 Nov 20.
2004 Jan
Gill A, Jamnongjit M, Hammes SR. "Androgens promote maturation and signaling in mouse oocytes independent of transcription: a release of inhibition model for mammalian oocyte meiosis." Molecular endocrinology. 2004 Jan; 18(1):97-104. Epub 2003 Oct 23.
2003 Nov 14
Han S, Xie W, Hammes SR, DeJong J. "Expression of the germ cell-specific transcription factor ALF in Xenopus oocytes compensates for translational inactivation of the somatic factor TFIIA." The Journal of biological chemistry. 2003 Nov 14; 278(46):45586-93. Epub 2003 Aug 14.
2003 Jun
Lutz LB, Jamnongjit M, Yang WH, Jahani D, Gill A, Hammes SR. "Selective modulation of genomic and nongenomic androgen responses by androgen receptor ligands." Molecular endocrinology. 2003 Jun; 17(6):1106-16. Epub 2003 Mar 13.
2003 Mar 14
Yang WH, Lutz LB, Hammes SR. "Xenopus laevis ovarian CYP17 is a highly potent enzyme expressed exclusively in oocytes. Evidence that oocytes play a critical role in Xenopus ovarian androgen production." The Journal of biological chemistry. 2003 Mar 14; 278(11):9552-9. Epub 2003 Jan 09.
2003 Mar 4
Hammes SR. "The further redefining of steroid-mediated signaling." Proceedings of the National Academy of Sciences of the United States of America. 2003 Mar 4; 100(5):2168-70. Epub 2003 Feb 26.
2002 Jul 29
Thøgersen IB, Hammes SR, Rubenstein DS, Pizzo SV, Valnickova Z, Enghild JJ. "New member of the trefoil factor family of proteins is an alpha-macroglobulin protease inhibitor." Biochimica et biophysica acta. 2002 Jul 29; 1598(1-2):131-9.
2001 Nov 20
Lutz LB, Cole LM, Gupta MK, Kwist KW, Auchus RJ, Hammes SR. "Evidence that androgens are the primary steroids produced by Xenopus laevis ovaries and may signal through the classical androgen receptor to promote oocyte maturation." Proceedings of the National Academy of Sciences of the United States of America. 2001 Nov 20; 98(24):13728-33. Epub 2001 Nov 13.
2000 Dec 29
Lutz LB, Kim B, Jahani D, Hammes SR. "G protein beta gamma subunits inhibit nongenomic progesterone-induced signaling and maturation in Xenopus laevis oocytes. Evidence for a release of inhibition mechanism for cell cycle progression." The Journal of biological chemistry. 2000 Dec 29; 275(52):41512-20.
1999 Jul 20
Hammes SR, Shapiro MJ, Coughlin SR. "Shutoff and agonist-triggered internalization of protease-activated receptor 1 can be separated by mutation of putative phosphorylation sites in the cytoplasmic tail." Biochemistry. 1999 Jul 20; 38(29):9308-16.
1999 Feb 23
Hammes SR, Coughlin SR. "Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand." Biochemistry. 1999 Feb 23; 38(8):2486-93.
1998 Nov 10
Trejo J, Hammes SR, Coughlin SR. "Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting." Proceedings of the National Academy of Sciences of the United States of America. 1998 Nov 10; 95(23):13698-702.
1998 Sep 4
Kahn ML, Hammes SR, Botka C, Coughlin SR. "Gene and locus structure and chromosomal localization of the protease-activated receptor gene family." The Journal of biological chemistry. 1998 Sep 4; 273(36):23290-6.
1996 May
Hsu DK, Hammes SR, Kuwabara I, Greene WC, Liu FT. "Human T lymphotropic virus-I infection of human T lymphocytes induces expression of the beta-galactoside-binding lectin, galectin-3." The American journal of pathology. 1996 May; 148(5):1661-70.
1993 Mar
Hammes SR, Greene WC. "Multiple arginine residues within the basic domain of HTLV-I Rex are required for specific RNA binding and function." Virology. 1993 Mar; 193(1):41-9.
1991 Aug 15
Fung MR, Scearce RM, Hoffman JA, Peffer NJ, Hammes SR, Hosking JB, Schmandt R, Kuziel WA, Haynes BF, Mills GB. "A tyrosine kinase physically associates with the beta-subunit of the human IL-2 receptor." The Journal of immunology : official journal of the American Association of Immunologists. 1991 Aug 15; 147(4):1253-60.
Hammes SR, Dixon EP, Malim MH, Cullen BR, Greene WC. "Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor." Proceedings of the National Academy of Sciences of the United States of America. 1989 86(23):9549-53.
1987 Aug
Estes K, Monfalcone LL, Hammes SR, Holowka D, Baird B. "Membrane-bound IgE receptor complexes fused with rat basophilic leukemia cells mediate degranulation." The Journal of cell biology. 1987 Aug; 105(2):747-53.