Javier Rangel-Moreno, Ph.D.

Javier Rangel-Moreno, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 695
Rochester, NY 14642

Fax: (585) 442-3214
Office: (585) 275-0364

Journal Articles

Showing all 50 journal articles available.

2016 Sep
Rangel-Moreno J, To JY, Owen T, Goldman BI, Smrcka AV, Anolik JH. "Inhibition of G Protein ?? Subunit Signaling Abrogates Nephritis in Lupus-Prone Mice." Arthritis & rheumatology. 2016 Sep; 68(9):2244-56.
2016 Jul
Solleti SK, Srisuma S, Bhattacharya S, Rangel-Moreno J, Bijli KM, Randall TD, Rahman A, Mariani TJ. "Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 Jul; 30(7):2615-26. Epub 2016 Apr 08.
2016 Apr
Meednu N, Zhang H, Owen T, Sun W, Wang V, Cistrone C, Rangel-Moreno J, Xing L, Med B, Anolik JH. "Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis." Arthritis & rheumatology. 2016 Apr; 68(4):805-16.
2015 Oct
Rangel-Moreno J, de la Luz Garcia-Hernandez M, Ramos-Payan R, Biear J, Hernady E, Sangster MY, Randall TD, Johnston CJ, Finkelstein JN, Williams JP. "Long-Lasting Impact of Neonatal Exposure to Total Body Gamma Radiation on Secondary Lymphoid Organ Structure and Function." Radiation research. 2015 Oct; 184(4):352-66. Epub 2015 Sep 23.
2015 Sep 1
Barone F, Nayar S, Campos J, Cloake T, Withers DR, Toellner KM, Zhang Y, Fouser L, Fisher B, Bowman S, Rangel-Moreno J, Garcia-Hernandez ML, Randall TD, Lucchesi D, Bombardieri M, Pitzalis C, Luther SA, Buckley CD. "IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs." Proceedings of the National Academy of Sciences of the United States of America. 2015 Sep 1; 112(35):11024-9. Epub 2015 Aug 18.
2015 Sep
Monin L, Griffiths KL, Slight S, Lin Y, Rangel-Moreno J, Khader SA. "Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge." Mucosal immunology. 2015 Sep; 8(5):1099-109. Epub 2015 Jan 28.
Kaushal D, Foreman TW, Gautam US, Alvarez X, Adekambi T, Rangel-Moreno J, Golden NA, Johnson AM, Phillips BL, Ahsan MH, Russell-Lodrigue KE, Doyle LA, Roy CJ, Didier PJ, Blanchard JL, Rengarajan J, Lackner AA, Khader SA, Mehra S. "Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis." Nature communications. 2015 6:8533. Epub 2015 Oct 13.
Guerrero GG, Rangel-Moreno J, Islas-Trujillo S, Rojas-Espinosa Ó. "Successive Intramuscular Boosting with IFN-Alpha Protects Mycobacterium bovis BCG-Vaccinated Mice against M. lepraemurium Infection." BioMed research international. 2015 2015:414027. Epub 2015 Sep 21.
Monin L, Griffiths KL, Lam WY, Gopal R, Kang DD, Ahmed M, Rajamanickam A, Cruz-Lagunas A, Zúñiga J, Babu S, Kolls JK, Mitreva M, Rosa BA, Ramos-Payan R, Morrison TE, Murray PJ, Rangel-Moreno J, Pearce EJ, Khader SA. "Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis." The Journal of clinical investigation. 2015 125(12):4699-713. Epub 2015 Nov 16.
2014 May
Gopal R, Monin L, Slight S, Uche U, Blanchard E, A Fallert Junecko B, Ramos-Payan R, Stallings CL, Reinhart TA, Kolls JK, Kaushal D, Nagarajan U, Rangel-Moreno J, Khader SA. "Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection." PLoS pathogens. 2014 May; 10(5):e1004099. Epub 2014 May 15.
2014 Apr 1
Wang W, Rangel-Moreno J, Owen T, Barnard J, Nevarez S, Ichikawa HT, Anolik JH. "Long-term B cell depletion in murine lupus eliminates autoantibody-secreting cells and is associated with alterations in the kidney plasma cell niche." The Journal of immunology : official journal of the American Association of Immunologists. 2014 Apr 1; 192(7):3011-20. Epub 2014 Feb 26.
2014 Feb 1
Palanichamy A, Bauer JW, Yalavarthi S, Meednu N, Barnard J, Owen T, Cistrone C, Bird A, Rabinovich A, Nevarez S, Knight JS, Dedrick R, Rosenberg A, Wei C, Rangel-Moreno J, Liesveld J, Sanz I, Baechler E, Kaplan MJ, Anolik JH. "Neutrophil-mediated IFN activation in the bone marrow alters B cell development in human and murine systemic lupus erythematosus." The Journal of immunology : official journal of the American Association of Immunologists. 2014 Feb 1; 192(3):906-18. Epub 2013 Dec 30.
2014 Jan
Gopal R, Rangel-Moreno J, Fallert Junecko BA, Mallon DJ, Chen K, Pociask DA, Connell TD, Reinhart TA, Alcorn JF, Ross TM, Kolls JK, Khader SA. "Mucosal pre-exposure to Th17-inducing adjuvants exacerbates pathology after influenza infection." The American journal of pathology. 2014 Jan; 184(1):55-63. Epub 2013 Nov 01.
2013 Nov 1
Gopal R, Monin L, Torres D, Slight S, Mehra S, McKenna K, Fallert Junecko BA, Reinhart TA, Kolls J, Báez-Saldaña R, Cruz-Lagunas A, Rodríguez-Reyna TS, Kumar NP, Tessier P, Roth J, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Cumming B, Kasprowicz VO, Steyn AJ, Babu S, Kaushal D, Zúñiga J, Vogl T, Rangel-Moreno J, Khader SA. "S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis." American journal of respiratory and critical care medicine. 2013 Nov 1; 188(9):1137-46.
2013 Nov 1
Perez-Nazario N, Rangel-Moreno J, O'Reilly MA, Pasparakis M, Gigliotti F, Wright TW. "Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis." The Journal of immunology : official journal of the American Association of Immunologists. 2013 Nov 1; 191(9):4720-30. Epub 2013 Sep 27.
2013 Nov
Slight SR, Monin L, Gopal R, Avery L, Davis M, Cleveland H, Oury TD, Rangel-Moreno J, Khader SA. "IL-10 restrains IL-17 to limit lung pathology characteristics following pulmonary infection with Francisella tularensis live vaccine strain." The American journal of pathology. 2013 Nov; 183(5):1397-404. Epub 2013 Sep 03.
2013 Sep
Gopal R, Rangel-Moreno J, Slight S, Lin Y, Nawar HF, Fallert Junecko BA, Reinhart TA, Kolls J, Randall TD, Connell TD, Khader SA. "Interleukin-17-dependent CXCL13 mediates mucosal vaccine-induced immunity against tuberculosis." Mucosal immunology. 2013 Sep; 6(5):972-84. Epub 2013 Jan 09.
2013 Aug 1
Botelho FM, Rangel-Moreno J, Fritz D, Randall TD, Xing Z, Richards CD. "Pulmonary expression of oncostatin M (OSM) promotes inducible BALT formation independently of IL-6, despite a role for IL-6 in OSM-driven pulmonary inflammation." The Journal of immunology : official journal of the American Association of Immunologists. 2013 Aug 1; 191(3):1453-64. Epub 2013 Jun 24.
2013 Apr
Johnston CJ, Manning CM, Rangel-Moreno J, Randall TD, Hernady E, Finkelstein JN, Williams JP. "Neonatal irradiation sensitizes mice to delayed pulmonary challenge." Radiation research. 2013 Apr; 179(4):475-84. Epub 2012 Mar 15.
2013 Feb
Slight SR, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko BA, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart TA, Randall TD, Khader SA. "CXCR5? T helper cells mediate protective immunity against tuberculosis." The Journal of clinical investigation. 2013 Feb; 123(2):712-26. Epub 2013 Jan 02.
"Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse." PloS one. 2013 8(4):e61681. Epub 2013 Apr 16.
Guglani L, Gopal R, Rangel-Moreno J, Junecko BF, Lin Y, Berger T, Mak TW, Alcorn JF, Randall TD, Reinhart TA, Chan YR, Khader SA. "Lipocalin 2 regulates inflammation during pulmonary mycobacterial infections." PloS one. 2012 7(11):e50052. Epub 2012 Nov 20.
2011 Nov 15
Khader SA, Guglani L, Rangel-Moreno J, Gopal R, Fallert Junecko BA, Fountain JJ, Martino C, Pearl JE, Tighe M, Lin YY, Slight S, Kolls JK, Reinhart TA, Randall TD, Cooper AM. "IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung." The Journal of immunology : official journal of the American Association of Immunologists. 2011 Nov 15; 187(10):5402-7. Epub 2011 Oct 14.
2011 Jul
Rangel-Moreno J, Carragher DM, de la Luz Garcia-Hernandez M, Hwang JY, Kusser K, Hartson L, Kolls JK, Khader SA, Randall TD. "The development of inducible bronchus-associated lymphoid tissue depends on IL-17." Nature immunology. 2011 Jul; 12(7):639-46. Epub 2011 Jun 12.
Rangel-Moreno, J; Carragher, DM; de la Luz Garcia-Hernandez, M; Hwang, JY; Kusser, K; Hartson, L; Kolls, JK; Khader, SA and Randall, TD. "Induction of BALT in the absence of IL17". Nat Immunol. 2011; 13(1): 2.
Kang DD, Lin Y, Moreno JR, Randall TD, Khader SA. "Profiling early lung immune responses in the mouse model of tuberculosis." PloS one. 2011 6(1):e16161. Epub 2011 Jan 13.
2010 Aug 2
Cruz A, Fraga AG, Fountain JJ, Rangel-Moreno J, Torrado E, Saraiva M, Pereira DR, Randall TD, Pedrosa J, Cooper AM, Castro AG. "Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis." The Journal of experimental medicine. 2010 Aug 2; 207(8):1609-16. Epub 2010 Jul 12.
2010 Aug 2
Zhang S, Rozell M, Verma RK, Albu DI, Califano D, VanValkenburgh J, Merchant A, Rangel-Moreno J, Randall TD, Jenkins NA, Copeland NG, Liu P, Avram D. "Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b." The Journal of experimental medicine. 2010 Aug 2; 207(8):1687-99. Epub 2010 Jul 26.
Chiavolini D, Rangel-Moreno J, Berg G, Christian K, Oliveira-Nascimento L, Weir S, Alroy J, Randall TD, Wetzler LM. "Bronchus-associated lymphoid tissue (BALT) and survival in a vaccine mouse model of tularemia." PloS one. 2010 5(6):e11156. Epub 2010 Jun 16.
2009 Nov 20
Lin Y, Ritchea S, Logar A, Slight S, Messmer M, Rangel-Moreno J, Guglani L, Alcorn JF, Strawbridge H, Park SM, Onishi R, Nyugen N, Walter MJ, Pociask D, Randall TD, Gaffen SL, Iwakura Y, Kolls JK, Khader SA. "Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis." Immunity. 2009 Nov 20; 31(5):799-810. Epub 2009 Oct 22.
2009 May
Rangel-Moreno J, Moyron-Quiroz JE, Carragher DM, Kusser K, Hartson L, Moquin A, Randall TD. "Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigens." Immunity. 2009 May; 30(5):731-43. Epub 2009 May 07.
Khader SA, Rangel-Moreno J, Fountain JJ, Martino CA, Reiley WW, Pearl JE, Winslow GM, Woodland DL, Randall TD, Cooper AM. "In a murine tuberculosis model, the absence of homeostatic chemokines delays granuloma formation and protective immunity." The Journal of immunology : official journal of the American Association of Immunologists. 2009 183(12):8004-14.
2008 Feb
Carragher DM, Rangel-Moreno J, Randall TD. "Ectopic lymphoid tissues and local immunity." Seminars in immunology. 2008 Feb; 20(1):26-42. Epub 2008 Feb 19.
2008 Jan 1
Rangel-Moreno J, Carragher DM, Misra RS, Kusser K, Hartson L, Moquin A, Lund FE, Randall TD. "B cells promote resistance to heterosubtypic strains of influenza via multiple mechanisms." The Journal of immunology : official journal of the American Association of Immunologists. 2008 Jan 1; 180(1):454-63.
Randall TD, Carragher DM, Rangel-Moreno J. "Development of secondary lymphoid organs." Annual review of immunology. 2008 26:627-50.
2007 Jun 19
Rangel-Moreno J, Moyron-Quiroz JE, Hartson L, Kusser K, Randall TD. "Pulmonary expression of CXC chemokine ligand 13, CC chemokine ligand 19, and CC chemokine ligand 21 is essential for local immunity to influenza." Proceedings of the National Academy of Sciences of the United States of America. 2007 Jun 19; 104(25):10577-82. Epub 2007 Jun 11.
2007 Apr
Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, Shen F, Eaton SM, Gaffen SL, Swain SL, Locksley RM, Haynes L, Randall TD, Cooper AM. "IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge." Nature immunology. 2007 Apr; 8(4):369-77. Epub 2007 Mar 11.
Moyron-Quiroz J, Rangel-Moreno J, Carragher DM, Randall TD. "The function of local lymphoid tissues in pulmonary immune responses." Advances in experimental medicine and biology. 2007 590:55-68.
Rangel-Moreno J, Carragher D, Randall TD. "Role of lymphotoxin and homeostatic chemokines in the development and function of local lymphoid tissues in the respiratory tract." Inmunología (Barcelona, Spain : 1987). 2007 26(1):13-28.
2006 Oct
Moyron-Quiroz JE, Rangel-Moreno J, Hartson L, Kusser K, Tighe MP, Klonowski KD, Lefrançois L, Cauley LS, Harmsen AG, Lund FE, Randall TD. "Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organs." Immunity. 2006 Oct; 25(4):643-54.
Rangel-Moreno J, Hartson L, Navarro C, Gaxiola M, Selman M, Randall TD. "Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis." The Journal of clinical investigation. 2006 116(12):3183-94.
2005 Nov 1
Lee BO, Rangel-Moreno J, Moyron-Quiroz JE, Hartson L, Makris M, Sprague F, Lund FE, Randall TD. "CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection." The Journal of immunology : official journal of the American Association of Immunologists. 2005 Nov 1; 175(9):5827-38.
2005 Oct 15
Rangel-Moreno J, Moyron-Quiroz J, Kusser K, Hartson L, Nakano H, Randall TD. "Role of CXC chemokine ligand 13, CC chemokine ligand (CCL) 19, and CCL21 in the organization and function of nasal-associated lymphoid tissue." The Journal of immunology : official journal of the American Association of Immunologists. 2005 Oct 15; 175(8):4904-13.
Rangel-Moreno J; Moyron-Quiroz, JE; and Randall, TD. "The complex role of lymphotoxin in immunity". Mod. Aspects Immunobiol. 2005; 15: 41-46.
2004 Sep
Moyron-Quiroz JE, Rangel-Moreno J, Kusser K, Hartson L, Sprague F, Goodrich S, Woodland DL, Lund FE, Randall TD. "Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity." Nature medicine. 2004 Sep; 10(9):927-34. Epub 2004 Aug 15.
2004 May
Fabre RA, Pérez TM, Aguilar LD, Rangel MJ, Estrada-Garcìa I, Hernández-Pando R, Estrada Parra S. "Transfer factors as immunotherapy and supplement of chemotherapy in experimental pulmonary tuberculosis." Clinical and experimental immunology. 2004 May; 136(2):215-23.
Lee BO, Moyron-Quiroz J, Rangel-Moreno J, Kusser KL, Hartson L, Sprague F, Lund FE, Randall TD. "CD40, but not CD154, expression on B cells is necessary for optimal primary B cell responses." The Journal of immunology : official journal of the American Association of Immunologists. 2003 171(11):5707-17.
2002 Jun
Rangel Moreno J, Estrada García I, De La Luz García Hernández M, Aguilar Leon D, Marquez R, Hernández Pando R. "The role of prostaglandin E2 in the immunopathogenesis of experimental pulmonary tuberculosis." Immunology. 2002 Jun; 106(2):257-66.
2000 Jul
Hernandez-Pando R, Pavon L, Orozco EH, Rangel J, Rook GA. "Interactions between hormone-mediated and vaccine-mediated immunotherapy for pulmonary tuberculosis in BALB/c mice." Immunology. 2000 Jul; 100(3):391-8.
Rojas-Espinosa O, Rangel-Moreno J, Amador-Jiménez A, Parra-Maldonado R, Arce-Paredes P, Torres-López J. "Secretion antigens of Mycobacterium tuberculosis: a comparison between a reference strain and seven wild isolates." Archives of medical research. 1999 30(3):171-8.


Rangel-Moreno, J and Randall, TD. "Rheumatoid lung disease.". Encyclopedia of Molecular Mechanisms of Disease. : Springer, 2009. 1857-1858