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Charles J. Lowenstein, M.D.

Contact Information

Phone Numbers

Appointment: (585) 341-7700

Administrative: (585) 275-2756

Office: (585) 275-2756

Fax: (585) 473-1573

Faculty Appointments

Patient Care Setting



Charles J. Lowenstein, M.D. is Chief of Cardiology at the University of Rochester School of Medicine and Dentistry. Dr. Lowenstein works with patients in the outpatient cardiology office treating cardiovascular diseases such as hypertension and hyperlipidemia. He is board certified in internal medicine and cardiovascular disease.

Professional Background

Charles J. Lowenstein, M.D. is Professor of Medicine, Chief of Cardiology, and Director of the Cardiovascular Research Institute at the University of Rochester School of Medicine and Dentistry. Dr. Lowenstein obtained his M.D. at the Harvard Medical School. He completed his medical residency at The Massachusetts General Hospital and his cardiology fellowship at The Johns Hopkins University School of Medicine. He became Chief of Cardiology at the University of Rochester Medical Center in 2009. He has served on the NIH Atherosclerosis and Inflammation Cardiovascular Sciences study section. He is a member of the Sarnoff Cardiovascular Research Foundation, an organization that funds medical student research.


Dr. Lowenstein's research is focused on vascular biology. One team or researchers explores mechanisms of exocytosis, through which endothelial cells release pro-inflammatory and pro-thrombotic mediators. A second group of scientists study how platelets communicate with endothelial cells. A third area of research involves an exploration of the role of microRNA in endothelial cells. A fourth team investigates how nitric oxide affects vascular inflammation.



  • Cardiovascular Disease - American Board of Internal Medicine


BA | Harvard University

MD | Harvard Medical School

| Massachusetts General Hospital
Medical Resident

| Massachusetts General Hospital
Research and Clinical Fellow

| Massachusetts Institute of Technology
Research Fellow

| The Johns Hopkins University School of Medicine
Cardiology Fellow

Post-doctoral Training & Residency

01/01/1991 - 06/30/1993
Fellowship in Cardiology at Johns Hopkins Hospital

07/01/1989 - 12/31/1990
Research in at Massachusetts General Hospital

07/01/1987 - 06/30/1989
Residency in Internal Medicine at Massachusetts General Hospital

07/01/1986 - 06/30/1987
Internship in Internal Medicine at Massachusetts General Hospital

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2007 - 2007
Sponsor: InterUrban Clinical Club
Location: Baltimore, MD

2005 - 2005
Peter Dolphin Award
Sponsor: Pfizer
Location: Paris, France

2003 - 2003
Sir William Osler Young Investigator Award
Sponsor: Interurban Clinical Club
Location: Baltimore, MD

2002 - 2002
Sponsor: American Society for Clinical Investigation

2000 - 2000
Young Investigators Conference on Atherosclerosis Award
Sponsor: Merck, Inc.
Location: New York, NY

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Journal Articles

Metkus TS, Sokoll LJ, Barth AS, Czarny MJ, Hays AG, Lowenstein CJ, Michos ED, Nolley EP, Post WS, Resar JR, Thiemann DR, Trost JC, Hasan RK. "Myocardial Injury in Severe COVID-19 Compared to Non-COVID Acute Respiratory Distress Syndrome." Circulation.. 2020 Nov 13; Epub 2020 Nov 13.

Lowenstein CJ, Solomon SD. "Severe COVID-19 is a Microvascular Disease." Circulation.. 2020 Sep 2; Epub 2020 Sep 02.

Bennett JA, Mastrangelo MA, Ture SK, Smith CO, Loelius SG, Berg RA, Shi X, Burke RM, Spinelli SL, Cameron SJ, Carey TE, Brookes PS, Gerszten RE, Sabater-Lleal M, de Vries PS, Huffman JE, Smith NL, Morrell CN, Lowenstein CJ. "The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function." Nature communications.. 2020 Jul 13; 11(1):3479. Epub 2020 Jul 13.

Books & Chapters

Book Title: The Role of Nitric Oxide in Myocarditis
Author List: Lowenstein, C.J. and Sun, H.
Edited By: Giles, T.D., Given, M., Greenberg, S.S.
Published By: Springer Verlag 2009

Chapter Title: Exocytosis of Endothelial Cells is Regulated by N-ethylmaleimide Sensitive Factor
Book Title: Methods in Molecular Biology
Author List: Yamakuchi, M., Ferlito, M., Morrell, C.N., Matsushita, K., Fletcher, C.A., Cao, W., and Lowenstein, C.J.
Edited By: Andrei Ivanov
Published By: Humana Press 2008 in Totowa, NJ

Chapter Title: Weibel-Palade Bodies: Vesicular Trafficking on the Vascular Highway
Book Title: The Endothelium: A Comprehensive Reference
Author List: Lowenstein, C.J.
Published By: Cambridge University Press 2007




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